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ENZYME entry: EC 2.3.1.291

Accepted Name
Sphingoid base N-palmitoyltransferase.
Alternative Name(s)
Mammalian ceramide synthase 5.
Reaction catalysed
Palmitoyl-CoA + a sphingoid base <=> an N-(palmitoyl)-sphingoid base + CoA
Comment(s)
  • Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates.
  • Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor.
  • It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
Cross-references
BRENDA2.3.1.291
EC2PDB2.3.1.291
ExplorEnz2.3.1.291
PRIAM enzyme-specific profiles2.3.1.291
KEGG Ligand Database for Enzyme Nomenclature2.3.1.291
IUBMB Enzyme Nomenclature2.3.1.291
IntEnz2.3.1.291
MEDLINEFind literature relating to 2.3.1.291
MetaCyc2.3.1.291
Rhea expert-curated reactions2.3.1.291
UniProtKB/Swiss-Prot
Q9LJK3, LOH2_ARATH

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