ENZYME entry: EC 2.3.1.287
| Accepted Name |
|---|
| Phthioceranic/hydroxyphthioceranic acid synthase.
|
| Alternative Name(s) |
|---|
| PKS2. |
| Reaction catalysed |
|---|
- 8 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> 8 CoA + C(40)-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 16 NADP(+) + 8 CO(2) + 8 H(2)O
- 7 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> 7 CoA + C(37)-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 14 NADP(+) + 7 CO(2) + 7 H(2)O
|
| Comment(s) |
|---|
- This mycobacterial polyketide enzyme produces the hepta- and octa-
methylated fatty acids known as phthioceranic acids, and presumably
their hydroxylated versions.
- Formation of hepta- and octamethylated products depends on whether
the enzyme incorporates seven or eight methylmalonyl-CoA extender
units, respectively.
- Formation of hydroxylated products may result from the enzyme
skipping the dehydratase (DH) and enoylreductase (ER) domains during
the first cycle of condensation.
|
| Cross-references |
|---|
| BRENDA | 2.3.1.287 |
| EC2PDB | 2.3.1.287 |
| ExplorEnz | 2.3.1.287 |
| PRIAM enzyme-specific profiles | 2.3.1.287 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.1.287 |
| IUBMB Enzyme Nomenclature | 2.3.1.287 |
| IntEnz | 2.3.1.287 |
| MEDLINE | Find literature relating to 2.3.1.287 |
| MetaCyc | 2.3.1.287 |
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-