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ENZYME

ENZYME entry: EC 2.3.1.26

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.26
Accepted Name
sterol O-acyltransferase
Alternative Name(s)
cholesterol acyltransferase
sterol-ester synthase
Reaction catalysed
a sterol + a long-chain fatty acyl-CoA = a long-chain 3-hydroxysterol ester + CoA
Comment(s)
  • The enzyme catalyzes the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A.
  • The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA.
  • In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol.
  • In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of 'foam cells', a hallmark of early atherosclerotic lesions.
  • In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
Cross-references
BRENDA2.3.1.26
EC2PDB2.3.1.26
ExplorEnz2.3.1.26
KEGG Ligand Database for Enzyme Nomenclature2.3.1.26
IUBMB Enzyme Nomenclature2.3.1.26
MEDLINEFind literature relating to 2.3.1.26
MetaCyc2.3.1.26
Rhea expert-curated reactions2.3.1.26
UniProtKB/Swiss-Prot
O77760, SOAT1_CHLAEQ60457, SOAT1_CRIGRP35610, SOAT1_HUMAN
O77761, SOAT1_MACFAQ61263, SOAT1_MOUSEO70536, SOAT1_RAT
O77759, SOAT2_CHLAEO75908, SOAT2_HUMANO88908, SOAT2_MOUSE
Q7TQM4, SOAT2_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-