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ENZYME

ENZYME entry: EC 2.3.1.244

Accepted Name
2-methylbutanoate polyketide synthase
Reaction catalysed
3 H(+) + holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + 2 NADPH + S-adenosyl-L-methionine <=> (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CO2 + 2 CoA + H2O + 2 NADP(+) + S-adenosyl-L-homocysteine
Comment(s)
  • This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus.
  • The overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta enoyl reduction.
Cross-references
BRENDA2.3.1.244
EC2PDB2.3.1.244
ExplorEnz2.3.1.244
PRIAM enzyme-specific profiles2.3.1.244
KEGG Ligand Database for Enzyme Nomenclature2.3.1.244
IUBMB Enzyme Nomenclature2.3.1.244
IntEnz2.3.1.244
MEDLINEFind literature relating to 2.3.1.244
MetaCyc2.3.1.244
Rhea expert-curated reactions2.3.1.244
UniProtKB/Swiss-Prot
Q9Y7D5, LOVF_ASPTEQ0C8L6, LOVF_ASPTNQ8J0F5, MLCB_PENCI
Q3S2U6, MOKB_MONPI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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