ENZYME entry: EC 2.3.1.244

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.244

Accepted Name

2-methylbutanoate polyketide synthase

Reaction catalysed

holo-[2-methylbutanoate polyketide synthase] + 2 malonyl-CoA + S-adenosyl-L-methionine + 2 NADPH + 3 H(+) = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + S-adenosyl-L-homocysteine + 2 CO2 + 2 NADP(+) + 2 CoA + H2O

Comment(s)

This polyketide synthase enzyme forms the (S)-2-methylbutanoate side chain during lovastatin biosynthesis by the filamentous fungus Aspergillus terreus.
The overall reaction comprises a single condensation reaction followed by alpha-methylation, beta-ketoreduction, dehydration, and alpha,beta enoyl reduction.

Cross-references

BRENDA

2.3.1.244

EC2PDB

2.3.1.244

ExplorEnz

2.3.1.244

KEGG Ligand Database for Enzyme Nomenclature

2.3.1.244

IUBMB Enzyme Nomenclature

2.3.1.244

MEDLINE

Find literature relating to 2.3.1.244

MetaCyc

2.3.1.244

Rhea expert-curated reactions

2.3.1.244

UniProtKB/Swiss-Prot

Q9Y7D5, LOVF_ASPTE	Q0C8L6, LOVF_ASPTN	Q8J0F5, MLCB_PENCI
Q3S2U6, MOKB_MONPI

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-