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ENZYME

ENZYME entry: EC 2.3.1.16

Accepted Name
acetyl-CoA C-acyltransferase
Alternative Name(s)
3-ketoacyl-CoA thiolase
beta-ketothiolase
Reaction catalysed
acetyl-CoA + an acyl-CoA <=> a 3-oxoacyl-CoA + CoA
Comment(s)
  • The enzyme, found in both eukaryotes and in prokaryotes, is involved in degradation pathways such as fatty acid beta-oxidation.
  • The enzyme acts on 3-oxoacyl-CoAs to produce acetyl-CoA and an acyl- CoA shortened by two carbon atoms.
  • The reaction starts with the acylation of a nucleophilic cysteine at the active site by a 3-oxoacyl-CoA, with the concomitant release of acetyl-CoA.
  • In the second step the acyl group is transferred to CoA.
  • Most enzymes have a broad substrate range for the 3-oxoacyl-CoA. cf. EC 2.3.1.9.
Cross-references
BRENDA2.3.1.16
EC2PDB2.3.1.16
ExplorEnz2.3.1.16
PRIAM enzyme-specific profiles2.3.1.16
KEGG Ligand Database for Enzyme Nomenclature2.3.1.16
IUBMB Enzyme Nomenclature2.3.1.16
IntEnz2.3.1.16
MEDLINEFind literature relating to 2.3.1.16
MetaCyc2.3.1.16
Rhea expert-curated reactions2.3.1.16
UniProtKB/Swiss-Prot
Q0KBP1, BKTB_CUPNHO46629, ECHB_BOVINP55084, ECHB_HUMAN
Q8HXX4, ECHB_MACFAQ99JY0, ECHB_MOUSEQ5R1W7, ECHB_PANTR
Q60587, ECHB_RATP34255, ECHH_CAEELI6XHI4, FADA5_MYCTU
I6XHJ3, FADA6_MYCTUQ6FF69, FADA_ACIADB7H1I1, FADA_ACIB3
B7I3P0, FADA_ACIB5B2I2J8, FADA_ACIBCB0VLX5, FADA_ACIBS
A3M1H9, FADA_ACIBTB0VE46, FADA_ACIBYA0KEL0, FADA_AERHH
A4STF3, FADA_AERS4Q0VNZ7, FADA_ALCBSQ5E8X7, FADA_ALIF1
B5FEW7, FADA_ALIFMB6EGU1, FADA_ALISLO32177, FADA_BACSU
Q1QUW9, FADA_CHRSDA8ACZ3, FADA_CITK8Q489W4, FADA_COLP3
A7MQM5, FADA_CROS8A7ZU50, FADA_ECO24Q8X8J4, FADA_ECO57
A8A6V0, FADA_ECOHSA1AI32, FADA_ECOK1Q0TAL1, FADA_ECOL5
Q8FBI3, FADA_ECOL6P21151, FADA_ECOLIQ1R467, FADA_ECOUT
A4WFX5, FADA_ENT38Q9F0Y6, FADA_ENTCLB2VFE0, FADA_ERWT9
B7LTZ0, FADA_ESCF3Q2SD23, FADA_HAHCHQ5QXH8, FADA_IDILO
A6TGM3, FADA_KLEP7A6VVM8, FADA_MARMSA1TZR8, FADA_MARN8
Q6DAP6, FADA_PECASC6DI66, FADA_PECCPQ7MZ91, FADA_PHOLL
Q6LW07, FADA_PHOPRQ48GW4, FADA_PSE14Q15ZF4, FADA_PSEA6
A6V383, FADA_PSEA7Q02PH7, FADA_PSEABQ9HZJ3, FADA_PSEAE
Q1I7D5, FADA_PSEE4Q4KFC3, FADA_PSEF5P28790, FADA_PSEFR
A4XSM9, FADA_PSEMYQ93Q11, FADA_PSEOLA5W6G9, FADA_PSEP1
Q3K9D9, FADA_PSEPFQ88L01, FADA_PSEPKQ9R9W0, FADA_PSEPU
Q87ZB3, FADA_PSESMQ3IJ24, FADA_PSET1Q4ZRA1, FADA_PSEU2
A4VKA4, FADA_PSEU5Q4FQC7, FADA_PSYA2Q1Q8K0, FADA_PSYCK
A5WH98, FADA_PSYWFQ21KB1, FADA_SACD2Q57HM7, FADA_SALCH
Q5PKQ3, FADA_SALPAP0A2H8, FADA_SALTIP0A2H7, FADA_SALTY
A8G8D0, FADA_SERP5A1S1I7, FADA_SHEAMA3CYJ3, FADA_SHEB5
A6WH99, FADA_SHEB8Q12TB5, FADA_SHEDOQ08A40, FADA_SHEFN
A3Q8U3, FADA_SHELPQ8EKS0, FADA_SHEONA4Y1B5, FADA_SHEPC
A0KR49, FADA_SHESAQ0HPB8, FADA_SHESMQ0I0T4, FADA_SHESR
A1RDW3, FADA_SHESWQ31UE3, FADA_SHIBSQ32A20, FADA_SHIDS
Q0SZ35, FADA_SHIF8Q83PG2, FADA_SHIFLQ3YVC2, FADA_SHISS
A5F464, FADA_VIBC3Q9KNI0, FADA_VIBCHQ87TP0, FADA_VIBPA
Q8DDK5, FADA_VIBVUQ7MQI0, FADA_VIBVYA1JIG3, FADA_YERE8
A7FDF1, FADA_YERP3Q1C2C3, FADA_YERPAQ8ZAM9, FADA_YERPE
Q1CNA0, FADA_YERPNA4TR28, FADA_YERPPQ66FR9, FADA_YERPS
A0KK76, FADI_AERHHA4SMT9, FADI_AERS4Q5E3U0, FADI_ALIF1
B5FGB5, FADI_ALIFMB4RTU9, FADI_ALTMDA8ADP1, FADI_CITK8
Q47ZB6, FADI_COLP3A7MH80, FADI_CROS8A7ZPF9, FADI_ECO24
B7UFZ9, FADI_ECO27B7MGV8, FADI_ECO45B7LBJ6, FADI_ECO55
Q8XCN9, FADI_ECO57B5YXY5, FADI_ECO5EB7NP25, FADI_ECO7I
B7MY17, FADI_ECO81B7M6M3, FADI_ECO8AC4ZVN3, FADI_ECOBW
B1X9L5, FADI_ECODHA8A2L1, FADI_ECOHSA1ADI9, FADI_ECOK1
Q0TFA5, FADI_ECOL5Q8FFG3, FADI_ECOL6B1IXA4, FADI_ECOLC
P76503, FADI_ECOLIB7N5V3, FADI_ECOLUB6I6Q5, FADI_ECOSE
B1LME8, FADI_ECOSMQ1R971, FADI_ECOUTA4WCW7, FADI_ENT38
B2VJ10, FADI_ERWT9B7LLC9, FADI_ESCF3Q5QXN5, FADI_IDILO
B5XVW1, FADI_KLEP3A6TC20, FADI_KLEP7Q6D2L6, FADI_PECAS
C6DAL8, FADI_PECCPQ7N287, FADI_PHOLLQ6LTK4, FADI_PHOPR
Q15VA3, FADI_PSEA6Q3IEE3, FADI_PSET1B5EZS0, FADI_SALA4
A9MJ36, FADI_SALARQ57LW5, FADI_SALCHB5FPN2, FADI_SALDC
B5R3S0, FADI_SALEPB4TCA9, FADI_SALHSB4SZR1, FADI_SALNS
Q5PCX7, FADI_SALPAA9N452, FADI_SALPBC0PZX5, FADI_SALPC
B5BBA0, FADI_SALPKB4TQC3, FADI_SALSVQ8Z4Y9, FADI_SALTI
Q8ZNA6, FADI_SALTYA8GH87, FADI_SERP5A1S7L7, FADI_SHEAM
B8EE97, FADI_SHEB2A3D685, FADI_SHEB5A6WQ26, FADI_SHEB8
A9KTW7, FADI_SHEB9Q12P12, FADI_SHEDOQ07ZP7, FADI_SHEFN
B0TL22, FADI_SHEHHA3QFP4, FADI_SHELPQ8ECP6, FADI_SHEON
A8H5T2, FADI_SHEPAA4Y898, FADI_SHEPCB8CPY7, FADI_SHEPW
A0KV75, FADI_SHESAA8FTR6, FADI_SHESHQ0HKD2, FADI_SHESM
Q0HWN4, FADI_SHESRA1RI91, FADI_SHESWB1KKT1, FADI_SHEWM
B2TWV5, FADI_SHIB3Q31YB6, FADI_SHIBSQ32DJ3, FADI_SHIDS
Q0T2E5, FADI_SHIF8Q83K95, FADI_SHIFLQ3YZM1, FADI_SHISS
A5F2P1, FADI_VIBC3Q9KT59, FADI_VIBCHQ87MM2, FADI_VIBPA
Q8DB48, FADI_VIBVUQ7MIS4, FADI_VIBVYA1JK23, FADI_YERE8
A7FGK0, FADI_YERP3Q1C659, FADI_YERPAB2K8J6, FADI_YERPB
Q8ZD46, FADI_YERPEA9R7W9, FADI_YERPGQ1CHK1, FADI_YERPN
A4TM83, FADI_YERPPQ668V0, FADI_YERPSB1JGG1, FADI_YERPY
C8YNG6, KAT1_PETHYP07857, SCP2_BOVINQ07598, SCP2_CHICK
P22307, SCP2_HUMANP32020, SCP2_MOUSEO62742, SCP2_RABIT
P11915, SCP2_RATQ8LF48, THIK1_ARATHQ56WD9, THIK2_ARATH
Q570C8, THIK5_ARATHP33290, THIKA_CANTRQ921H8, THIKA_MOUSE
P21775, THIKA_RATP33291, THIKB_CANTRQ8VCH0, THIKB_MOUSE
P07871, THIKB_RATQ8SVA6, THIK_ENCCUP09110, THIK_HUMAN
Q05493, THIK_YARLIP27796, THIK_YEASTQ3T0R7, THIM_BOVIN
P42765, THIM_HUMANQ8BWT1, THIM_MOUSEQ5RES5, THIM_PONAB
P13437, THIM_RAT

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-