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ENZYME

ENZYME entry: EC 2.3.1.277

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.277
Accepted Name
phosphorylated butenolide synthase
Alternative Name(s)
2-oxo-3-(phosphooxy)propyl 3-oxoalkanoate synthase
Reaction catalysed
a medium-chain 3-oxoacyl-[ACP] + dihydroxyacetone phosphate = a (4-alkanoyl-5-oxo-2,5-dihydrofuran-3-yl)methyl phosphate + holo-[ACP] + H2O
Comment(s)
The enzyme catalyzes the first committed step in the biosynthesis of gamma-butyrolactone, as well as 2-alkyl-4-hydroxymethylfuran-3- carboxylate (methylenomycin furan) autoregulators that control secondary metabolism and morphological development in Streptomyces bacteria.
Cross-references
BRENDA2.3.1.277
EC2PDB2.3.1.277
ExplorEnz2.3.1.277
KEGG Ligand Database for Enzyme Nomenclature2.3.1.277
IUBMB Enzyme Nomenclature2.3.1.277
MEDLINEFind literature relating to 2.3.1.277
MetaCyc2.3.1.277
Rhea expert-curated reactions2.3.1.277
UniProtKB/Swiss-Prot
B1VN93, AFSA_STRGGP18394, AFSA_STRGRO24738, BARX_STRVG
Q7AKF0, SCBA_STRCO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-