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ENZYME

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ENZYME entry: EC 2.3.1.9

Accepted Name
acetyl-CoA C-acetyltransferase
Alternative Name(s)
acetoacetyl-CoA thiolase
Reaction catalysed
2 acetyl-CoA = acetoacetyl-CoA + CoA
Comment(s)
  • The enzyme, found in both eukaryotes and prokaryotes, catalyzes the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms.
  • The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA.
  • In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16.
Cross-references
BRENDA2.3.1.9
EC2PDB2.3.1.9
ExplorEnz2.3.1.9
PRIAM enzyme-specific profiles2.3.1.9
KEGG Ligand Database for Enzyme Nomenclature2.3.1.9
IUBMB Enzyme Nomenclature2.3.1.9
IntEnz2.3.1.9
MEDLINEFind literature relating to 2.3.1.9
MetaCyc2.3.1.9
Rhea expert-curated reactions2.3.1.9
UniProtKB/Swiss-Prot
Q9FIK7, AACT1_ARATHQ8S4Y1, ACCT2_ARATHP76461, ATOB_ECOLI
P44873, ATOB_HAEINQ9I2A8, ATOB_PSEAEQ0KBP1, BKTB_CUPNH
B0XMC1, ER10A_ASPFCQ4WLA8, ER10A_ASPFUI1RMA2, ER10A_GIBZE
B0YA65, ER10B_ASPFCQ4WCL5, ER10B_ASPFUI1RY81, ER10B_GIBZE
A0A1D8PH52, ERG10_CANALP10551, ERG10_SACMOQ9UQW6, ERG10_SCHPO
P41338, ERG10_YEASTP66927, FADA4_MYCBOP46707, FADA4_MYCLE
A0R1Y7, FADA4_MYCS2P9WG68, FADA4_MYCTOP9WG69, FADA4_MYCTU
Q12598, THIA_CANTRQ04677, THIB_CANTRQ9BWD1, THIC_HUMAN
Q8CAY6, THIC_MOUSEQ5XI22, THIC_RATQ921H8, THIKA_MOUSE
P21775, THIKA_RATQ8VCH0, THIKB_MOUSEP07871, THIKB_RAT
P09110, THIK_HUMANQ86AD9, THIL1_DICDIQ6NU46, THILA_XENLA
Q6GN02, THILB_XENLAP45369, THIL_ALLVDQ29RZ0, THIL_BOVIN
Q9ZHI1, THIL_CHRVOP14611, THIL_CUPNHQ6AZA0, THIL_DANRE
P24752, THIL_HUMANQ8HXY6, THIL_MACFAQ8QZT1, THIL_MOUSE
P54810, THIL_PARDEP14610, THIL_PIGP17764, THIL_RAT
P50174, THIL_RHIMEP07097, THIL_SHIZOP73825, THIL_SYNY3
P45363, THIL_THIVIQ5BKN8, THIL_XENTRQ6L8K7, THIL_YARLI
Q3T0R7, THIM_BOVINP42765, THIM_HUMANQ8BWT1, THIM_MOUSE
Q5RES5, THIM_PONABP13437, THIM_RATP45359, THLA_CLOAB
Q18AR0, THLA_CLOD6P45362, THLA_CLODIP81347, THLA_CLOPA
Q2FJQ9, THLA_STAA3Q2G124, THLA_STAA8Q2YVF5, THLA_STAAB
Q5HIU0, THLA_STAACQ99WM3, THLA_STAAMQ7A7L2, THLA_STAAN
Q6GJW4, THLA_STAARQ6GCB8, THLA_STAASQ8NY95, THLA_STAAW
Q5HS07, THLA_STAEQQ8CQN7, THLA_STAESQ0AVM3, THLA_SYNWW
P45855, THL_BACSUQ46939, YQEF_ECOLI

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-