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ENZYME entry: EC 2.3.1.253

Accepted Name
Phloroglucinol synthase.
Reaction catalysed
3 malonyl-CoA <=> phloroglucinol + 3 CO(2) + 3 CoA
Comment(s)
  • The enzyme, characterized from the bacterium Pseudomonas protegens Pf-5, is a type III polyketide synthase.
  • The mechanism involves the cyclization of an activated 3,5- dioxoheptanedioate intermediate.
  • The enzyme exhibits broad substrate specificity, and can accept C(4)- C(12) aliphatic acyl-CoAs and phenylacetyl-CoA as the starter molecules, forming C(6)-polyoxoalkylated alpha-pyrones by sequential condensation with malonyl-CoA.
Cross-references
BRENDA2.3.1.253
EC2PDB2.3.1.253
ExplorEnz2.3.1.253
PRIAM enzyme-specific profiles2.3.1.253
KEGG Ligand Database for Enzyme Nomenclature2.3.1.253
IUBMB Enzyme Nomenclature2.3.1.253
IntEnz2.3.1.253
MEDLINEFind literature relating to 2.3.1.253
MetaCyc2.3.1.253

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