ENZYME entry: EC 2.3.1.231

Accepted Name

tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}- methoxycarbonyltransferase

Alternative Name(s)

tRNA-yW synthesizing enzyme-4

Reaction catalysed

7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)

Comment(s)

The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
The modification is important for translational reading-frame maintenance.
In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) as substrate.
The enzyme also has the activity of EC 2.1.1.290.

Cross-references

BRENDA

2.3.1.231

EC2PDB

2.3.1.231

ExplorEnz

2.3.1.231

PRIAM enzyme-specific profiles

2.3.1.231

KEGG Ligand Database for Enzyme Nomenclature

2.3.1.231

IUBMB Enzyme Nomenclature

2.3.1.231

IntEnz

2.3.1.231

MEDLINE

Find literature relating to 2.3.1.231

MetaCyc

2.3.1.231

Rhea expert-curated reactions

2.3.1.231

UniProtKB/Swiss-Prot

Q75AW4, TYW4_ASHGO	Q4WVD1, TYW4_ASPFU	Q2U6D4, TYW4_ASPOR
Q5A931, TYW4_CANAL	Q6FXA5, TYW4_CANGA	Q5BH52, TYW4_EMENI
Q4IER0, TYW4_GIBZE	O60294, TYW4_HUMAN	Q8BYR1, TYW4_MOUSE
Q9P3K9, TYW4_NEUCR	Q5XIA3, TYW4_RAT	O60157, TYW4_SCHPO
Q6C3P4, TYW4_YARLI	Q08282, TYW4_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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