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ENZYME

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ENZYME entry: EC 2.3.1.239

Accepted Name
10-deoxymethynolide syntase
Alternative Name(s)
(2S)-methylmalonyl-CoA:malonyl-CoA malonyltransferase (10-deoxymethynolide forming)
Reaction catalysed
5 (S)-methylmalonyl-CoA + 11 H(+) + malonyl-CoA + 5 NADPH = 10-deoxymethynolide + 6 CO2 + 6 CoA + 2 H2O + 5 NADP(+)
Comment(s)
  • The product, 10-deoxymethynolide, contains a 12-membered ring and is an intermediate in the biosynthesis of methymycin in the bacterium Streptomyces venezuelae.
  • The enzyme also produces narbonolide (see EC 2.3.1.240).
  • The enzyme has 29 active sites arranged in four polypeptides (pikAI - pikAIV) with a loading domain, six extension modules and a terminal thioesterase domain.
  • Each extension module contains a ketosynthase (KS), keto reductase (KR), an acyltransferase (AT) and an acyl-carrier protein (ACP).
  • Not all active sites are used in the biosynthesis.
Cross-references
BRENDA2.3.1.239
EC2PDB2.3.1.239
ExplorEnz2.3.1.239
PRIAM enzyme-specific profiles2.3.1.239
KEGG Ligand Database for Enzyme Nomenclature2.3.1.239
IUBMB Enzyme Nomenclature2.3.1.239
IntEnz2.3.1.239
MEDLINEFind literature relating to 2.3.1.239
MetaCyc2.3.1.239
Rhea expert-curated reactions2.3.1.239
UniProtKB/Swiss-Prot
Q9ZGI5, PIKA1_STRVZQ9ZGI4, PIKA2_STRVZQ9ZGI3, PIKA3_STRVZ
Q9ZGI2, PIKA4_STRVZ

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