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ENZYME

ENZYME entry: EC 2.3.1.65

Accepted Name
bile acid-CoA:amino acid N-acyltransferase
Alternative Name(s)
amino acid N-choloyltransferase
BACAT
BAT
cholyl-CoA:taurine N-acyltransferase
cholyl-CoA glycine-taurine N-acyltransferase
glycine N-choloyltransferase
glycine--taurine N-acyltransferase
Reaction catalysed
choloyl-CoA + glycine = CoA + glycocholate + H(+)
Comment(s)
  • Also acts on CoA derivatives of other bile acids.
  • Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly.
  • Can also conjugate fatty acids to glycine and can act as a very-long- chain acyl-CoA thioesterase.
  • Bile-acid--amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol.
  • This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalyzed by EC 6.2.1.7.
Cross-references
BRENDA2.3.1.65
EC2PDB2.3.1.65
ExplorEnz2.3.1.65
PRIAM enzyme-specific profiles2.3.1.65
KEGG Ligand Database for Enzyme Nomenclature2.3.1.65
IUBMB Enzyme Nomenclature2.3.1.65
IntEnz2.3.1.65
MEDLINEFind literature relating to 2.3.1.65
MetaCyc2.3.1.65
Rhea expert-curated reactions2.3.1.65
UniProtKB/Swiss-Prot
Q14032, BAAT_HUMANQ91X34, BAAT_MOUSEQ63276, BAAT_RAT

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