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ENZYME entry: EC 2.3.1.295

Accepted Name
Mycoketide-CoA synthase.
Reaction catalysed
A medium-chain acyl-CoA + 5 malonyl-CoA + 5 (S)-methylmalonyl-CoA + 22 NADPH <=> a mycoketide-CoA + 10 CO(2) + 10 CoA + 22 NADP(+) + 11 H(2)O
Comment(s)
  • The enzyme, found in mycobacteria, is involved in the synthesis of beta-D-mannosyl phosphomycoketides.
  • It is a very large polyketide synthase that contains two complete sets of FAS-like fatty acid synthase modules.
  • It binds an acyl-CoA with 5-9 carbons as a starter unit, and extends it by five rounds of alternative additions of malonyl-CoA and methylmalonyl-CoA extender units.
  • Depending on the starter unit, the enzyme forms mycoketide-CoAs of different lengths.
Cross-references
BRENDA2.3.1.295
EC2PDB2.3.1.295
ExplorEnz2.3.1.295
PRIAM enzyme-specific profiles2.3.1.295
KEGG Ligand Database for Enzyme Nomenclature2.3.1.295
IUBMB Enzyme Nomenclature2.3.1.295
IntEnz2.3.1.295
MEDLINEFind literature relating to 2.3.1.295
MetaCyc2.3.1.295
Rhea expert-curated reactions2.3.1.295
UniProtKB/Swiss-Prot
I6XD69, PKS12_MYCTU

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