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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.1.260

Accepted Name
Tetracycline polyketide synthase.
Reaction catalysed
Malonamoyl-[OxyC acyl-carrier protein] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + 8 CO(2) + 8 CoA
Comment(s)
  • The synthesis, in the bacterium Streptomyces rimosus of the tetracycline antibiotics core skeleton requires a minimal polyketide synthase (PKS) consisting of a ketosynthase (KS), a chain length factor (CLF), and an acyl-carrier protein (ACP).
  • Initiation involves an amide-containing starter unit that becomes the C-2 amide that is present in the tetracycline compounds.
  • Following the initiation, the PKS catalyzes the iterative condensation of 8 malonyl-CoA molecules to yield the polyketide backbone of tetracycline.
  • Throughout the proccess, the nascent chain is attached to the OxyC acyl-carrier protein.
Cross-references
BRENDA2.3.1.260
EC2PDB2.3.1.260
ExplorEnz2.3.1.260
PRIAM enzyme-specific profiles2.3.1.260
KEGG Ligand Database for Enzyme Nomenclature2.3.1.260
IUBMB Enzyme Nomenclature2.3.1.260
IntEnz2.3.1.260
MEDLINEFind literature relating to 2.3.1.260
MetaCyc2.3.1.260

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-