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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 22.214.171.1240
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|Tetracycline polyketide synthase.
|Malonamoyl-[OxyC acyl-carrier protein] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + 8 CO(2) + 8 CoA|
- The synthesis, in the bacterium Streptomyces rimosus of the
tetracycline antibiotics core skeleton requires a minimal polyketide
synthase (PKS) consisting of a ketosynthase (KS), a chain length
factor (CLF), and an acyl-carrier protein (ACP).
- Initiation involves an amide-containing starter unit that becomes the
C-2 amide that is present in the tetracycline compounds.
- Following the initiation, the PKS catalyzes the iterative
condensation of 8 malonyl-CoA molecules to yield the polyketide
backbone of tetracycline.
- Throughout the proccess, the nascent chain is attached to the
OxyC acyl-carrier protein.
|PRIAM enzyme-specific profiles||126.96.36.1990|
|KEGG Ligand Database for Enzyme Nomenclature||188.8.131.520|
|IUBMB Enzyme Nomenclature||184.108.40.2060|
|MEDLINE||Find literature relating to 220.127.116.110|
entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-