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ENZYME entry: EC 2.3.2.17

Accepted Name
N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-(N(6)-glycyl)-D-alanyl-D- alanine-diphosphoundecaprenyl-N-acetylglucosamine:glycine glycyltransferase.
Reaction catalysed
MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 glycyl-tRNA <=> MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-tri-Gly)-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc + 2 tRNA
Comment(s)
  • This enzyme catalyzes the successive transfer of two glycine moieties from charged tRNAs to MurNAc-L-Ala-D-isoglutaminyl-L-Lys-(N(6)-Gly)- D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenyl-GlcNAc, attaching them to a glycine residue previously attached by EC 2.3.2.16 (FemX) to the N(6) of the L-lysine at position 3 of the pentapeptide.
  • This is the second step in the synthesis of the pentaglycine interpeptide bridge that is used by Staphylococcus aureus for the crosslinking of different glycan strands to each other.
  • The next step is catalyzed by EC 2.3.2.18 (FemB).
  • This enzyme is essential for methicillin resistance.
Cross-references
BRENDA2.3.2.17
EC2PDB2.3.2.17
ExplorEnz2.3.2.17
PRIAM enzyme-specific profiles2.3.2.17
KEGG Ligand Database for Enzyme Nomenclature2.3.2.17
IUBMB Enzyme Nomenclature2.3.2.17
IntEnz2.3.2.17
MEDLINEFind literature relating to 2.3.2.17
MetaCyc2.3.2.17
Rhea expert-curated reactions2.3.2.17
UniProtKB/Swiss-Prot
Q2FYR2, FEMA_STAA8;  Q2YXZ5, FEMA_STAAB;  Q5HG45, FEMA_STAAC;  
Q99UA7, FEMA_STAAM;  Q7A5R3, FEMA_STAAN;  Q6GH31, FEMA_STAAR;  
Q6G9I5, FEMA_STAAS;  P0A0A5, FEMA_STAAU;  P0A0A4, FEMA_STAAW;  
P95734, FEMA_STAEP;  Q5HPG6, FEMA_STAEQ;  Q8CPA9, FEMA_STAES;  

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