ENZYME entry: EC 2.3.1.260
Accepted Name |
tetracycline polyketide synthase.
|
Reaction catalysed |
8 H(+) + malonamoyl-[OxyC ACP] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC ACP] + 8 CO2 + 8 CoA |
Comment(s) |
- The synthesis, in the bacterium Streptomyces rimosus of the
tetracycline antibiotics core skeleton requires a minimal polyketide
synthase (PKS) consisting of a ketosynthase (KS), a chain length
factor (CLF), and an acyl-carrier protein (ACP).
- Initiation involves an amide-containing starter unit that becomes the
C-2 amide that is present in the tetracycline compounds.
- Following the initiation, the PKS catalyzes the iterative
condensation of 8 malonyl-CoA molecules to yield the polyketide
backbone of tetracycline.
- Throughout the proccess, the nascent chain is attached to the
OxyC acyl-carrier protein.
|
Cross-references |
BRENDA | 2.3.1.260 |
EC2PDB | 2.3.1.260 |
ExplorEnz | 2.3.1.260 |
PRIAM enzyme-specific profiles | 2.3.1.260 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.260 |
IUBMB Enzyme Nomenclature | 2.3.1.260 |
IntEnz | 2.3.1.260 |
MEDLINE | Find literature relating to 2.3.1.260 |
MetaCyc | 2.3.1.260 |
Rhea expert-curated reactions | 2.3.1.260 |
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