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ENZYME entry: EC 2.3.1.299

Accepted Name
Sphingoid base N-stearoyltransferase.
Alternative Name(s)
Mammalian ceramide synthase 1.
Reaction catalysed
Stearoyl-CoA + a sphingoid base <=> an N-(stearoyl)-sphingoid base + CoA
Comment(s)
  • Mammals have six ceramide synthases that exhibit relatively strict specificity regarding the chain-length of their acyl-CoA substrates.
  • Ceramide synthase 1 (CERS1) is structurally and functionally distinctive from all other CERS enzymes, and is specific for stearoyl-CoA as the acyl donor.
  • It can use multiple sphingoid bases including sphinganine, sphingosine, and phytosphingosine.
Cross-references
BRENDA2.3.1.299
EC2PDB2.3.1.299
ExplorEnz2.3.1.299
PRIAM enzyme-specific profiles2.3.1.299
KEGG Ligand Database for Enzyme Nomenclature2.3.1.299
IUBMB Enzyme Nomenclature2.3.1.299
IntEnz2.3.1.299
MEDLINEFind literature relating to 2.3.1.299
MetaCyc2.3.1.299
Rhea expert-curated reactions2.3.1.299

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