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ENZYME

ENZYME entry: EC 2.3.2.2

PURL: https://purl.expasy.org/enzyme/EC/2.3.2.2
Accepted Name
gamma-glutamyltransferase
Alternative Name(s)
gamma-glutamyltranspeptidase
gamma-glutamyl transpeptidase
glutamyl transpeptidase
Reaction catalysed
an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]
Comment(s)
  • The mammlian enzyme is part of the cell antioxidant defense mechanism.
  • It initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracelular GSH levels.
  • The protein also has EC 3.4.19.13 activity.
  • The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide.
  • The N-terminal L-threonine of the C-terminal subunit functions as the active site for both the cleavage and the hydrolysis reactions.
Cross-references
BRENDA2.3.2.2
EC2PDB2.3.2.2
ExplorEnz2.3.2.2
KEGG Ligand Database for Enzyme Nomenclature2.3.2.2
IUBMB Enzyme Nomenclature2.3.2.2
MEDLINEFind literature relating to 2.3.2.2
MetaCyc2.3.2.2
Rhea expert-curated reactions2.3.2.2
UniProtKB/Swiss-Prot
Q05902, ECM38_YEASTQ8VYW6, GAGT1_ARATHQ680I5, GAGT2_ARATH
Q9M0G0, GAGT3_ARATHD4B387, GGT1_ARTBCP19440, GGT1_HUMAN
Q60928, GGT1_MOUSEP20735, GGT1_PIGP07314, GGT1_RAT
Q9US04, GGT1_SCHPOO14194, GGT2_SCHPOA6NGU5, GGT3_HUMAN
P36269, GGT5_HUMANQ9Z2A9, GGT5_MOUSEQ9QWE9, GGT5_RAT
A7YWM1, GGT6_BOVINQ6P531, GGT6_HUMANQ6PDE7, GGT6_MOUSE
Q6IE08, GGT6_RATQ0V8L2, GGT7_BOVINQ9UJ14, GGT7_HUMAN
Q99JP7, GGT7_MOUSEQ99MZ4, GGT7_RATP63186, GGT_BACNA
P54422, GGT_BACSUP18956, GGT_ECOLIQ9I406, GGT_PSEAE
P36267, GGT_PSEUAP74181, GGT_SYNY3P15557, PAC1_PSES3
Q05053, PAC1_PSESVB8NM71, USTH_ASPFNO05218, YWRD_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-