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ENZYME

ENZYME entry: EC 2.3.1.43

PURL: https://purl.expasy.org/enzyme/EC/2.3.1.43
Accepted Name
phosphatidylcholine--sterol O-acyltransferase
Alternative Name(s)
LCAT
lecithin--cholesterol acyltransferase
phospholipid--cholesterol acyltransferase
Reaction catalysed
a sterol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a sterol ester + a 1-acyl-sn-glycero-3-phosphocholine
Comment(s)
  • Palmitoyl, oleoyl, and linoleoyl can be transferred; a number of sterols, including cholesterol, can act as acceptors.
  • The bacterial enzyme also catalyzes the reactions of EC 3.1.1.4 and EC 3.1.1.5.
Cross-references
BRENDA2.3.1.43
EC2PDB2.3.1.43
ExplorEnz2.3.1.43
KEGG Ligand Database for Enzyme Nomenclature2.3.1.43
IUBMB Enzyme Nomenclature2.3.1.43
MEDLINEFind literature relating to 2.3.1.43
MetaCyc2.3.1.43
Rhea expert-curated reactions2.3.1.43
UniProtKB/Swiss-Prot
P10480, GCAT_AERHYP53760, LCAT_CHICKO35573, LCAT_ELIQU
O35840, LCAT_GERGMP04180, LCAT_HUMANO35724, LCAT_MICMN
P16301, LCAT_MOUSEO35502, LCAT_MYOGAQ08758, LCAT_PAPAN
P30930, LCAT_PIGP53761, LCAT_RABITP18424, LCAT_RAT

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-