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ENZYME entry: EC 2.3.1.290

Accepted Name
Spectinabilin polyketide synthase system.
Alternative Name(s)
Spectinabilin polyketide synthase complex.
Reaction catalysed
4-nitrobenzoyl-CoA + malonyl-CoA + 6 (S)-methylmalonyl-CoA + 6 NADPH <=> demethyldeoxyspectinabilin + 7 CO(2) + 8 CoA + 6 NADP(+) + 5 H(2)O
Comment(s)
  • This polyketide synthase, characterized from the bacteria Streptomyces orinoci and Streptomyces spectabilis, generates the backbone of the antibiotic spectinabilin.
  • It is composed of 6 modules that total 28 domains and is encoded by four genes.
  • The enzyme accepts the unusual starter unit 4-nitrobenzoyl-CoA and extends it by 6 molecules of (S)-methylmalonyl-CoA and a single molecule of malonyl-CoA.
  • The first module (encoded by norA) is used twice in an iterative fashion, so that the seven Claisen condensation reactions are catalyzed by only six modules.
  • The iteration becomes possible by the transfer of the [acp]-bound polyketide intermediate back to the ketosynthase (KS) domain on the opposite polyketide synthase strand (polyketides are homodimeric).
Cross-references
BRENDA2.3.1.290
EC2PDB2.3.1.290
ExplorEnz2.3.1.290
PRIAM enzyme-specific profiles2.3.1.290
KEGG Ligand Database for Enzyme Nomenclature2.3.1.290
IUBMB Enzyme Nomenclature2.3.1.290
IntEnz2.3.1.290
MEDLINEFind literature relating to 2.3.1.290
MetaCyc2.3.1.290
Rhea expert-curated reactions2.3.1.290

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