ENZYME entry: EC 2.3.2.17
Accepted Name |
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D-
alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine
glycyltransferase.
|
Reaction catalysed |
MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 glycyl-tRNA <=> MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 tRNA |
Comment(s) |
- This enzyme catalyzes the successive transfer of two glycine moieties
from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-
D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching
them to a glycine residue previously attached by EC 2.3.2.16 (FemX)
to the N(6) of the L-lysine at position 3 of the pentapeptide.
- This is the second step in the synthesis of the pentaglycine
interpeptide bridge that is used by Staphylococcus aureus for the
crosslinking of different glycan strands to each other.
- The next step is catalyzed by EC 2.3.2.18 (FemB).
- This enzyme is essential for methicillin resistance.
|
Cross-references |
BRENDA | 2.3.2.17 |
EC2PDB | 2.3.2.17 |
ExplorEnz | 2.3.2.17 |
PRIAM enzyme-specific profiles | 2.3.2.17 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.2.17 |
IUBMB Enzyme Nomenclature | 2.3.2.17 |
IntEnz | 2.3.2.17 |
MEDLINE | Find literature relating to 2.3.2.17 |
MetaCyc | 2.3.2.17 |
Rhea expert-curated reactions | 2.3.2.17 |
UniProtKB/Swiss-Prot |
Q2FYR2, FEMA_STAA8; | Q2YXZ5, FEMA_STAAB; | Q5HG45, FEMA_STAAC; |
Q99UA7, FEMA_STAAM; | Q7A5R3, FEMA_STAAN; | Q6GH31, FEMA_STAAR; |
Q6G9I5, FEMA_STAAS; | P0A0A5, FEMA_STAAU; | P0A0A4, FEMA_STAAW; |
P95734, FEMA_STAEP; | Q5HPG6, FEMA_STAEQ; | Q8CPA9, FEMA_STAES; |
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