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ENZYME

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ENZYME entry: EC 2.3.1.179

Accepted Name
beta-ketoacyl-[acyl-carrier-protein] synthase II
Alternative Name(s)
3-oxoacyl-acyl carrier protein synthase I
beta-ketoacyl-ACP synthase II
KASII
KAS II
Reaction catalysed
(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]
Comment(s)
  • Involved in the dissociated (or type II) fatty acid biosynthesis system that occurs in plants and bacteria.
  • While the substrate specificity of this enzyme is very similar to that of EC 2.3.1.41, it differs in that palmitoleoyl-ACP is not a good substrate of EC 2.3.1.41 but is an excellent substrate of this enzyme.
  • The fatty-acid composition of Escherichia coli changes as a function of growth temperature, with the proportion of unsaturated fatty acids increasing with lower growth temperature.
  • Controls the temperature-dependent regulation of fatty-acid composition, with mutants lacking this acivity being deficient in the elongation of palmitoleate to cis-vaccenate at low temperatures.
Cross-references
BRENDA2.3.1.179
EC2PDB2.3.1.179
ExplorEnz2.3.1.179
PRIAM enzyme-specific profiles2.3.1.179
KEGG Ligand Database for Enzyme Nomenclature2.3.1.179
IUBMB Enzyme Nomenclature2.3.1.179
IntEnz2.3.1.179
MEDLINEFind literature relating to 2.3.1.179
MetaCyc2.3.1.179
Rhea expert-curated reactions2.3.1.179
UniProtKB/Swiss-Prot
O34340, FABF_BACSUQ83E37, FABF_COXBUP0AAI7, FABF_ECO57
P0AAI6, FABF_ECOL6P0AAI5, FABF_ECOLIP56902, FABF_RHIME
P0AAI8, FABF_SHIFLQ5HHA1, FABF_STAACQ99VA6, FABF_STAAM
Q7A6F8, FABF_STAANQ6GIA3, FABF_STAARQ6GAU2, FABF_STAAS
Q5TKS0, FABF_STAAUQ8NXE1, FABF_STAAWP73283, FABF_SYNY3
Q9KQH9, FABF_VIBCHP55338, FABF_VIBHA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-