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ENZYME entry: EC 2.3.1.259

Accepted Name
N-terminal methionine N(alpha)-acetyltransferase NatF.
Reaction catalysed
Acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] <=> an N-terminal-N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA
Comment(s)
  • N-terminal-acetylases (NATs) catalyze the covalent attachment of an acetyl moiety from acetyl-CoA to the free alpha-amino group at the N-terminus of a protein.
  • This irreversible modification neutralizes the positive charge at the N-terminus, makes the N-terminal residue larger and more hydrophobic, and prevents its removal by hydrolysis.
  • NatF is found only in higher eukaryotes, and is absent from yeast.
  • Unlike other Nat systems the enzyme is located in the Golgi apparatus.
  • It faces the cytosolic side of intracellular membranes, and specifically acetylates transmembrane proteins whose N termini face the cytosol.
  • NatF targets N-terminal L-methionine residues attached to Lys, Ser, Val, Leu, Gln, Ile, Tyr and Thr residues.
  • Formerly EC 2.3.1.88.
Cross-references
BRENDA2.3.1.259
EC2PDB2.3.1.259
ExplorEnz2.3.1.259
PRIAM enzyme-specific profiles2.3.1.259
KEGG Ligand Database for Enzyme Nomenclature2.3.1.259
IUBMB Enzyme Nomenclature2.3.1.259
IntEnz2.3.1.259
MEDLINEFind literature relating to 2.3.1.259
MetaCyc2.3.1.259
UniProtKB/Swiss-Prot
Q17QK9, NAA60_BOVIN;  A3KPA3, NAA60_DANRE;  Q95SX8, NAA60_DROME;  
Q9H7X0, NAA60_HUMAN;  Q9DBU2, NAA60_MOUSE;  Q3MHC1, NAA60_RAT;  
A8E5V7, NAA60_XENTR;  

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