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ENZYME

ENZYME entry: EC 2.3.1.37

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.37
Accepted Name
5-aminolevulinate synthase
Alternative Name(s)
5-aminolevulinic acid synthase
ALAS
delta-ALA synthetase
delta-aminolevulinate synthase
Reaction catalysed
succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA
Comment(s)
  • A pyridoxal 5'-phosphate protein.
  • The enzyme, which catalyzes the first reaction of a tetrapyrrole biosynthesis pathway, is found in alphaproteobacteria and most eukaryotes, except plants.
  • A genetically distinct form (ALAS2) is found in erythrocytes.
  • The enzyme is also found in some bacteriophages from aquatic environments.
Cross-references
BRENDA2.3.1.37
EC2PDB2.3.1.37
ExplorEnz2.3.1.37
KEGG Ligand Database for Enzyme Nomenclature2.3.1.37
IUBMB Enzyme Nomenclature2.3.1.37
MEDLINEFind literature relating to 2.3.1.37
MetaCyc2.3.1.37
Rhea expert-curated reactions2.3.1.37
UniProtKB/Swiss-Prot
Q3ZC31, HEM0_BOVINQ06965, HEM0_CERS4P18080, HEM0_CHICK
Q9YHT4, HEM0_DANREQ9XT75, HEM0_DELLEP22557, HEM0_HUMAN
P08680, HEM0_MOUSEP43090, HEM0_OPSTAQ5R557, HEM0_PONAB
Q63147, HEM0_RATQ92403, HEM1_AGABIP26505, HEM1_AGRRD
A6QLI6, HEM1_BOVINP08262, HEM1_BRADUO94069, HEM1_CANAL
Q6FXE3, HEM1_CANGAQ04512, HEM1_CERS4P07997, HEM1_CHICK
Q6BX71, HEM1_DEBHAQ9XS79, HEM1_DELLEP38092, HEM1_EMENI
Q75DX7, HEM1_EREGSP13196, HEM1_HUMANP78698, HEM1_KLULA
Q8VC19, HEM1_MOUSEQ7RVY5, HEM1_NEUCRP43091, HEM1_OPSTA
P43089, HEM1_PARDPQ5R9R9, HEM1_PONABP13195, HEM1_RAT
P08080, HEM1_RHIMEP18079, HEM1_RHOCBQ1RIV2, HEM1_RICBR
Q92G23, HEM1_RICCNQ4UJV4, HEM1_RICFEQ9ZCB8, HEM1_RICPR
Q68VS3, HEM1_RICTYO14092, HEM1_SCHPOQ6CCW0, HEM1_YARLI
P09950, HEM1_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-