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ENZYME

ENZYME entry: EC 2.3.1.240

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.240
Accepted Name
narbonolide synthase
Alternative Name(s)
pikromycin PKS
Reaction catalysed
6 (S)-methylmalonyl-CoA + malonyl-CoA + 5 NADPH + 12 H(+) = narbonolide + 7 CO2 + 5 NADP(+) + 7 CoA + 2 H2O
Comment(s)
  • The product, narbonolide, contains a 14-membered ring and is an intermediate in the biosynthesis of narbonomycin and pikromycin in the bacterium Streptomyces venezuelae.
  • The enzyme also produces 10-deoxymethynolide (see EC 2.3.1.239).
  • The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain.
  • Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP).
  • Not all active sites are used in the biosynthesis.
Cross-references
BRENDA2.3.1.240
EC2PDB2.3.1.240
ExplorEnz2.3.1.240
KEGG Ligand Database for Enzyme Nomenclature2.3.1.240
IUBMB Enzyme Nomenclature2.3.1.240
MEDLINEFind literature relating to 2.3.1.240
MetaCyc2.3.1.240
Rhea expert-curated reactions2.3.1.240
UniProtKB/Swiss-Prot
Q9ZGI5, PIKA1_STRVZQ9ZGI4, PIKA2_STRVZQ9ZGI3, PIKA3_STRVZ
Q9ZGI2, PIKA4_STRVZ

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