| Accepted Name |
|---|
| glutathione gamma-glutamate hydrolase
|
| Alternative Name(s) |
|---|
| gamma-glutamyltranspeptidase |
| glutathionase |
| Reaction catalysed |
|---|
- glutathione + H2O = L-cysteinylglycine + L-glutamate
- an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate
|
| Comment(s) |
|---|
- This is a bifunctional protein that also has the activity of
EC 2.3.2.2.
- The enzyme binds its substrate by forming an initial gamma-glutamyl-
enzyme intermediate, releasing the L-cysteinylglycine part of the
molecule.
- The enzyme then reacts with either a water molecule or a different
acceptor substrate (usually an L-amino acid or a dipeptide) to form
L-glutamate or a product containing a new gamma-glutamyl isopeptide
bond, respectively.
- The enzyme acts on glutathione, glutathione-S-conjugates, and, at a
lower level, on other substrates with an N-terminal L-gamma-glutamyl
residue.
- It plays a crucial part in the glutathione-mediated xenobiotic
detoxification pathway.
- The enzyme consists of two chains that are created by the proteolytic
cleavage of a single precursor polypeptide.
|
| Cross-references |
|---|
| Rhea expert-curated reactions | 3.4.19.13 |
| ExplorEnz | 3.4.19.13 |
| IUBMB Enzyme Nomenclature | 3.4.19.13 |
| UniProtKB/Swiss-Prot |
| Q05902, ECM38_YEAST | Q8VYW6, GAGT1_ARATH | Q680I5, GAGT2_ARATH |
| Q9M0G0, GAGT3_ARATH | D4B387, GGT1_ARTBC | P19440, GGT1_HUMAN |
| Q60928, GGT1_MOUSE | P20735, GGT1_PIG | P07314, GGT1_RAT |
| Q9US04, GGT1_SCHPO | O14194, GGT2_SCHPO | A6NGU5, GGT3_HUMAN |
| P36269, GGT5_HUMAN | Q9Z2A9, GGT5_MOUSE | Q9QWE9, GGT5_RAT |
| A7YWM1, GGT6_BOVIN | Q6P531, GGT6_HUMAN | Q6PDE7, GGT6_MOUSE |
| Q6IE08, GGT6_RAT | Q0V8L2, GGT7_BOVIN | Q9UJ14, GGT7_HUMAN |
| Q99JP7, GGT7_MOUSE | Q99MZ4, GGT7_RAT | P63186, GGT_BACNA |
| P54422, GGT_BACSU | P18956, GGT_ECOLI | Q9I406, GGT_PSEAE |
| P36267, GGT_PSEUA | P74181, GGT_SYNY3 | P15557, PAC1_PSES3 |
| Q05053, PAC1_PSESV | B8NM71, USTH_ASPFN | O05218, YWRD_BACSU |
|
| BRENDA | 3.4.19.13 |
| MetaCyc | 3.4.19.13 |
| KEGG Ligand Database for Enzyme Nomenclature | 3.4.19.13 |
| EC2PDB | 3.4.19.13 |
| MEDLINE | Find literature relating to 3.4.19.13 |
