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ENZYME entry: EC 2.3.1.286

Accepted Name
Protein acetyllysine N-acetyltransferase.
Alternative Name(s)
NAD(+)-dependent protein deacetylase.
Protein lysine deacetylase.
Reaction catalysed
[Protein]-N(6)-acetyl-L-lysine + NAD(+) + H(2)O <=> [protein]-L-lysine + 2''-O-acetyl-ADP-D-ribose + nicotinamide
Comment(s)
  • The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins.
  • Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
Cross-references
BRENDA2.3.1.286
EC2PDB2.3.1.286
ExplorEnz2.3.1.286
PRIAM enzyme-specific profiles2.3.1.286
KEGG Ligand Database for Enzyme Nomenclature2.3.1.286
IUBMB Enzyme Nomenclature2.3.1.286
IntEnz2.3.1.286
MEDLINEFind literature relating to 2.3.1.286
MetaCyc2.3.1.286
UniProtKB/Swiss-Prot
Q5AQ47, HST1_CANAL;  C8V3W5, HST1_EMENI;  P53685, HST1_YEAST;  
Q5AW69, HST21_EMENI;  P0CS88, HST22_EMENI;  Q5A985, HST2_CANAL;  
Q9USN7, HST2_SCHPO;  P53686, HST2_YEAST;  Q5A1W9, HST3_CANAL;  
P53687, HST3_YEAST;  Q5BE04, HST4_EMENI;  Q9UR39, HST4_SCHPO;  
P53688, HST4_YEAST;  A0R2N3, NDP_MYCS2;  O28597, NPD1_ARCFU;  
Q89LY4, NPD1_BRADU;  Q8R9N6, NPD1_CALS4;  Q8FUC8, NPD1_COREF;  
Q5L014, NPD1_GEOKA;  A0QDH4, NPD1_MYCA1;  Q9I4L0, NPD1_PSEAE;  
Q88A13, NPD1_PSESM;  Q8ZU41, NPD1_PYRAE;  Q9RL35, NPD1_STRCO;  
O30124, NPD2_ARCFU;  Q89EA6, NPD2_BRADU;  Q8R984, NPD2_CALS4;  
Q8FRV5, NPD2_COREF;  Q5KZE8, NPD2_GEOKA;  A0QC96, NPD2_MYCA1;  
Q9I4E1, NPD2_PSEAE;  Q885X7, NPD2_PSESM;  Q8ZT00, NPD2_PYRAE;  
Q8CJM9, NPD2_STRCO;  Q882K4, NPD3_PSESM;  Q87W79, NPD4_PSESM;  
Q9YB13, NPD_AERPE;  Q9ZAB8, NPD_AGGAC;  O67919, NPD_AQUAE;  
Q81NT6, NPD_BACAN;  Q735N7, NPD_BACC1;  Q81BT4, NPD_BACCR;  
Q639M6, NPD_BACCZ;  Q9KEE5, NPD_BACHD;  Q6HH09, NPD_BACHK;  
Q5WKC8, NPD_BACSK;  O07595, NPD_BACSU;  Q8A3H9, NPD_BACTN;  
Q6MJJ2, NPD_BDEBA;  Q7WLE5, NPD_BORBR;  Q7VX46, NPD_BORPE;  
A8MBU4, NPD_CALMQ;  Q9JN05, NPD_CAMJE;  Q5HU51, NPD_CAMJR;  
Q9A2S6, NPD_CAUVC;  Q7P1B9, NPD_CHRVO;  Q97MB4, NPD_CLOAB;  
Q8XNS6, NPD_CLOPE;  Q899G3, NPD_CLOTE;  Q8NSM4, NPD_CORGL;  
Q6A5T5, NPD_CUTAK;  Q9RYD4, NPD_DEIRA;  A9A0B2, NPD_DESOH;  
Q8X8E0, NPD_ECO57;  Q8FIM4, NPD_ECOL6;  P75960, NPD_ECOLI;  
Q839C6, NPD_ENTFA;  Q8REC3, NPD_FUSNN;  Q5V4Q5, NPD_HALMA;  
Q7VIN2, NPD_HELHP;  Q9ZJW8, NPD_HELPJ;  O25849, NPD_HELPY;  
Q88ZA0, NPD_LACPL;  C1DBX3, NPD_LARHH;  Q72RR0, NPD_LEPIC;  
Q8F3Z6, NPD_LEPIN;  Q927A7, NPD_LISIN;  Q71W25, NPD_LISMF;  
Q8Y3U2, NPD_LISMO;  Q607X6, NPD_METCA;  Q8TWG0, NPD_METKA;  
P66814, NPD_MYCBO;  Q9CBW6, NPD_MYCLE;  Q73WM7, NPD_MYCPA;  
P9WGG2, NPD_MYCTO;  P9WGG3, NPD_MYCTU;  Q8ELR0, NPD_OCEIH;  
Q9CM50, NPD_PASMU;  Q88BY5, NPD_PSEPK;  Q9UZE7, NPD_PYRAB;  
Q8U1Q1, NPD_PYRFU;  O58669, NPD_PYRHO;  Q8Y015, NPD_RALSO;  
Q7UFQ9, NPD_RHOBA;  Q6N6U0, NPD_RHOPA;  Q97VX5, NPD_SACS2;  
P0A2F3, NPD_SALTI;  P0A2F2, NPD_SALTY;  Q8EFN2, NPD_SHEON;  
Q83RR8, NPD_SHIFL;  Q53700, NPD_STAA8;  Q5HE07, NPD_STAAC;  
P66815, NPD_STAAM;  P66816, NPD_STAAN;  Q6GEN2, NPD_STAAR;  
Q6G7B7, NPD_STAAS;  Q8NVC8, NPD_STAAW;  Q5HM33, NPD_STAEQ;  
Q8CNF4, NPD_STAES;  Q4JBN2, NPD_SULAC;  Q974M6, NPD_SULTO;  
Q67KQ0, NPD_SYMTH;  Q5JG47, NPD_THEKO;  Q9WYW0, NPD_THEMA;  
C6A243, NPD_THESM;  Q72IV5, NPD_THET2;  Q5SIH7, NPD_THET8;  
B5YJW3, NPD_THEYD;  Q73KE1, NPD_TREDE;  Q9KRX4, NPD_VIBCH;  
Q87PH8, NPD_VIBPA;  Q8D9J9, NPD_VIBVU;  Q7MKT7, NPD_VIBVY;  
Q8PQK3, NPD_XANAC;  Q4UZX0, NPD_XANC8;  B0RM75, NPD_XANCB;  
Q8PDM9, NPD_XANCP;  Q8ZFR1, NPD_YERPE;  Q669P6, NPD_YERPS;  
Q9FE17, SIR1_ARATH;  Q96EB6, SIR1_HUMAN;  Q923E4, SIR1_MOUSE;  
B8ARK7, SIR1_ORYSI;  A0A0G2JZ79, SIR1_RAT;  Q95Q89, SIR24_CAEEL;  
Q54QE6, SIR2A_DICDI;  Q54LF0, SIR2B_DICDI;  Q8IKW2, SIR2B_PLAF7;  
Q54P49, SIR2C_DICDI;  Q54GV7, SIR2D_DICDI;  Q55DB0, SIR2E_DICDI;  
Q757M7, SIR2_ASHGO;  Q60L58, SIR2_CAEBR;  Q21921, SIR2_CAEEL;  
O59923, SIR2_CANAL;  Q6FWI7, SIR2_CANGA;  Q7ZVK3, SIR2_DANRE;  
Q8IXJ6, SIR2_HUMAN;  P33294, SIR2_KLULA;  Q25337, SIR2_LEIMA;  
Q4R834, SIR2_MACFA;  Q8VDQ8, SIR2_MOUSE;  Q5RBF1, SIR2_PONAB;  
Q5RJQ4, SIR2_RAT;  O94640, SIR2_SCHPO;  Q57V41, SIR2_TRYB2;  
P06700, SIR2_YEAST;  Q9NTG7, SIR3_HUMAN;  Q8R104, SIR3_MOUSE;  
Q20480, SIR41_CAEEL;  Q20481, SIR42_CAEEL;  Q94AQ6, SIR4_ARATH;  
F4P804, SIR4_BATDJ;  Q1JQC6, SIR4_BOVIN;  Q8IRR5, SIR4_DROME;  
Q9Y6E7, SIR4_HUMAN;  Q4QB33, SIR4_LEIMA;  A9UVV1, SIR4_MONBE;  
Q8R216, SIR4_MOUSE;  Q57YZ9, SIR4_TRYB2;  Q9VH08, SIR6_DROME;  
Q8N6T7, SIR6_HUMAN;  P59941, SIR6_MOUSE;  Q0P595, SIR7_BOVIN;  
Q9VAQ1, SIR7_DROME;  Q9NRC8, SIR7_HUMAN;  Q8BKJ9, SIR7_MOUSE;  
B2RZ55, SIR7_RAT;  Q9VK34, SIRT1_DROME;  Q9I7I7, SIRT2_DROME;  

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