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ENZYME

ENZYME entry: EC 3.4.19.13

PURL: https://purl.expasy.org/enzyme/EC/3.4.19.13
Accepted Name
glutathione gamma-glutamate hydrolase
Alternative Name(s)
gamma-glutamyltranspeptidase
glutathionase
Reaction catalysed
  • glutathione + H2O = L-cysteinylglycine + L-glutamate
  • an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
Comment(s)
  • This is a bifunctional protein that also has the activity of EC 2.3.2.2.
  • The enzyme binds its substrate by forming an initial gamma-glutamyl- enzyme intermediate, releasing the L-cysteinylglycine part of the molecule.
  • The enzyme then reacts with either a water molecule or a different acceptor substrate (usually an L-amino acid or a dipeptide) to form L-glutamate or a product containing a new gamma-glutamyl isopeptide bond, respectively.
  • The enzyme acts on glutathione, glutathione-S-conjugates, and, at a lower level, on other substrates with an N-terminal L-gamma-glutamyl residue.
  • It plays a crucial part in the glutathione-mediated xenobiotic detoxification pathway.
  • The enzyme consists of two chains that are created by the proteolytic cleavage of a single precursor polypeptide.
Cross-references
BRENDA3.4.19.13
EC2PDB3.4.19.13
ExplorEnz3.4.19.13
KEGG Ligand Database for Enzyme Nomenclature3.4.19.13
IUBMB Enzyme Nomenclature3.4.19.13
MEDLINEFind literature relating to 3.4.19.13
MetaCyc3.4.19.13
Rhea expert-curated reactions3.4.19.13
UniProtKB/Swiss-Prot
Q05902, ECM38_YEASTQ8VYW6, GAGT1_ARATHQ680I5, GAGT2_ARATH
Q9M0G0, GAGT3_ARATHD4B387, GGT1_ARTBCP19440, GGT1_HUMAN
Q60928, GGT1_MOUSEP20735, GGT1_PIGP07314, GGT1_RAT
Q9US04, GGT1_SCHPOO14194, GGT2_SCHPOA6NGU5, GGT3_HUMAN
P36269, GGT5_HUMANQ9Z2A9, GGT5_MOUSEQ9QWE9, GGT5_RAT
A7YWM1, GGT6_BOVINQ6P531, GGT6_HUMANQ6PDE7, GGT6_MOUSE
Q6IE08, GGT6_RATQ0V8L2, GGT7_BOVINQ9UJ14, GGT7_HUMAN
Q99JP7, GGT7_MOUSEQ99MZ4, GGT7_RATP63186, GGT_BACNA
P54422, GGT_BACSUP18956, GGT_ECOLIQ9I406, GGT_PSEAE
P36267, GGT_PSEUAP74181, GGT_SYNY3P15557, PAC1_PSES3
Q05053, PAC1_PSESVB8NM71, USTH_ASPFNO05218, YWRD_BACSU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.19.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.4.-.-
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