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ENZYME entry: EC 2.3.1.287

Accepted Name
Phthioceranic/hydroxyphthioceranic acid synthase.
Alternative Name(s)
PKS2.
Reaction catalysed
  • 8 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 16 NADPH <=> 8 CoA + C(40)-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 16 NADP(+) + 8 CO(2) + 8 H(2)O
  • 7 (S)-methylmalonyl-CoA + palmitoyl-[(hydroxy)phthioceranic acid synthase] + 14 NADPH <=> 7 CoA + C(37)-phthioceranyl-[(hydroxy)phthioceranic acid synthase] + 14 NADP(+) + 7 CO(2) + 7 H(2)O
Comment(s)
  • This mycobacterial polyketide enzyme produces the hepta- and octa- methylated fatty acids known as phthioceranic acids, and presumably their hydroxylated versions.
  • Formation of hepta- and octamethylated products depends on whether the enzyme incorporates seven or eight methylmalonyl-CoA extender units, respectively.
  • Formation of hydroxylated products may result from the enzyme skipping the dehydratase (DH) and enoylreductase (ER) domains during the first cycle of condensation.
Cross-references
BRENDA2.3.1.287
EC2PDB2.3.1.287
ExplorEnz2.3.1.287
PRIAM enzyme-specific profiles2.3.1.287
KEGG Ligand Database for Enzyme Nomenclature2.3.1.287
IUBMB Enzyme Nomenclature2.3.1.287
IntEnz2.3.1.287
MEDLINEFind literature relating to 2.3.1.287
MetaCyc2.3.1.287
Rhea expert-curated reactions2.3.1.287
UniProtKB/Swiss-Prot
Q7TVK8, PHAS_MYCBO;  A1KQG0, PHAS_MYCBP;  A5U9F4, PHAS_MYCTA;  
P9WQE8, PHAS_MYCTO;  P9WQE9, PHAS_MYCTU;  

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