A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.1.244

Accepted Name
2-methylbutanoate polyketide synthase.
Reaction catalysed
2 malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + 2 CO(2) + 2 NADP(+) + S-adenosyl-L-homocysteine + H(2)O
Comment(s)
  • This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus.
  • The overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta enoyl reduction.
Cross-references
BRENDA2.3.1.244
EC2PDB2.3.1.244
ExplorEnz2.3.1.244
PRIAM enzyme-specific profiles2.3.1.244
KEGG Ligand Database for Enzyme Nomenclature2.3.1.244
IUBMB Enzyme Nomenclature2.3.1.244
IntEnz2.3.1.244
MEDLINEFind literature relating to 2.3.1.244
MetaCyc2.3.1.244
UniProtKB/Swiss-Prot
Q9Y7D5, LOVF_ASPTE;  Q8J0F5, MLCB_PENCI;  Q3S2U6, MOKB_MONPI;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-