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ENZYME

ENZYME entry: EC 2.3.1.39

Accepted Name
[acyl-carrier-protein] S-malonyltransferase
Alternative Name(s)
acyl carrier protein malonyltransferase
malonyl-CoA/dephospho-CoA acyltransferase
malonyl-CoA-acyl carrier protein transacylase
malonyl coenzyme A-acyl carrier protein transacylase
malonyl transacylase
malonyl transferase
MCAT
Reaction catalysed
holo-[ACP] + malonyl-CoA <=> CoA + malonyl-[ACP]
Comment(s)
  • Essential, along with EC 2.3.1.38, for the initiation of fatty-acid biosynthesis in bacteria.
  • Also provides the malonyl groups for polyketide biosynthesis.
  • The product of the reaction, malonyl-ACP, is an elongation substrate in fatty-acid biosynthesis.
  • In Mycobacterium tuberculosis, holo-ACP (the product of EC 2.7.8.7) is the preferred substrate.
  • This enzyme also forms part of the multienzyme complexes EC 4.1.1.88 and EC 4.1.1.89.
  • Malonylation of ACP is immediately followed by decarboxylation within the malonate-decarboxylase complex to yield acetyl-ACP, the catalytically active species of the decarboxylase.
  • In the enzyme from Klebsiella pneumoniae, methylmalonyl-CoA can also act as a substrate but acetyl-CoA cannot whereas the enzyme from Pseudomonas putida can use both as substrates.
  • The ACP subunit found in fatty-acid biosynthesis contains a pantetheine-4'-phosphate cofactor; that from malonate decarboxylase also contains pantetheine-4'-phosphate but in the form of a 2'-(5-triphosphoribosyl)-3'-dephospho-CoA cofactor.
Cross-references
BRENDA2.3.1.39
EC2PDB2.3.1.39
ExplorEnz2.3.1.39
PRIAM enzyme-specific profiles2.3.1.39
KEGG Ligand Database for Enzyme Nomenclature2.3.1.39
IUBMB Enzyme Nomenclature2.3.1.39
IntEnz2.3.1.39
MEDLINEFind literature relating to 2.3.1.39
MetaCyc2.3.1.39
Rhea expert-curated reactions2.3.1.39
UniProtKB/Swiss-Prot
Q8TGA1, AFLB_ASPPUQ5AV07, ATNM_EMENIA7Z4X8, BAEC_BACVZ
A7Z4Y0, BAEE_BACVZP71019, FABD_BACSUQ8K9J6, FABD_BUCAP
Q89AH0, FABD_BUCBPQ8T3L6, FABD_DROMEQ8X8I7, FABD_ECO57
P0AAJ0, FABD_ECOL6P0AAI9, FABD_ECOLIP43712, FABD_HAEIN
Q8IVS2, FABD_HUMANQ8R3F5, FABD_MOUSEP63459, FABD_MYCBO
A0R0B2, FABD_MYCS2P9WNG4, FABD_MYCTOP9WNG5, FABD_MYCTU
O85140, FABD_SALTYO13698, FABD_SCHPOQ5HGK3, FABD_STAAC
Q99UN8, FABD_STAAMQ7A5Z3, FABD_STAANQ6GHK5, FABD_STAAR
Q6G9Y3, FABD_STAASQ93QD4, FABD_STAAUQ7A124, FABD_STAAW
P73242, FABD_SYNY3Q12283, FABD_YEASTP34731, FAS1_CANAX
Q9UUG0, FAS1_SCHPOP34229, FAS1_YARLIP07149, FAS1_YEAST
Q71SP7, FAS_BOVINP12276, FAS_CHICKP49327, FAS_HUMAN
P19096, FAS_MOUSEP12785, FAS_RATQ9R9J2, FENF_BACIU
I1S489, GRA7_GIBZEM2XHU6, HEXB_DOTSNQ2TXG3, ORYB_ASPOR
A0A1U8QK63, PKIC_EMENIO34825, PKSC_BACSUO34787, PKSE_BACSU
Q00706, STCK_EMENIQ2T4N0, THAF_BURTAQ92215, TOXC_COCCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-