ENZYME entry: EC 2.3.1.231
| Accepted Name |
|---|
| tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-
methoxycarbonyltransferase.
|
| Alternative Name(s) |
|---|
| tRNA-yW synthesizing enzyme-4. |
| Reaction catalysed |
|---|
| S-adenosyl-L-methionine + 7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) + CO(2) <=> S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) |
| Comment(s) |
|---|
- The enzyme is found only in eukaryotes, where it is involved in the
biosynthesis of wybutosine, a hypermodified tricyclic base found at
position 37 of certain tRNAs.
- The modification is important for translational reading-frame
maintenance.
- In some species that produce hydroxywybutosine the enzyme uses
7-(2-hydroxy-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in
tRNA(Phe) as substrate.
- The enzyme also has the activity of EC 2.1.1.290.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.231 |
| EC2PDB | 2.3.1.231 |
| ExplorEnz | 2.3.1.231 |
| PRIAM enzyme-specific profiles | 2.3.1.231 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.231 |
| IUBMB Enzyme Nomenclature | 2.3.1.231 |
| IntEnz | 2.3.1.231 |
| MEDLINE | Find literature relating to 2.3.1.231 |
| MetaCyc | 2.3.1.231 |
| Rhea expert-curated reactions | 2.3.1.231 |
| UniProtKB/Swiss-Prot |
| Q75AW4, TYW4_ASHGO; | Q4WVD1, TYW4_ASPFU; | Q2U6D4, TYW4_ASPOR; |
| Q5A931, TYW4_CANAL; | Q6FXA5, TYW4_CANGA; | Q5BH52, TYW4_EMENI; |
| Q4IER0, TYW4_GIBZE; | O60294, TYW4_HUMAN; | Q8BYR1, TYW4_MOUSE; |
| Q9P3K9, TYW4_NEUCR; | Q5XIA3, TYW4_RAT; | O60157, TYW4_SCHPO; |
| Q6C3P4, TYW4_YARLI; | Q08282, TYW4_YEAST; |
|
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