Accepted Name |
beta-ketoacyl-[acyl-carrier-protein] synthase I.
|
Alternative Name(s) |
3-ketoacyl-acyl carrier protein synthase. |
3-oxoacyl-[acyl-carrier-protein] synthase. |
acyl-malonyl(acyl-carrier-protein)-condensing enzyme. |
acyl-malonyl acyl carrier protein-condensing enzyme. |
beta-ketoacyl-[acyl carrier protein] synthase. |
beta-ketoacyl-ACP synthase I. |
beta-ketoacyl-ACP synthetase. |
beta-ketoacyl acyl carrier protein synthase. |
beta-ketoacyl-acyl carrier protein synthetase. |
beta-ketoacylsynthase. |
beta-ketoacyl synthetase. |
condensing enzyme. |
fatty acid condensing enzyme. |
KAS I. |
Reaction catalysed |
a fatty acyl-[ACP] + H(+) + malonyl-[ACP] <=> a 3-oxoacyl-[ACP] + CO2 + holo-[ACP] |
Comment(s) |
- Responsible for the chain-elongation step of dissociated (type II)
fatty-acid biosynthesis, i.e. the addition of two C atoms to the
fatty-acid chain.
- Escherichia coli mutants that lack this enzyme are deficient in
unsaturated fatty acids.
- Can use fatty acyl thioesters of ACP (C2 to C16) as substrates,
as well as fatty acyl thioesters of Co-A (C4 to C16).
- The substrate specificity is very similar to that of EC 2.3.1.179
with the exception that the latter enzyme is far more active with
palmitoleoyl-ACP (C16Delta(9)) as substrate, allowing the organism to
regulate its fatty-acid composition with changes in temperature.
|
Cross-references |
BRENDA | 2.3.1.41 |
EC2PDB | 2.3.1.41 |
ExplorEnz | 2.3.1.41 |
PRIAM enzyme-specific profiles | 2.3.1.41 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.41 |
IUBMB Enzyme Nomenclature | 2.3.1.41 |
IntEnz | 2.3.1.41 |
MEDLINE | Find literature relating to 2.3.1.41 |
MetaCyc | 2.3.1.41 |
Rhea expert-curated reactions | 2.3.1.41 |
UniProtKB/Swiss-Prot |
Q8TGA2, AFLA_ASPPU; | S0DL59, APF5_GIBF5; | Q5AV00, ATNF_EMENI; |
P39525, CEM1_YEAST; | P57193, FABB_BUCAI; | Q8KA28, FABB_BUCAP; |
Q89AY4, FABB_BUCBP; | P0A954, FABB_ECOL6; | P0A953, FABB_ECOLI; |
P43710, FABB_HAEIN; | Q02K94, FABB_PSEAB; | P43098, FAS2_CANAX; |
G8BAW7, FAS2_CANPC; | P78615, FAS2_EMEND; | Q765N2, FAS2_LACKL; |
P15368, FAS2_PENPA; | Q10289, FAS2_SCHPO; | P19097, FAS2_YEAST; |
Q71SP7, FAS_BOVIN; | P12276, FAS_CHICK; | P49327, FAS_HUMAN; |
P19096, FAS_MOUSE; | P12785, FAS_RAT; | I1R9A6, GRA9_GIBZE; |
A7TUG9, HEXA_DOTSE; | M2YJJ3, HEXA_DOTSN; | P52410, KASC1_ARATH; |
P23902, KASC1_HORVU; | Q9C9P4, KASC2_ARATH; | Q8L3X9, KASM_ARATH; |
Q7TXK8, MSL7_MYCBO; | B2HIL7, MSL7_MYCMM; | Q2TXF0, ORYA_ASPOR; |
Q0VCA7, OXSM_BOVIN; | Q9NWU1, OXSM_HUMAN; | Q9D404, OXSM_MOUSE; |
O94297, OXSM_SCHPO; | Q5B7V0, PKIB_EMENI; | Q00681, STCJ_EMENI; |
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