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ENZYME

ENZYME entry: EC 2.3.1.41

Accepted Name
beta-ketoacyl-[acyl-carrier-protein] synthase I
Alternative Name(s)
3-ketoacyl-acyl carrier protein synthase
3-oxoacyl-[acyl-carrier-protein] synthase
acyl-malonyl(acyl-carrier-protein)-condensing enzyme
acyl-malonyl acyl carrier protein-condensing enzyme
beta-ketoacyl-[acyl carrier protein] synthase
beta-ketoacyl-ACP synthase I
beta-ketoacyl-ACP synthetase
beta-ketoacyl acyl carrier protein synthase
beta-ketoacyl-acyl carrier protein synthetase
beta-ketoacylsynthase
beta-ketoacyl synthetase
condensing enzyme
fatty acid condensing enzyme
KAS I
Reaction catalysed
a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2
Comment(s)
  • Responsible for the chain-elongation step of dissociated (type II) fatty-acid biosynthesis, i.e. the addition of two C atoms to the fatty-acid chain.
  • Escherichia coli mutants that lack this enzyme are deficient in unsaturated fatty acids.
  • Can use fatty acyl thioesters of ACP (C2 to C16) as substrates, as well as fatty acyl thioesters of Co-A (C4 to C16).
  • The substrate specificity is very similar to that of EC 2.3.1.179 with the exception that the latter enzyme is far more active with palmitoleoyl-ACP (C16Delta(9)) as substrate, allowing the organism to regulate its fatty-acid composition with changes in temperature.
Cross-references
BRENDA2.3.1.41
EC2PDB2.3.1.41
ExplorEnz2.3.1.41
KEGG Ligand Database for Enzyme Nomenclature2.3.1.41
IUBMB Enzyme Nomenclature2.3.1.41
MEDLINEFind literature relating to 2.3.1.41
MetaCyc2.3.1.41
Rhea expert-curated reactions2.3.1.41
UniProtKB/Swiss-Prot
Q8TGA2, AFLA_ASPPUS0DL59, APF5_GIBF5Q5AV00, ATNF_EMENI
P39525, CEM1_YEASTP57193, FABB_BUCAIQ8KA28, FABB_BUCAP
Q89AY4, FABB_BUCBPP0A954, FABB_ECOL6P0A953, FABB_ECOLI
P43710, FABB_HAEINQ02K94, FABB_PSEABP43098, FAS2_CANAX
G8BAW7, FAS2_CANPCP78615, FAS2_EMENDQ765N2, FAS2_LACKL
P15368, FAS2_PENPAQ10289, FAS2_SCHPOP19097, FAS2_YEAST
Q71SP7, FAS_BOVINP12276, FAS_CHICKP49327, FAS_HUMAN
P19096, FAS_MOUSEP12785, FAS_RATI1R9A6, GRA9_GIBZE
A7TUG9, HEXA_DOTSEM2YJJ3, HEXA_DOTSNP52410, KASC1_ARATH
P23902, KASC1_HORVUQ9C9P4, KASC2_ARATHQ8L3X9, KASM_ARATH
Q7TXK8, MSL7_MYCBOB2HIL7, MSL7_MYCMMQ2TXF0, ORYA_ASPOR
Q0VCA7, OXSM_BOVINQ9NWU1, OXSM_HUMANQ9D404, OXSM_MOUSE
O94297, OXSM_SCHPOA0A1D5AG16, PIGJ_MONRUQ5B7V0, PKIB_EMENI
Q00681, STCJ_EMENIS5NIA2, TOXH_COCCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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