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ENZYME

ENZYME entry: EC 2.3.1.286

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.286
Accepted Name
protein acetyllysine N-acetyltransferase
Alternative Name(s)
NAD(+)-dependent protein deacetylase
protein lysine deacetylase
Reaction catalysed
N(6)-acetyl-L-lysyl-[protein] + NAD(+) + H2O = 2''-O-acetyl-ADP-D-ribose + nicotinamide + L-lysyl-[protein]
Comment(s)
  • The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins.
  • Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
Cross-references
Rhea expert-curated reactions2.3.1.286
ExplorEnz2.3.1.286
IUBMB Enzyme Nomenclature2.3.1.286
UniProtKB/Swiss-Prot
Q5AQ47, HST1_CANALC8V3W5, HST1_EMENIP53685, HST1_YEAST
Q5AW69, HST21_EMENIP0CS88, HST22_EMENIQ5A985, HST2_CANAL
Q9USN7, HST2_SCHPOP53686, HST2_YEASTQ5A1W9, HST3_CANAL
P53687, HST3_YEASTQ5BE04, HST4_EMENIQ9UR39, HST4_SCHPO
P53688, HST4_YEASTA0R2N3, NDP_MYCS2O28597, NPD1_ARCFU
Q89LY4, NPD1_BRADUQ8R9N6, NPD1_CALS4Q8FUC8, NPD1_COREF
Q5L014, NPD1_GEOKAA0QDH4, NPD1_MYCA1Q9I4L0, NPD1_PSEAE
Q88A13, NPD1_PSESMQ8ZU41, NPD1_PYRAEQ9RL35, NPD1_STRCO
O30124, NPD2_ARCFUQ89EA6, NPD2_BRADUQ8R984, NPD2_CALS4
Q8FRV5, NPD2_COREFQ5KZE8, NPD2_GEOKAA0QC96, NPD2_MYCA1
Q9I4E1, NPD2_PSEAEQ885X7, NPD2_PSESMQ8ZT00, NPD2_PYRAE
Q8CJM9, NPD2_STRCOQ882K4, NPD3_PSESMQ87W79, NPD4_PSESM
Q9YB13, NPD_AERPEQ9ZAB8, NPD_AGGACO67919, NPD_AQUAE
Q81NT6, NPD_BACANQ735N7, NPD_BACC1Q81BT4, NPD_BACCR
Q639M6, NPD_BACCZQ6HH09, NPD_BACHKO07595, NPD_BACSU
Q8A3H9, NPD_BACTNQ6MJJ2, NPD_BDEBAQ7WLE5, NPD_BORBR
Q7VX46, NPD_BORPEA8MBU4, NPD_CALMQQ9JN05, NPD_CAMJE
Q5HU51, NPD_CAMJRQ9A2S6, NPD_CAUVCQ7P1B9, NPD_CHRVO
Q97MB4, NPD_CLOABQ8XNS6, NPD_CLOPEQ899G3, NPD_CLOTE
Q8NSM4, NPD_CORGLQ6A5T5, NPD_CUTAKQ9RYD4, NPD_DEIRA
A9A0B2, NPD_DESOHQ8X8E0, NPD_ECO57Q8FIM4, NPD_ECOL6
P75960, NPD_ECOLIQ839C6, NPD_ENTFAQ8REC3, NPD_FUSNN
Q9KEE5, NPD_HALH5Q5V4Q5, NPD_HALMAQ7VIN2, NPD_HELHP
Q9ZJW8, NPD_HELPJO25849, NPD_HELPYQ88ZA0, NPD_LACPL
C1DBX3, NPD_LARHHQ72RR0, NPD_LEPICQ8F3Z6, NPD_LEPIN
Q927A7, NPD_LISINQ71W25, NPD_LISMFQ8Y3U2, NPD_LISMO
Q607X6, NPD_METCAQ8TWG0, NPD_METKAP66814, NPD_MYCBO
Q9CBW6, NPD_MYCLEQ73WM7, NPD_MYCPAA5U1J9, NPD_MYCTA
P9WGG2, NPD_MYCTOP9WGG3, NPD_MYCTUQ8ELR0, NPD_OCEIH
Q9CM50, NPD_PASMUB4EVF5, NPD_PROMHQ88BY5, NPD_PSEPK
Q9UZE7, NPD_PYRABQ8U1Q1, NPD_PYRFUO58669, NPD_PYRHO
Q8Y015, NPD_RALN1Q7UFQ9, NPD_RHOBAQ6N6U0, NPD_RHOPA
Q97VX5, NPD_SACS2P0A2F3, NPD_SALTIP0A2F2, NPD_SALTY
Q8EFN2, NPD_SHEONQ83RR8, NPD_SHIFLQ5WKC8, NPD_SHOC1
Q53700, NPD_STAA8Q5HE07, NPD_STAACP66815, NPD_STAAM
P66816, NPD_STAANQ6GEN2, NPD_STAARQ6G7B7, NPD_STAAS
Q8NVC8, NPD_STAAWQ5HM33, NPD_STAEQQ8CNF4, NPD_STAES
Q4JBN2, NPD_SULACQ974M6, NPD_SULTOQ67KQ0, NPD_SYMTH
Q5JG47, NPD_THEKOQ9WYW0, NPD_THEMAC6A243, NPD_THESM
Q72IV5, NPD_THET2Q5SIH7, NPD_THET8B5YJW3, NPD_THEYD
Q73KE1, NPD_TREDEQ9KRX4, NPD_VIBCHQ87PH8, NPD_VIBPA
Q8D9J9, NPD_VIBVUQ7MKT7, NPD_VIBVYQ8PQK3, NPD_XANAC
Q4UZX0, NPD_XANC8B0RM75, NPD_XANCBQ8PDM9, NPD_XANCP
Q8ZFR1, NPD_YERPEQ669P6, NPD_YERPSQ9FE17, SIR1_ARATH
Q96EB6, SIR1_HUMANQ923E4, SIR1_MOUSEA0A0G2JZ79, SIR1_RAT
Q95Q89, SIR24_CAEELQ54QE6, SIR2A_DICDIQ54LF0, SIR2B_DICDI
Q8IKW2, SIR2B_PLAF7Q54P49, SIR2C_DICDIQ54GV7, SIR2D_DICDI
Q55DB0, SIR2E_DICDIQ60L58, SIR2_CAEBRQ21921, SIR2_CAEEL
O59923, SIR2_CANALQ6FWI7, SIR2_CANGAQ7ZVK3, SIR2_DANRE
Q757M7, SIR2_EREGSQ8IXJ6, SIR2_HUMANP33294, SIR2_KLULA
Q25337, SIR2_LEIMAQ4R834, SIR2_MACFAQ8VDQ8, SIR2_MOUSE
Q5RBF1, SIR2_PONABQ5RJQ4, SIR2_RATO94640, SIR2_SCHPO
Q57V41, SIR2_TRYB2P06700, SIR2_YEASTQ9NTG7, SIR3_HUMAN
Q8R104, SIR3_MOUSEQ20480, SIR41_CAEELQ20481, SIR42_CAEEL
Q94AQ6, SIR4_ARATHF4P804, SIR4_BATDJQ1JQC6, SIR4_BOVIN
Q8IRR5, SIR4_DROMEQ9Y6E7, SIR4_HUMANQ4QB33, SIR4_LEIMA
A9UVV1, SIR4_MONBEQ8R216, SIR4_MOUSEQ57YZ9, SIR4_TRYB2
A0A0J9UVG7, SIR5_FUSO4A0A250YGJ5, SIR6_CASCNQ9VH08, SIR6_DROME
Q8N6T7, SIR6_HUMANA0A2K5TU92, SIR6_MACFAP59941, SIR6_MOUSE
Q0P595, SIR7_BOVINQ9VAQ1, SIR7_DROMEQ9NRC8, SIR7_HUMAN
Q8BKJ9, SIR7_MOUSEB2RZ55, SIR7_RATQ9VK34, SIRT1_DROME
Q9I7I7, SIRT2_DROMEB8ARK7, SRT1_ORYSIQ7XWV4, SRT1_ORYSJ
BRENDA2.3.1.286
MetaCyc2.3.1.286
KEGG Ligand Database for Enzyme Nomenclature2.3.1.286
EC2PDB2.3.1.286
MEDLINEFind literature relating to 2.3.1.286

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-