| Accepted Name |
|---|
| (4-hydroxyphenyl)alkanoate synthase
|
| Reaction catalysed |
|---|
- 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 8 malonyl-CoA + 16 NADPH + 24 H(+) = 17-(4-hydroxyphenyl)heptadecanoyl-[4-hydroxyphenylalkanoate synthase] + 8 CO2 + 16 NADP(+) + 8 CoA + 8 H2O
- 4-hydroxyphenyl-[4-hydroxyphenylalkanoate synthase] + 9 malonyl-CoA + 18 NADPH + 27 H(+) = 19-(4-hydroxyphenyl)nonadecanoyl-[4-hydroxyphenylalkanoate synthase] + 9 CO2 + 18 NADP(+) + 9 CoA + 9 H2O
|
| Comment(s) |
|---|
- The enzyme is part of the biosynthetic pathway of phenolphthiocerol,
a lipid that serves as a virulence factor of pathogenic mycobacteria.
- It catalyzes the elongation of 4-hydroxybenzoate that is loaded on
its acyl-carrier domain to form (4-hydroxyphenyl)alkanoate
intermediates.
- The enzyme adds either 8 or 9 malonyl-CoA units, resulting in
formation of 17-(4-hydroxyphenyl)heptadecanoate or
19-(4-hydroxyphenyl)nonadecanoate, respectively.
- As the enzyme lacks a thioesterase domain, the product remains loaded
on the acyl-carrier domain at the end of catalysis, and has to be
hydrolyzed by an as-yet unknown mechanism.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.261 |
| EC2PDB | 2.3.1.261 |
| ExplorEnz | 2.3.1.261 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.261 |
| IUBMB Enzyme Nomenclature | 2.3.1.261 |
| MEDLINE | Find literature relating to 2.3.1.261 |
| MetaCyc | 2.3.1.261 |
| Rhea expert-curated reactions | 2.3.1.261 |
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