ENZYME entry: EC 2.3.1.235

Accepted Name
Tetracenomycin F2 synthase.
Reaction catalysed
10 malonyl-CoA <=> tetracenomycin F2 + 10 CoA + 10 CO(2) + 2 H(2)O
Comment(s)
  • A multi-domain polyketide synthase involved in the synthesis of tetracenomycin in the bacterium Streptomyces glaucescens.
  • It involves a ketosynthase complex, an acyl carrier protein, a malonyl CoA:ACP acyltransferase, and a cyclase.
  • A malonyl-CoA molecule is initially bound to the acyl carrier protein and decarboxylated to form an acetyl starter unit.
  • Additional two-carbon units are added from nine more malonyl-CoA molecules.
Cross-references
BRENDA2.3.1.235
EC2PDB2.3.1.235
ExplorEnz2.3.1.235
PRIAM enzyme-specific profiles2.3.1.235
KEGG Ligand Database for Enzyme Nomenclature2.3.1.235
IUBMB Enzyme Nomenclature2.3.1.235
IntEnz2.3.1.235
MEDLINEFind literature relating to 2.3.1.235
MetaCyc2.3.1.235

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-