A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.3.1.65
| Accepted Name |
|---|
| Bile acid-CoA:amino acid N-acyltransferase.
|
| Alternative Name(s) |
|---|
| Amino acid N-choloyltransferase. |
| BACAT. |
| BAT. |
| Cholyl-CoA glycine-taurine N-acyltransferase. |
| Cholyl-CoA:taurine N-acyltransferase. |
| Glycine N-choloyltransferase. |
| Glycine--taurine N-acyltransferase. |
| Reaction catalysed |
|---|
| Choloyl-CoA + glycine <=> CoA + glycocholate |
| Comment(s) |
|---|
- Also acts on CoA derivatives of other bile acids.
- Taurine and 2-fluoro-beta-alanine can act as substrates, but more
slowly.
- Can also conjugate fatty acids to glycine and can act as a very-long-
chain acyl-CoA thioesterase.
- Bile-acid--amino-acid conjugates serve as detergents in the
gastrointestinal tract, solubilizing long chain fatty acids, mono-
and diglycerides, fat-soluble vitamins and cholesterol.
- This is the second enzyme in a two-step process leading to the
conjugation of bile acids with amino acids; the first step is the
conversion of bile acids into their acyl-CoA thioesters, which is
catalyzed by EC 6.2.1.7.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.65 |
| EC2PDB | 2.3.1.65 |
| ExplorEnz | 2.3.1.65 |
| PRIAM enzyme-specific profiles | 2.3.1.65 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.65 |
| IUBMB Enzyme Nomenclature | 2.3.1.65 |
| IntEnz | 2.3.1.65 |
| MEDLINE | Find literature relating to 2.3.1.65 |
| MetaCyc | 2.3.1.65 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-