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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Narbonolide synthase.
Alternative Name(s)
Pikromycin PKS.
Reaction catalysed
Malonyl-CoA + 6 (2S)-methylmalonyl-CoA + 5 NADPH <=> narbonolide + 7 CoA + 7 CO(2) + 5 NADP(+) + 2 H(2)O
  • The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae.
  • The enzyme also produces 10-deoxymethynolide (see EC
  • The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain.
  • Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP).
  • Not all active sites are used in the biosynthesis.
PRIAM enzyme-specific profiles2.3.1.240
KEGG Ligand Database for Enzyme Nomenclature2.3.1.240
IUBMB Enzyme Nomenclature2.3.1.240
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