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ENZYME

ENZYME entry: EC 2.3.2.23

PURL: https://purl.expasy.org/enzyme/EC/2.3.2.23
Accepted Name
E2 ubiquitin-conjugating enzyme
Alternative Name(s)
ubiquitin-carrier-protein E2
ubiquitin-conjugating enzyme E2
Reaction catalysed
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Comment(s)
  • The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself.
  • In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
  • Formerly EC 6.3.2.19.
Cross-references
BRENDA2.3.2.23
EC2PDB2.3.2.23
ExplorEnz2.3.2.23
KEGG Ligand Database for Enzyme Nomenclature2.3.2.23
IUBMB Enzyme Nomenclature2.3.2.23
MEDLINEFind literature relating to 2.3.2.23
MetaCyc2.3.2.23
Rhea expert-curated reactions2.3.2.23
UniProtKB/Swiss-Prot
Q8LGF7, PEX4_ARATHI1RRW0, PEX4_GIBZEC4R826, PEX4_KOMPG
P49428, PEX4_PICPAQ6ZWY6, U2D2B_MOUSEP70711, U2D2B_RAT
Q9VM35, U2QL1_DROMEA1L167, U2QL1_HUMANA0PJN4, U2QL1_MOUSE
Q2TA10, UB2D1_BOVINP51668, UB2D1_HUMANP61080, UB2D1_MOUSE
D3ZDK2, UB2D1_RATQ1RMX2, UB2D2_BOVINP62837, UB2D2_HUMAN
P62838, UB2D2_MOUSEQ06AA9, UB2D2_PIGP62839, UB2D2_RAT
P62840, UB2D2_XENLAQ3ZCF7, UB2D3_BOVINP61077, UB2D3_HUMAN
Q4R5N4, UB2D3_MACFAP61079, UB2D3_MOUSEQ5R4V7, UB2D3_PONAB
P61078, UB2D3_RATQ9Y2X8, UB2D4_HUMANA5PKP9, UB2D4_XENLA
P51965, UB2E1_HUMANP52482, UB2E1_MOUSEQ96LR5, UB2E2_HUMAN
Q91W82, UB2E2_MOUSEQ2T9X7, UB2E3_BOVINQ969T4, UB2E3_HUMAN
P52483, UB2E3_MOUSEP62253, UB2G1_HUMANQ4R5Y8, UB2G1_MACFA
P62254, UB2G1_MOUSEP62255, UB2G1_RATQ17QG5, UB2G2_BOVIN
P60604, UB2G2_HUMANP60605, UB2G2_MOUSEQ5RF84, UB2G2_PONAB
Q9Y385, UB2J1_HUMANQ9JJZ4, UB2J1_MOUSEQ2TA03, UB2J2_BOVIN
Q54LP7, UB2J2_DICDIQ8N2K1, UB2J2_HUMANQ6P073, UB2J2_MOUSE
Q54AK6, UB2JL_DICDIQ3MHP1, UB2L3_BOVINP68036, UB2L3_HUMAN
P68037, UB2L3_MOUSEQ5R5I4, UB2L3_PONABA0A1B0GUS4, UB2L5_HUMAN
A5PJC4, UB2L6_BOVINO14933, UB2L6_HUMANQ9QZU9, UB2L6_MOUSE
Q4V8J2, UB2L6_RATQ7Z7E8, UB2Q1_HUMANQ7TSS2, UB2Q1_MOUSE
Q32L27, UB2Q2_BOVINQ8WVN8, UB2Q2_HUMANQ8K2Z8, UB2Q2_MOUSE
Q7YQJ9, UB2Q2_RABITP49427, UB2R1_HUMANQ8CFI2, UB2R1_MOUSE
Q712K3, UB2R2_HUMANQ6ZWZ2, UB2R2_MOUSEQ29503, UB2R2_RABIT
A1L3K1, UB2SA_XENLAQ8AVU2, UB2SB_XENLAQ76EZ2, UB2SC_XENLA
Q4VBH4, UB2WA_DANREQ1JPX4, UB2WB_DANREP35133, UBC10_ARATH
Q7K738, UBC10_DROMEP35134, UBC11_ARATHO00103, UBC11_SCHPO
P52492, UBC11_YEASTQ9C9Y7, UBC12_ARATHQ42541, UBC13_ARATH
Q95XX0, UBC13_CAEELO13685, UBC13_SCHPOP52490, UBC13_YEAST
P42747, UBC14_ARATHQ9UTN8, UBC14_SCHPOP42743, UBC15_ARATH
Q9Y818, UBC15_SCHPOQ9FWT2, UBC16_ARATHQ9P6I1, UBC16_SCHPO
O23239, UBC17_ARATHQ9FMM0, UBC18_ARATHQ21633, UBC18_CAEEL
Q9LJZ5, UBC19_ARATHP25865, UBC1_ARATHP52478, UBC1_CAEEL
O74196, UBC1_COLGLQ5UQC9, UBC1_MIMIVQ9UVR2, UBC1_PYRO7
O74810, UBC1_SCHPOP21734, UBC1_YEASTQ8L7T3, UBC20_ARATH
P52484, UBC21_CAEELQ9FF66, UBC22_ARATHQ9ZVX1, UBC23_ARATH
Q8VY10, UBC24_ARATHQ9LUQ5, UBC25_ARATHQ93571, UBC25_CAEEL
Q8GY87, UBC26_ARATHQ9FI61, UBC27_ARATHQ94F47, UBC28_ARATH
Q9SLE4, UBC29_ARATHP42745, UBC2_ARATHQ4WLA7, UBC2_ASPFU
P35129, UBC2_CAEELO74201, UBC2_CANALQ6FR76, UBC2_CANGA
P0CS17, UBC2_CRYNBP0CS16, UBC2_CRYNJQ6BU36, UBC2_DEBHA
Q553F3, UBC2_DICDIQ96UP5, UBC2_EMENIQ75EB8, UBC2_EREGS
P78717, UBC2_FUSSLQ6CUD9, UBC2_KLULAP35130, UBC2_MEDSA
Q5UQ57, UBC2_MIMIVQ4PFA5, UBC2_MYCMDP52493, UBC2_NEUCR
P23566, UBC2_SCHPOQ58FS2, UBC2_TRIHAP25866, UBC2_WHEAT
Q6C093, UBC2_YARLIP06104, UBC2_YEASTQ9FKT3, UBC30_ARATH
Q9C8X7, UBC31_ARATHQ9LSP7, UBC32_ARATHQ9FK29, UBC33_ARATH
Q9SHI7, UBC34_ARATHQ94A97, UBC35_ARATHQ9FZ48, UBC36_ARATH
Q941B6, UBC37_ARATHQ9C918, UBC38_ARATHF4HPP7, UBC39_ARATH
P42746, UBC3_ARATHQ5UQ88, UBC3_MIMIVP14682, UBC3_YEAST
P42748, UBC4_ARATHP43102, UBC4_CANAXQ5UQ40, UBC4_MIMIV
P46595, UBC4_SCHPOP35135, UBC4_SOLLCP16577, UBC4_WHEAT
P15731, UBC4_YEASTQ8S920, UBC5A_ORYSJQ8S919, UBC5B_ORYSJ
P42749, UBC5_ARATHP15732, UBC5_YEASTP42750, UBC6_ARATH
Q6FQK7, UBC6_CANGAQ6BYG4, UBC6_DEBHAQ74Z34, UBC6_EREGS
Q6CMG6, UBC6_KLULAO42646, UBC6_SCHPOP33296, UBC6_YEAST
Q42540, UBC7_ARATHP34477, UBC7_CAEELO00102, UBC7_SCHPO
P25868, UBC7_WHEATQ02159, UBC7_YEASTP52487, UBC84_DROME
P35131, UBC8_ARATHQ9P7R4, UBC8_SCHPOP28263, UBC8_YEAST
Q94490, UBCB_DICDIP25867, UBCD1_DROMEP52485, UBCD2_DROME
P52486, UBCD4_DROMEP25153, UBCD6_DROMEQ86IZ3, UBCX_DICDI
O60015, UBCX_PICANP29340, UBCX_YEASTP27949, UBC_ASFB7
P0C8G3, UBC_ASFK5P25869, UBC_ASFM2P0C8G4, UBC_ASFP4
P0C8G5, UBC_ASFWAP49459, UBE2A_HUMANQ9Z255, UBE2A_MOUSE
Q32P99, UBE2B_BOVINP63146, UBE2B_HUMANP63147, UBE2B_MOUSE
P63148, UBE2B_RABITP63149, UBE2B_RATQ32PA5, UBE2C_BOVIN
Q54XS6, UBE2C_DICDIQ9VTY6, UBE2C_DROMEO00762, UBE2C_HUMAN
Q4R9D1, UBE2C_MACFAQ9D1C1, UBE2C_MOUSEQ95044, UBE2C_SPISO
P56616, UBE2C_XENLAQ32LN1, UBE2H_BOVINP62256, UBE2H_HUMAN
P62257, UBE2H_MOUSEP61085, UBE2K_BOVINP61086, UBE2K_HUMAN
P61087, UBE2K_MOUSEQ0P5K3, UBE2N_BOVINQ86K32, UBE2N_DICDI
P35128, UBE2N_DROMEP61088, UBE2N_HUMANQ4R4I1, UBE2N_MACFA
P61089, UBE2N_MOUSEQ5R7J6, UBE2N_PONABQ9EQX9, UBE2N_RAT
C1C3R6, UBE2S_AQUCTQ1RML1, UBE2S_BOVINC3Z724, UBE2S_BRAFL
Q4V908, UBE2S_DANREQ54I43, UBE2S_DICDIB3MQV3, UBE2S_DROAN
B3NWW9, UBE2S_DROERB4JKB7, UBE2S_DROGRQ9VX25, UBE2S_DROME
B4L7V4, UBE2S_DROMOB4H9W2, UBE2S_DROPEB5DKM4, UBE2S_DROPS
B4IF39, UBE2S_DROSEB4R6G1, UBE2S_DROSIB4MA02, UBE2S_DROVI
B4N208, UBE2S_DROWIB4Q2J2, UBE2S_DROYAQ16763, UBE2S_HUMAN
Q921J4, UBE2S_MOUSEA7SE05, UBE2S_NEMVEB5DFI8, UBE2S_RAT
Q28F89, UBE2S_XENTRQ32LD2, UBE2T_BOVINQ08BH7, UBE2T_DANRE
Q9NPD8, UBE2T_HUMANQ9CQ37, UBE2T_MOUSEQ7ZY08, UBE2T_XENLA
Q5VVX9, UBE2U_HUMANQ95LM1, UBE2U_MACFAA6H795, UBE2W_BOVIN
Q9XWF6, UBE2W_CAEELQ55EY8, UBE2W_DICDIQ96B02, UBE2W_HUMAN
Q8VDW4, UBE2W_MOUSEB5DEI4, UBE2W_RATQ28FC1, UBE2W_XENTR
Q6DG60, UBE2Z_DANREQ9H832, UBE2Z_HUMANQ3UE37, UBE2Z_MOUSE
Q3B7D1, UBE2Z_RATQ6PCF7, UBE2Z_XENLAQ66KB0, UBE2Z_XENTR
Q8SSK3, Y1A1_ENCCU

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-