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ENZYME entry: EC 2.3.1.231

Accepted Name
tRNA(Phe) {7-[3-amino-3-(methoxycarbonyl)propyl]wyosine(37)-N}- methoxycarbonyltransferase
Alternative Name(s)
tRNA-yW synthesizing enzyme-4
Reaction catalysed
7-[(3S)-(3-amino-3-methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) + CO2 + S-adenosyl-L-methionine <=> 2 H(+) + S-adenosyl-L-homocysteine + wybutosine(37) in tRNA(Phe)
Comment(s)
  • The enzyme is found only in eukaryotes, where it is involved in the biosynthesis of wybutosine, a hypermodified tricyclic base found at position 37 of certain tRNAs.
  • The modification is important for translational reading-frame maintenance.
  • In some species that produce hydroxywybutosine the enzyme uses 7-[2-hydroxy-3-amino-3-(methoxycarbonyl)propyl]wyosine(37) in tRNA(Phe) as substrate.
  • The enzyme also has the activity of EC 2.1.1.290.
Cross-references
BRENDA2.3.1.231
EC2PDB2.3.1.231
ExplorEnz2.3.1.231
PRIAM enzyme-specific profiles2.3.1.231
KEGG Ligand Database for Enzyme Nomenclature2.3.1.231
IUBMB Enzyme Nomenclature2.3.1.231
IntEnz2.3.1.231
MEDLINEFind literature relating to 2.3.1.231
MetaCyc2.3.1.231
Rhea expert-curated reactions2.3.1.231
UniProtKB/Swiss-Prot
Q4WVD1, TYW4_ASPFUQ2U6D4, TYW4_ASPORQ5A931, TYW4_CANAL
Q6FXA5, TYW4_CANGAQ5BH52, TYW4_EMENIQ75AW4, TYW4_EREGS
Q4IER0, TYW4_GIBZEO60294, TYW4_HUMANQ8BYR1, TYW4_MOUSE
Q9P3K9, TYW4_NEUCRQ5XIA3, TYW4_RATO60157, TYW4_SCHPO
Q6C3P4, TYW4_YARLIQ08282, TYW4_YEAST

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