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ENZYME entry: EC 2.3.1.279

Accepted Name
long-chain-acyl-CoA--trehalose acyltransferase
Reaction catalysed
a long-chain fatty acyl-CoA + alpha,alpha-trehalose <=> 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose + CoA
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains.
  • The enzyme catalyzes two successive activities - it first transfers an acyl (often palmitoyl) group to position 2, followed by the transfer of a mycolipenyl group to position 3 (see EC 2.3.1.278).
Cross-references
BRENDA2.3.1.279
EC2PDB2.3.1.279
ExplorEnz2.3.1.279
PRIAM enzyme-specific profiles2.3.1.279
KEGG Ligand Database for Enzyme Nomenclature2.3.1.279
IUBMB Enzyme Nomenclature2.3.1.279
IntEnz2.3.1.279
MEDLINEFind literature relating to 2.3.1.279
MetaCyc2.3.1.279
Rhea expert-curated reactions2.3.1.279
UniProtKB/Swiss-Prot
P9WIK4, PAPA3_MYCTOP9WIK5, PAPA3_MYCTU

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