ENZYME entry: EC 2.3.2.17
| Accepted Name |
|---|
| N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-
alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine
glycyltransferase.
|
| Reaction catalysed |
|---|
| beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + 2 glycyl-tRNA(Gly) <=> 2 H(+) + MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-di-trans,octa-cis-undecaprenyl-GlcNAc + 2 tRNA(Gly) |
| Comment(s) |
|---|
- This enzyme catalyzes the successive transfer of two glycine moieties
from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-
D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching
them to a glycine residue previously attached by EC 2.3.2.16 (FemX)
to the N(6) of the L-lysine at position 3 of the pentapeptide.
- This is the second step in the synthesis of the pentaglycine
interpeptide bridge that is used by Staphylococcus aureus for the
cross-linking of different glycan strands to each other.
- The next step is catalyzed by EC 2.3.2.18 (FemB).
- This enzyme is essential for methicillin resistance.
|
| Cross-references |
|---|
| BRENDA | 2.3.2.17 |
| EC2PDB | 2.3.2.17 |
| ExplorEnz | 2.3.2.17 |
| PRIAM enzyme-specific profiles | 2.3.2.17 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.3.2.17 |
| IUBMB Enzyme Nomenclature | 2.3.2.17 |
| IntEnz | 2.3.2.17 |
| MEDLINE | Find literature relating to 2.3.2.17 |
| MetaCyc | 2.3.2.17 |
| Rhea expert-curated reactions | 2.3.2.17 |
| UniProtKB/Swiss-Prot |
| Q2FYR2, FEMA_STAA8; | Q2YXZ5, FEMA_STAAB; | Q5HG45, FEMA_STAAC; |
| Q99UA7, FEMA_STAAM; | Q7A5R3, FEMA_STAAN; | Q6GH31, FEMA_STAAR; |
| Q6G9I5, FEMA_STAAS; | P0A0A5, FEMA_STAAU; | P0A0A4, FEMA_STAAW; |
| P95734, FEMA_STAEP; | Q5HPG6, FEMA_STAEQ; | Q8CPA9, FEMA_STAES; |
|
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