ENZYME entry: EC 2.3.1.65
Accepted Name |
Bile acid-CoA:amino acid N-acyltransferase.
|
Alternative Name(s) |
Amino acid N-choloyltransferase. |
BACAT. |
BAT. |
Cholyl-CoA glycine-taurine N-acyltransferase. |
Cholyl-CoA:taurine N-acyltransferase. |
Glycine N-choloyltransferase. |
Glycine--taurine N-acyltransferase. |
Reaction catalysed |
Choloyl-CoA + glycine <=> CoA + glycocholate |
Comment(s) |
- Also acts on CoA derivatives of other bile acids.
- Taurine and 2-fluoro-beta-alanine can act as substrates, but more
slowly.
- Can also conjugate fatty acids to glycine and can act as a very-long-
chain acyl-CoA thioesterase.
- Bile-acid--amino-acid conjugates serve as detergents in the
gastrointestinal tract, solubilizing long chain fatty acids, mono-
and diglycerides, fat-soluble vitamins and cholesterol.
- This is the second enzyme in a two-step process leading to the
conjugation of bile acids with amino acids; the first step is the
conversion of bile acids into their acyl-CoA thioesters, which is
catalyzed by EC 6.2.1.7.
|
Cross-references |
BRENDA | 2.3.1.65 |
EC2PDB | 2.3.1.65 |
ExplorEnz | 2.3.1.65 |
PRIAM enzyme-specific profiles | 2.3.1.65 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.65 |
IUBMB Enzyme Nomenclature | 2.3.1.65 |
IntEnz | 2.3.1.65 |
MEDLINE | Find literature relating to 2.3.1.65 |
MetaCyc | 2.3.1.65 |
Rhea expert-curated reactions | 2.3.1.65 |
UniProtKB/Swiss-Prot |
|
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