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ENZYME

ENZYME entry: EC 2.3.2.16

PURL: https://purl.expasy.org/enzyme/EC/2.3.2.16
Accepted Name
lipid II:glycine glycyltransferase
Reaction catalysed
beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + glycyl-tRNA(Gly) = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + tRNA(Gly) + H(+)
Comment(s)
  • This enzyme from Staphylococcus aureus catalyzes the transfer of glycine from a charged tRNA to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D- Ala-D-Ala-diphosphoundecaprenyl-GlcNAc (lipid II), attaching it to the N(6) of the L-lysine at position 3 of the pentapeptide.
  • This is the first step in the synthesis of the pentaglycine interpeptide bridge that is used in S.aureus for the cross-linking of different glycan strands to each other.
  • Four additional glycine residues are subsequently attached by EC 2.3.2.17 (FemA) and EC 2.3.2.18 (FemB).
Cross-references
BRENDA2.3.2.16
EC2PDB2.3.2.16
ExplorEnz2.3.2.16
KEGG Ligand Database for Enzyme Nomenclature2.3.2.16
IUBMB Enzyme Nomenclature2.3.2.16
MEDLINEFind literature relating to 2.3.2.16
MetaCyc2.3.2.16
Rhea expert-curated reactions2.3.2.16
UniProtKB/Swiss-Prot
Q2FEM9, FEMX_STAA3Q2FVZ4, FEMX_STAA8Q2YYN5, FEMX_STAAB
Q5HDU6, FEMX_STAACQ7A2M4, FEMX_STAAMQ7A447, FEMX_STAAN
Q6GEH2, FEMX_STAARQ6G760, FEMX_STAASP0C1Q0, FEMX_STAAU
Q8NVA9, FEMX_STAAWQ5HLY6, FEMX_STAEQQ8CNE9, FEMX_STAES
Q4L8C6, FEMX_STAHJQ49ZI0, FEMX_STAS1

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
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