ENZYME entry: EC 2.3.1.260
| Accepted Name |
|---|
| Tetracycline polyketide synthase.
|
| Reaction catalysed |
|---|
| Malonamoyl-[OxyC acyl-carrier protein] + 8 malonyl-CoA <=> 18-carbamoyl-3,5,7,9,11,13,15,17-octaoxooctadecanoyl-[OxyC acyl-carrier protein] + 8 CO(2) + 8 CoA |
| Comment(s) |
|---|
- The synthesis, in the bacterium Streptomyces rimosus of the
tetracycline antibiotics core skeleton requires a minimal polyketide
synthase (PKS) consisting of a ketosynthase (KS), a chain length
factor (CLF), and an acyl-carrier protein (ACP).
- Initiation involves an amide-containing starter unit that becomes the
C-2 amide that is present in the tetracycline compounds.
- Following the initiation, the PKS catalyzes the iterative
condensation of 8 malonyl-CoA molecules to yield the polyketide
backbone of tetracycline.
- Throughout the proccess, the nascent chain is attached to the
OxyC acyl-carrier protein.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.260 |
| EC2PDB | 2.3.1.260 |
| ExplorEnz | 2.3.1.260 |
| PRIAM enzyme-specific profiles | 2.3.1.260 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.260 |
| IUBMB Enzyme Nomenclature | 2.3.1.260 |
| IntEnz | 2.3.1.260 |
| MEDLINE | Find literature relating to 2.3.1.260 |
| MetaCyc | 2.3.1.260 |
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