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ENZYME entry: EC

Accepted Name
Tetracycline polyketide synthase.
Reaction catalysed
Malonamoyl-[OxyC acyl-carrier protein] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + 8 CO(2) + 8 CoA
  • The synthesis, in the bacterium Streptomyces rimosus of the tetracycline antibiotics core skeleton requires a minimal polyketide synthase (PKS) consisting of a ketosynthase (KS), a chain length factor (CLF), and an acyl-carrier protein (ACP).
  • Initiation involves an amide-containing starter unit that becomes the C-2 amide that is present in the tetracycline compounds.
  • Following the initiation, the PKS catalyzes the iterative condensation of 8 malonyl-CoA molecules to yield the polyketide backbone of tetracycline.
  • Throughout the proccess, the nascent chain is attached to the OxyC acyl-carrier protein.
PRIAM enzyme-specific profiles2.3.1.260
KEGG Ligand Database for Enzyme Nomenclature2.3.1.260
IUBMB Enzyme Nomenclature2.3.1.260
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