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ENZYME

ENZYME entry: EC 2.3.1.305

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.305
Accepted Name
acyl-[acyl-carrier protein]--UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D- glucopyranose N-acyltransferase
Reaction catalysed
UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucopyranose + a (3R)-hydroxyacyl-[ACP] = a UDP-2-acetamido-3-{[(3R)-3-hydroxyacyl]amino}-2,3-dideoxy-alpha-D-glucopyranose + holo-[ACP] + H(+)
Comment(s)
  • The enzyme is found in bacterial species whose lipid A contains 2,3- diamino-2,3-dideoxy-D-glucopyranose.
  • Some enzymes, such as that from Leptospira interrogans, are highly specific for 2,3-diamino-2,3-dideoxy-D-glucopyranose, while others, such as the enzyme from Acidithiobacillus ferrooxidans, are also able to accept UDP-N-acetyl-alpha-D-glucosamine (cf. EC 2.3.1.129).
  • The enzymes from different organisms also differ in their specificity for the acyl donor. The enzyme from L. interrogans is highly specific for (3R)-3-hydroxydodecanoyl-[acyl-carrier protein], while that from Mesorhizobium loti functions almost equally well with 10-, 12-, and 14-carbon 3-hydroxyacyl-[acyl-carrier protein]s.
Cross-references
BRENDA2.3.1.305
EC2PDB2.3.1.305
ExplorEnz2.3.1.305
KEGG Ligand Database for Enzyme Nomenclature2.3.1.305
IUBMB Enzyme Nomenclature2.3.1.305
MEDLINEFind literature relating to 2.3.1.305
MetaCyc2.3.1.305
Rhea expert-curated reactions2.3.1.305

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-