Expasy logo

ENZYME

ENZYME entry: EC 2.3.1.281

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.281
Accepted Name
coelimycin P1 polyketide synthase
Reaction catalysed
6 malonyl-CoA + NADH + 5 NADPH + 12 H(+) = (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CO2 + NAD(+) + 5 NADP(+) + 6 CoA + 4 H2O
Comment(s)
  • This polyketide synthase enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), catalyzes the first reaction in the biosynthesis of coelimycin P1.
  • The enzyme is made of three proteins which together comprise six modules that contain a total of 28 domains.
  • An NADH-dependent terminal reductase domain at the C-terminus of the enzyme catalyzes the reductive release of the product.
Cross-references
BRENDA2.3.1.281
EC2PDB2.3.1.281
ExplorEnz2.3.1.281
KEGG Ligand Database for Enzyme Nomenclature2.3.1.281
IUBMB Enzyme Nomenclature2.3.1.281
MEDLINEFind literature relating to 2.3.1.281
MetaCyc2.3.1.281
Rhea expert-curated reactions2.3.1.281

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-