ENZYME entry: EC 2.3.1.231
Accepted Name |
tRNA(Phe) (7-(3-amino-3-(methoxycarbonyl)propyl)wyosine(37)-N)-
methoxycarbonyltransferase.
|
Alternative Name(s) |
tRNA-yW synthesizing enzyme-4. |
Reaction catalysed |
S-adenosyl-L-methionine + 7-((3S)-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in tRNA(Phe) + CO(2) <=> S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe) |
Comment(s) |
- The enzyme is found only in eukaryotes, where it is involved in the
biosynthesis of wybutosine, a hypermodified tricyclic base found at
position 37 of certain tRNAs.
- The modification is important for translational reading-frame
maintenance.
- In some species that produce hydroxywybutosine the enzyme uses
7-(2-hydroxy-3-amino-3-(methoxycarbonyl)propyl)wyosine(37) in
tRNA(Phe) as substrate.
- The enzyme also has the activity of EC 2.1.1.290.
|
Cross-references |
BRENDA | 2.3.1.231 |
EC2PDB | 2.3.1.231 |
ExplorEnz | 2.3.1.231 |
PRIAM enzyme-specific profiles | 2.3.1.231 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.231 |
IUBMB Enzyme Nomenclature | 2.3.1.231 |
IntEnz | 2.3.1.231 |
MEDLINE | Find literature relating to 2.3.1.231 |
MetaCyc | 2.3.1.231 |
UniProtKB/Swiss-Prot |
Q75AW4, TYW4_ASHGO; | Q4WVD1, TYW4_ASPFU; | Q2U6D4, TYW4_ASPOR; |
Q5A931, TYW4_CANAL; | Q6FXA5, TYW4_CANGA; | Q5BH52, TYW4_EMENI; |
Q4IER0, TYW4_GIBZE; | O60294, TYW4_HUMAN; | Q8BYR1, TYW4_MOUSE; |
Q9P3K9, TYW4_NEUCR; | Q5XIA3, TYW4_RAT; | O60157, TYW4_SCHPO; |
Q6C3P4, TYW4_YARLI; | Q08282, TYW4_YEAST; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-