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ENZYME entry: EC 2.3.1.9

Accepted Name
Acetyl-CoA C-acetyltransferase.
Alternative Name(s)
Acetoacetyl-CoA thiolase.
Reaction catalysed
2 acetyl-CoA <=> CoA + acetoacetyl-CoA
Comment(s)
  • The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms.
  • The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA.
  • In the second step the acyl group is transferred to an acetyl-CoA molecule.
  • Cf. EC 2.3.1.16.
Cross-references
PROSITEPDOC00092
BRENDA2.3.1.9
EC2PDB2.3.1.9
ExplorEnz2.3.1.9
PRIAM enzyme-specific profiles2.3.1.9
KEGG Ligand Database for Enzyme Nomenclature2.3.1.9
IUBMB Enzyme Nomenclature2.3.1.9
IntEnz2.3.1.9
MEDLINEFind literature relating to 2.3.1.9
MetaCyc2.3.1.9
Rhea expert-curated reactions2.3.1.9
UniProtKB/Swiss-Prot
P76461, ATOB_ECOLI;  P44873, ATOB_HAEIN;  Q9I2A8, ATOB_PSEAE;  
Q0KBP1, BKTB_CUPNH;  B0XMC1, ER10A_ASPFC;  Q4WLA8, ER10A_ASPFU;  
I1RMA2, ER10A_GIBZE;  B0YA65, ER10B_ASPFC;  Q4WCL5, ER10B_ASPFU;  
I1RY81, ER10B_GIBZE;  A0A1D8PH52, ERG10_CANAL;  P10551, ERG10_SACMO;  
Q9UQW6, ERG10_SCHPO;  P41338, ERG10_YEAST;  P66927, FADA4_MYCBO;  
P46707, FADA4_MYCLE;  A0R1Y7, FADA4_MYCS2;  P9WG68, FADA4_MYCTO;  
P9WG69, FADA4_MYCTU;  Q12598, THIA_CANTR;  Q04677, THIB_CANTR;  
Q8S4Y1, THIC1_ARATH;  Q9FIK7, THIC2_ARATH;  Q9BWD1, THIC_HUMAN;  
Q8CAY6, THIC_MOUSE;  Q5XI22, THIC_RAT;  Q921H8, THIKA_MOUSE;  
P21775, THIKA_RAT;  Q8VCH0, THIKB_MOUSE;  P07871, THIKB_RAT;  
P09110, THIK_HUMAN;  Q86AD9, THIL1_DICDI;  Q6NU46, THILA_XENLA;  
Q6GN02, THILB_XENLA;  P45369, THIL_ALLVD;  Q29RZ0, THIL_BOVIN;  
Q9ZHI1, THIL_CHRVO;  P14611, THIL_CUPNH;  Q6AZA0, THIL_DANRE;  
P24752, THIL_HUMAN;  Q8HXY6, THIL_MACFA;  Q8QZT1, THIL_MOUSE;  
P54810, THIL_PARDE;  P14610, THIL_PIG;  P17764, THIL_RAT;  
P50174, THIL_RHIME;  P73825, THIL_SYNY3;  P45363, THIL_THIVI;  
Q5BKN8, THIL_XENTR;  Q6L8K7, THIL_YARLI;  P07097, THIL_ZOORA;  
Q3T0R7, THIM_BOVIN;  P42765, THIM_HUMAN;  Q8BWT1, THIM_MOUSE;  
Q5RES5, THIM_PONAB;  P13437, THIM_RAT;  P45359, THLA_CLOAB;  
Q18AR0, THLA_CLOD6;  Q2FJQ9, THLA_STAA3;  Q2G124, THLA_STAA8;  
Q2YVF5, THLA_STAAB;  Q5HIU0, THLA_STAAC;  Q99WM3, THLA_STAAM;  
Q7A7L2, THLA_STAAN;  Q6GJW4, THLA_STAAR;  Q6GCB8, THLA_STAAS;  
Q8NY95, THLA_STAAW;  Q5HS07, THLA_STAEQ;  Q8CQN7, THLA_STAES;  
Q0AVM3, THLA_SYNWW;  P45855, THL_BACSU;  P45362, THL_CLODI;  
P81347, THL_CLOPA;  Q46939, YQEF_ECOLI;  

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