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ENZYME entry: EC 2.3.1.43

Accepted Name
Phosphatidylcholine--sterol O-acyltransferase.
Alternative Name(s)
LCAT.
Lecithin--cholesterol acyltransferase.
Phospholipid--cholesterol acyltransferase.
Reaction catalysed
Phosphatidylcholine + a sterol <=> 1-acylglycerophosphocholine + a sterol ester
Comment(s)
  • Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors.
  • The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.
Cross-references
PROSITEPDOC00110
BRENDA2.3.1.43
EC2PDB2.3.1.43
ExplorEnz2.3.1.43
PRIAM enzyme-specific profiles2.3.1.43
KEGG Ligand Database for Enzyme Nomenclature2.3.1.43
IUBMB Enzyme Nomenclature2.3.1.43
IntEnz2.3.1.43
MEDLINEFind literature relating to 2.3.1.43
MetaCyc2.3.1.43
Rhea expert-curated reactions2.3.1.43
UniProtKB/Swiss-Prot
P10480, GCAT_AERHY;  P53760, LCAT_CHICK;  O35573, LCAT_ELIQU;  
O35840, LCAT_GERGM;  P04180, LCAT_HUMAN;  O35724, LCAT_MICMN;  
P16301, LCAT_MOUSE;  O35502, LCAT_MYOGA;  Q08758, LCAT_PAPAN;  
P30930, LCAT_PIG;  P53761, LCAT_RABIT;  P18424, LCAT_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
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