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ENZYME

ENZYME entry: EC 2.3.1.291

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.291
Accepted Name
sphingoid base N-palmitoyltransferase
Alternative Name(s)
mammalian ceramide synthase 5
Reaction catalysed
a sphingoid base + hexadecanoyl-CoA = an N-hexadecanoyl-sphingoid base + CoA + H(+)
Comment(s)
  • Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates.
  • Ceramide synthase 5 (CERS5) is specific for palmitoyl-CoA as the acyl donor.
  • It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
Cross-references
BRENDA2.3.1.291
EC2PDB2.3.1.291
ExplorEnz2.3.1.291
KEGG Ligand Database for Enzyme Nomenclature2.3.1.291
IUBMB Enzyme Nomenclature2.3.1.291
MEDLINEFind literature relating to 2.3.1.291
MetaCyc2.3.1.291
Rhea expert-curated reactions2.3.1.291
UniProtKB/Swiss-Prot
Q8N5B7, CERS5_HUMANQ9D6K9, CERS5_MOUSEQ6ZMG9, CERS6_HUMAN
Q8C172, CERS6_MOUSEQ9LJK3, LOH2_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-