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ENZYME entry: EC 2.3.1.278

Accepted Name
Mycolipenoyl-CoA--2-(long-chain-fatty acyl)-trehalose mycolipenoyltransferase.
Reaction catalysed
A mycolipenoyl-CoA + a 2-(long-chain-fatty acyl)-trehalose <=> a 2-(long-chain-fatty acyl)-3-mycolipenoyl-trehalose + CoA
Comment(s)
  • The enzyme, characterized from the bacterium Mycobacterium tuberculosis, participates in the biosynthesis of polyacyltrehalose (PAT), a pentaacylated, trehalose-based glycolipid found in the cell wall of pathogenic strains.
  • The enzyme catalyzes two successive activities - it first transfers an acyl (often palmitoyl) group to position 2 (see EC 2.3.1.279), followed by the transfer of a mycolipenyl group to position 3.
Cross-references
BRENDA2.3.1.278
EC2PDB2.3.1.278
ExplorEnz2.3.1.278
PRIAM enzyme-specific profiles2.3.1.278
KEGG Ligand Database for Enzyme Nomenclature2.3.1.278
IUBMB Enzyme Nomenclature2.3.1.278
IntEnz2.3.1.278
MEDLINEFind literature relating to 2.3.1.278
MetaCyc2.3.1.278

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-