Home  |  Contact

ENZYME entry: EC 2.3.1.253

Accepted Name
Phloroglucinol synthase.
Reaction catalysed
3 malonyl-CoA <=> phloroglucinol + 3 CO(2) + 3 CoA
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase.
  • The mechanism involves the cyclization of an activated 3,5- dioxoheptanedioate intermediate.
  • The enzyme exhibits broad substrate specificity, and can accept C(4)- C(12) aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming C(6)-polyoxoalkylated alpha-pyrones by sequential condensation with malonyl-CoA.
Cross-references
BRENDA2.3.1.253
EC2PDB2.3.1.253
ExplorEnz2.3.1.253
PRIAM enzyme-specific profiles2.3.1.253
KEGG Ligand Database for Enzyme Nomenclature2.3.1.253
IUBMB Enzyme Nomenclature2.3.1.253
IntEnz2.3.1.253
MEDLINEFind literature relating to 2.3.1.253
MetaCyc2.3.1.253
Rhea expert-curated reactions2.3.1.253
UniProtKB/Swiss-Prot
Q4K418, PHLD_PSEF5;  Q51725, PHLD_PSEFL;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-