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ENZYME entry: EC 2.3.1.177

Accepted Name
3,5-dihydroxybiphenyl synthase.
Alternative Name(s)
biphenyl synthase.
BIS.
Reaction catalysed
benzoyl-CoA + 3 H(+) + 3 malonyl-CoA <=> biphenyl-3,5-diol + 4 CO2 + 4 CoA
Comment(s)
  • A polyketide synthase that is involved in the production of the phytoalexin aucuparin.
  • 2-hydroxybenzoyl-CoA can also act as substrate but it leads to the derailment product 4-hydroxycoumarin (cf. EC 2.3.1.208).
  • This enzyme uses the same starter substrate as EC 2.3.1.151.
Cross-references
BRENDA2.3.1.177
EC2PDB2.3.1.177
ExplorEnz2.3.1.177
PRIAM enzyme-specific profiles2.3.1.177
KEGG Ligand Database for Enzyme Nomenclature2.3.1.177
IUBMB Enzyme Nomenclature2.3.1.177
IntEnz2.3.1.177
MEDLINEFind literature relating to 2.3.1.177
MetaCyc2.3.1.177
Rhea expert-curated reactions2.3.1.177
UniProtKB/Swiss-Prot
Q27Z07, BIPS1_SORAU

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