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ENZYME

ENZYME entry: EC 2.3.1.286

Accepted Name
protein acetyllysine N-acetyltransferase
Alternative Name(s)
NAD(+)-dependent protein deacetylase
protein lysine deacetylase
Reaction catalysed
H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) <=> 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
Comment(s)
  • The enzyme, found in all domains of life, is involved in gene regulation by deacetylating proteins.
  • Some of the 2''-O-acetyl-ADP-D-ribose converts non-enzymically to 3''-O-acetyl-ADP-D-ribose.
Cross-references
BRENDA2.3.1.286
EC2PDB2.3.1.286
ExplorEnz2.3.1.286
PRIAM enzyme-specific profiles2.3.1.286
KEGG Ligand Database for Enzyme Nomenclature2.3.1.286
IUBMB Enzyme Nomenclature2.3.1.286
IntEnz2.3.1.286
MEDLINEFind literature relating to 2.3.1.286
MetaCyc2.3.1.286
Rhea expert-curated reactions2.3.1.286
UniProtKB/Swiss-Prot
Q5AQ47, HST1_CANALC8V3W5, HST1_EMENIP53685, HST1_YEAST
Q5AW69, HST21_EMENIP0CS88, HST22_EMENIQ5A985, HST2_CANAL
Q9USN7, HST2_SCHPOP53686, HST2_YEASTQ5A1W9, HST3_CANAL
P53687, HST3_YEASTQ5BE04, HST4_EMENIQ9UR39, HST4_SCHPO
P53688, HST4_YEASTA0R2N3, NDP_MYCS2O28597, NPD1_ARCFU
Q89LY4, NPD1_BRADUQ8R9N6, NPD1_CALS4Q8FUC8, NPD1_COREF
Q5L014, NPD1_GEOKAA0QDH4, NPD1_MYCA1Q9I4L0, NPD1_PSEAE
Q88A13, NPD1_PSESMQ8ZU41, NPD1_PYRAEQ9RL35, NPD1_STRCO
O30124, NPD2_ARCFUQ89EA6, NPD2_BRADUQ8R984, NPD2_CALS4
Q8FRV5, NPD2_COREFQ5KZE8, NPD2_GEOKAA0QC96, NPD2_MYCA1
Q9I4E1, NPD2_PSEAEQ885X7, NPD2_PSESMQ8ZT00, NPD2_PYRAE
Q8CJM9, NPD2_STRCOQ882K4, NPD3_PSESMQ87W79, NPD4_PSESM
Q9YB13, NPD_AERPEQ9ZAB8, NPD_AGGACQ5WKC8, NPD_ALKCK
O67919, NPD_AQUAEQ81NT6, NPD_BACANQ735N7, NPD_BACC1
Q81BT4, NPD_BACCRQ639M6, NPD_BACCZQ6HH09, NPD_BACHK
O07595, NPD_BACSUQ8A3H9, NPD_BACTNQ6MJJ2, NPD_BDEBA
Q7WLE5, NPD_BORBRQ7VX46, NPD_BORPEA8MBU4, NPD_CALMQ
Q9JN05, NPD_CAMJEQ5HU51, NPD_CAMJRQ9A2S6, NPD_CAUVC
Q7P1B9, NPD_CHRVOQ97MB4, NPD_CLOABQ8XNS6, NPD_CLOPE
Q899G3, NPD_CLOTEQ8NSM4, NPD_CORGLQ6A5T5, NPD_CUTAK
Q9RYD4, NPD_DEIRAA9A0B2, NPD_DESOHQ8X8E0, NPD_ECO57
Q8FIM4, NPD_ECOL6P75960, NPD_ECOLIQ839C6, NPD_ENTFA
Q8REC3, NPD_FUSNNQ9KEE5, NPD_HALH5Q5V4Q5, NPD_HALMA
Q7VIN2, NPD_HELHPQ9ZJW8, NPD_HELPJO25849, NPD_HELPY
Q88ZA0, NPD_LACPLC1DBX3, NPD_LARHHQ72RR0, NPD_LEPIC
Q8F3Z6, NPD_LEPINQ927A7, NPD_LISINQ71W25, NPD_LISMF
Q8Y3U2, NPD_LISMOQ607X6, NPD_METCAQ8TWG0, NPD_METKA
P66814, NPD_MYCBOQ9CBW6, NPD_MYCLEQ73WM7, NPD_MYCPA
P9WGG2, NPD_MYCTOP9WGG3, NPD_MYCTUQ8ELR0, NPD_OCEIH
Q9CM50, NPD_PASMUB4EVF5, NPD_PROMHQ88BY5, NPD_PSEPK
Q9UZE7, NPD_PYRABQ8U1Q1, NPD_PYRFUO58669, NPD_PYRHO
Q8Y015, NPD_RALSOQ7UFQ9, NPD_RHOBAQ6N6U0, NPD_RHOPA
Q97VX5, NPD_SACS2P0A2F3, NPD_SALTIP0A2F2, NPD_SALTY
Q8EFN2, NPD_SHEONQ83RR8, NPD_SHIFLQ53700, NPD_STAA8
Q5HE07, NPD_STAACP66815, NPD_STAAMP66816, NPD_STAAN
Q6GEN2, NPD_STAARQ6G7B7, NPD_STAASQ8NVC8, NPD_STAAW
Q5HM33, NPD_STAEQQ8CNF4, NPD_STAESQ4JBN2, NPD_SULAC
Q974M6, NPD_SULTOQ67KQ0, NPD_SYMTHQ5JG47, NPD_THEKO
Q9WYW0, NPD_THEMAC6A243, NPD_THESMQ72IV5, NPD_THET2
Q5SIH7, NPD_THET8B5YJW3, NPD_THEYDQ73KE1, NPD_TREDE
Q9KRX4, NPD_VIBCHQ87PH8, NPD_VIBPAQ8D9J9, NPD_VIBVU
Q7MKT7, NPD_VIBVYQ8PQK3, NPD_XANACQ4UZX0, NPD_XANC8
B0RM75, NPD_XANCBQ8PDM9, NPD_XANCPQ8ZFR1, NPD_YERPE
Q669P6, NPD_YERPSQ9FE17, SIR1_ARATHQ96EB6, SIR1_HUMAN
Q923E4, SIR1_MOUSEA0A0G2JZ79, SIR1_RATQ95Q89, SIR24_CAEEL
Q54QE6, SIR2A_DICDIQ54LF0, SIR2B_DICDIQ8IKW2, SIR2B_PLAF7
Q54P49, SIR2C_DICDIQ54GV7, SIR2D_DICDIQ55DB0, SIR2E_DICDI
Q757M7, SIR2_ASHGOQ60L58, SIR2_CAEBRQ21921, SIR2_CAEEL
O59923, SIR2_CANALQ6FWI7, SIR2_CANGBQ7ZVK3, SIR2_DANRE
Q8IXJ6, SIR2_HUMANP33294, SIR2_KLULCQ25337, SIR2_LEIMA
Q4R834, SIR2_MACFAQ8VDQ8, SIR2_MOUSEQ5RBF1, SIR2_PONAB
Q5RJQ4, SIR2_RATO94640, SIR2_SCHPOQ57V41, SIR2_TRYB2
P06700, SIR2_YEASTQ9NTG7, SIR3_HUMANQ8R104, SIR3_MOUSE
Q20480, SIR41_CAEELQ20481, SIR42_CAEELQ94AQ6, SIR4_ARATH
F4P804, SIR4_BATDJQ1JQC6, SIR4_BOVINQ8IRR5, SIR4_DROME
Q9Y6E7, SIR4_HUMANQ4QB33, SIR4_LEIMAA9UVV1, SIR4_MONBE
Q8R216, SIR4_MOUSEQ57YZ9, SIR4_TRYB2A0A250YGJ5, SIR6_CASCN
Q9VH08, SIR6_DROMEQ8N6T7, SIR6_HUMANA0A2K5TU92, SIR6_MACFA
P59941, SIR6_MOUSEQ0P595, SIR7_BOVINQ9VAQ1, SIR7_DROME
Q9NRC8, SIR7_HUMANQ8BKJ9, SIR7_MOUSEB2RZ55, SIR7_RAT
Q9VK34, SIRT1_DROMEQ9I7I7, SIRT2_DROMEB8ARK7, SRT1_ORYSI
Q7XWV4, SRT1_ORYSJ

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-