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ENZYME

ENZYME entry: EC 2.3.2.17

Accepted Name
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D- alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase
Reaction catalysed
beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) = 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly)
Comment(s)
  • This enzyme catalyzes the successive transfer of two glycine moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)- D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching them to a glycine residue previously attached by EC 2.3.2.16 (FemX) to the N(6) of the L-lysine at position 3 of the pentapeptide.
  • This is the second step in the synthesis of the pentaglycine interpeptide bridge that is used by Staphylococcus aureus for the cross-linking of different glycan strands to each other.
  • The next step is catalyzed by EC 2.3.2.18 (FemB).
  • This enzyme is essential for methicillin resistance.
Cross-references
BRENDA2.3.2.17
EC2PDB2.3.2.17
ExplorEnz2.3.2.17
PRIAM enzyme-specific profiles2.3.2.17
KEGG Ligand Database for Enzyme Nomenclature2.3.2.17
IUBMB Enzyme Nomenclature2.3.2.17
IntEnz2.3.2.17
MEDLINEFind literature relating to 2.3.2.17
MetaCyc2.3.2.17
Rhea expert-curated reactions2.3.2.17
UniProtKB/Swiss-Prot
Q2FYR2, FEMA_STAA8Q2YXZ5, FEMA_STAABQ5HG45, FEMA_STAAC
Q99UA7, FEMA_STAAMQ7A5R3, FEMA_STAANQ6GH31, FEMA_STAAR
Q6G9I5, FEMA_STAASP0A0A5, FEMA_STAAUP0A0A4, FEMA_STAAW
P95734, FEMA_STAEPQ5HPG6, FEMA_STAEQQ8CPA9, FEMA_STAES

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