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ENZYME entry: EC

Accepted Name
L-glutamate-5-semialdehyde N-acetyltransferase.
Reaction catalysed
Acetyl-CoA + L-glutamate-5-semialdehyde <=> CoA + N-acetyl-L-glutamate 5-semialdehyde
  • The enzyme, characterized from the yeast Saccharomyces cerevisiae Sigma-1278b, N-acetylates L-glutamate-5-semialdehyde, an L-proline biosynthesis/utilization intermediate, into N-acetyl-L-glutamate 5-semialdehyde, an intermediate of L-arginine biosynthesis, under oxidative stress conditions.
  • Its activity results in conversion of L-proline to L-arginine, and reduction in the concentration of L-glutamate 5-semialdehyde and its equilibrium partner, (S)-1-pyrroline-5-carboxylate, which has been linked to production of reactive oxygen species stress.
  • The enzyme also acts on (S)-1-acetylazetidine-2-carboxylate, a toxic L-proline analog produced by some plants, resulting in its detoxification and conferring resistance on the yeast.
PRIAM enzyme-specific profiles2.3.1.271
KEGG Ligand Database for Enzyme Nomenclature2.3.1.271
IUBMB Enzyme Nomenclature2.3.1.271
MEDLINEFind literature relating to
Rhea expert-curated reactions2.3.1.271
Q09927, ACA1_SCHPO;  E9P8D2, MPR1_YEASX;  

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