A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 4.1.1.89
| Accepted Name |
|---|
| Biotin-dependent malonate decarboxylase.
|
| Alternative Name(s) |
|---|
| Malonate carboxy-lyase (biotin-dependent). |
| Malonate decarboxylase. |
| Reaction catalysed |
|---|
| Malonate + H(+) <=> acetate + CO(2) |
| Comment(s) |
|---|
- Two types of malonate decarboxylase are currently known, both of
which form multienzyme complexes.
- The enzyme described here is a biotin-dependent, Na(+)-translocating
enzyme that includes both soluble and membrane-bound components.
- The other type is a biotin-independent cytosolic protein (cf.
EC 4.1.1.88).
- As free malonate is chemically rather inert, it has to be activated
prior to decarboxylation.
- Both enzymes achieve this by exchanging malonate with an acetyl group
bound to an acyl-carrier protiein (ACP), to form malonyl-ACP and
acetate, with subsequent decarboxylation regenerating the acetyl-
bound form of the enzyme.
- The ACP subunit of both enzymes differs from that found in fatty-acid
biosynthesis by having phosphopantethine attached to a serine side-
chain as 2'-(5-triphosphoribosyl)-3'-dephospho-CoA rather than as
phosphopantetheine 4'-phosphate.
- In the anaerobic bacterium Malonomonas rubra, the components of the
multienzyme complex/enzymes involved in carrying out the reactions of
this enzyme are as follows: MadA (EC 2.3.1.187), MadB (EC 4.3.99.2),
MadC/MadD (EC 2.1.3.10) and MadH (EC 6.2.1.35).
- Two other components that are involved are MadE, the acyl-carrier
protein and MadF, the biotin protein.
- The carboxy group is lost with retention of configuration.
|
| Cross-references |
|---|
| PROSITE | PDOC50980 |
| BRENDA | 4.1.1.89 |
| EC2PDB | 4.1.1.89 |
| ExplorEnz | 4.1.1.89 |
| PRIAM enzyme-specific profiles | 4.1.1.89 |
| KEGG Ligand Database for Enzyme Nomenclature | 4.1.1.89 |
| IUBMB Enzyme Nomenclature | 4.1.1.89 |
| IntEnz | 4.1.1.89 |
| MEDLINE | Find literature relating to 4.1.1.89 |
| MetaCyc | 4.1.1.89 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-