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ENZYME

ENZYME entry: EC 2.3.1.278

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.278
Accepted Name
mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase
Reaction catalysed
a mycolipenoyl-CoA + a 2-O-(long-chain fatty acyl)-alpha,alpha-trehalose = a 2-O-(long-chain fatty acyl)-3-O-mycolipenoyl-trehalose + CoA
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains.
  • The enzyme catalyzes two successive activities - it first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279), followed by the transfer of a mycolipenyl group to position 3.
Cross-references
BRENDA2.3.1.278
EC2PDB2.3.1.278
ExplorEnz2.3.1.278
KEGG Ligand Database for Enzyme Nomenclature2.3.1.278
IUBMB Enzyme Nomenclature2.3.1.278
MEDLINEFind literature relating to 2.3.1.278
MetaCyc2.3.1.278
Rhea expert-curated reactions2.3.1.278
UniProtKB/Swiss-Prot
P9WIK4, PAPA3_MYCTOP9WIK5, PAPA3_MYCTU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-