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ENZYME entry: EC 2.3.1.281

Accepted Name
Coelimycin P1 polyketide synthase.
Reaction catalysed
6 malonyl-CoA + 5 NADPH + NADH <=> (2E,5S,6E,8E,10E)-5-hydroxydodeca-2,6,8,10-tetraenal + 6 CoA + 5 NADP(+) + NAD(+) + 6 CO(2) + 4 H(2)O
Comment(s)
  • This polyketide synthase enzyme, characterized from the bacterium Streptomyces coelicolor A3(2), catalyzes the first reaction in the biosynthesis of coelimycin P1.
  • The enzyme is made of three proteins which together comprise six modules that contain a total of 28 domains.
  • An NADH-dependent terminal reductase domain at the C-terminus of the enzyme catalyzes the reductive release of the product.
Cross-references
BRENDA2.3.1.281
EC2PDB2.3.1.281
ExplorEnz2.3.1.281
PRIAM enzyme-specific profiles2.3.1.281
KEGG Ligand Database for Enzyme Nomenclature2.3.1.281
IUBMB Enzyme Nomenclature2.3.1.281
IntEnz2.3.1.281
MEDLINEFind literature relating to 2.3.1.281
MetaCyc2.3.1.281
Rhea expert-curated reactions2.3.1.281

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