Home  |  Contact

ENZYME entry: EC 2.3.1.65

Accepted Name
bile acid-CoA:amino acid N-acyltransferase.
Alternative Name(s)
amino acid N-choloyltransferase.
BACAT.
BAT.
cholyl-CoA:taurine N-acyltransferase.
cholyl-CoA glycine-taurine N-acyltransferase.
glycine N-choloyltransferase.
glycine--taurine N-acyltransferase.
Reaction catalysed
choloyl-CoA + glycine <=> CoA + glycocholate + H(+)
Comment(s)
  • Also acts on CoA derivatives of other bile acids.
  • Taurine and 2-fluoro-beta-alanine can act as substrates, but more slowly.
  • Can also conjugate fatty acids to glycine and can act as a very-long- chain acyl-CoA thioesterase.
  • Bile-acid--amino-acid conjugates serve as detergents in the gastrointestinal tract, solubilizing long chain fatty acids, mono- and diglycerides, fat-soluble vitamins and cholesterol.
  • This is the second enzyme in a two-step process leading to the conjugation of bile acids with amino acids; the first step is the conversion of bile acids into their acyl-CoA thioesters, which is catalyzed by EC 6.2.1.7.
Cross-references
BRENDA2.3.1.65
EC2PDB2.3.1.65
ExplorEnz2.3.1.65
PRIAM enzyme-specific profiles2.3.1.65
KEGG Ligand Database for Enzyme Nomenclature2.3.1.65
IUBMB Enzyme Nomenclature2.3.1.65
IntEnz2.3.1.65
MEDLINEFind literature relating to 2.3.1.65
MetaCyc2.3.1.65
Rhea expert-curated reactions2.3.1.65
UniProtKB/Swiss-Prot
Q14032, BAAT_HUMAN;  Q91X34, BAAT_MOUSE;  Q63276, BAAT_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-