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ENZYME entry: EC 2.3.1.26

Accepted Name
Sterol O-acyltransferase.
Alternative Name(s)
Cholesterol acyltransferase.
Sterol-ester synthase.
Reaction catalysed
A long-chain acyl-CoA + a sterol <=> CoA + a long-chain 3-hydroxysterol ester
Comment(s)
  • The enzyme catalyzes the formation of sterol esters from a sterol and long-chain fatty acyl-coenzyme A.
  • The enzyme from yeast, but not from mammals, prefers monounsaturated acyl-CoA.
  • In mammals the enzyme acts mainly on cholesterol and forms cholesterol esters that are stored in cytosolic droplets, which may serve to protect cells from the toxicity of free cholesterol.
  • In macrophages, the accumulation of cytosolic droplets of cholesterol esters results in the formation of 'foam cells', a hallmark of early atherosclerotic lesions.
  • In hepatocytes and enterocytes, cholesterol esters can be incorporated into apolipoprotein B-containing lipoproteins for secretion from the cell.
Cross-references
BRENDA2.3.1.26
EC2PDB2.3.1.26
ExplorEnz2.3.1.26
PRIAM enzyme-specific profiles2.3.1.26
KEGG Ligand Database for Enzyme Nomenclature2.3.1.26
IUBMB Enzyme Nomenclature2.3.1.26
IntEnz2.3.1.26
MEDLINEFind literature relating to 2.3.1.26
MetaCyc2.3.1.26
Rhea expert-curated reactions2.3.1.26
UniProtKB/Swiss-Prot
O77760, SOAT1_CHLAE;  Q60457, SOAT1_CRIGR;  P35610, SOAT1_HUMAN;  
O77761, SOAT1_MACFA;  Q61263, SOAT1_MOUSE;  O70536, SOAT1_RAT;  
O77759, SOAT2_CHLAE;  O75908, SOAT2_HUMAN;  O88908, SOAT2_MOUSE;  
Q7TQM4, SOAT2_RAT;  

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