A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 126.96.36.1991
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|Acetyl-CoA + L-glutamate-5-semialdehyde <=> CoA + N-acetyl-L-glutamate 5-semialdehyde|
- The enzyme, characterized from the yeast Saccharomyces cerevisiae
Sigma-1278b, N-acetylates L-glutamate-5-semialdehyde, an L-proline
biosynthesis/utilization intermediate, into N-acetyl-L-glutamate
5-semialdehyde, an intermediate of L-arginine biosynthesis, under
oxidative stress conditions.
- Its activity results in conversion of L-proline to L-arginine,
and reduction in the concentration of L-glutamate 5-semialdehyde and
its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has
been linked to production of reactive oxygen species stress.
- The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic
L-proline analog produced by some plants, resulting in its
detoxification and conferring resistance on the yeast.
|PRIAM enzyme-specific profiles||188.8.131.521|
|KEGG Ligand Database for Enzyme Nomenclature||184.108.40.2061|
|IUBMB Enzyme Nomenclature||220.127.116.111|
|MEDLINE||Find literature relating to 18.104.22.1681|
entries corresponding to 2.3.1.-
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