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ENZYME entry: EC

Accepted Name
bile acid-CoA:amino acid N-acyltransferase.
Alternative Name(s)
amino acid N-choloyltransferase.
cholyl-CoA:taurine N-acyltransferase.
cholyl-CoA glycine-taurine N-acyltransferase.
glycine N-choloyltransferase.
glycine--taurine N-acyltransferase.
Reaction catalysed
choloyl-CoA + glycine <=> CoA + glycocholate + H(+)
  • Also acts on CoA derivatives of other bile acids.
  • Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly.
  • Can also conjugate fatty acids to glycine and can act as a very-long- chain acyl-CoA thioesterase.
  • Bile-acid--amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol.
  • This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalyzed by EC
PRIAM enzyme-specific profiles2.3.1.65
KEGG Ligand Database for Enzyme Nomenclature2.3.1.65
IUBMB Enzyme Nomenclature2.3.1.65
MEDLINEFind literature relating to
Rhea expert-curated reactions2.3.1.65
Q14032, BAAT_HUMAN;  Q91X34, BAAT_MOUSE;  Q63276, BAAT_RAT;  

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