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ENZYME

ENZYME entry: EC 2.3.2.23

Accepted Name
E2 ubiquitin-conjugating enzyme
Alternative Name(s)
ubiquitin-carrier-protein E2
ubiquitin-conjugating enzyme E2
Reaction catalysed
S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine <=> [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine
Comment(s)
  • The E2 ubiquitin-conjugating enzyme acquires the activated ubquitin from the E1 ubiquitin-activating enzyme (EC 6.2.1.45) and binds it via a transthioesterification reaction to itself.
  • In the human enzyme the catalytic center is located at Cys-87 where ubiquitin is bound via its C-terminal glycine in a thioester linkage.
  • Formerly EC 6.3.2.19.
Cross-references
BRENDA2.3.2.23
EC2PDB2.3.2.23
ExplorEnz2.3.2.23
PRIAM enzyme-specific profiles2.3.2.23
KEGG Ligand Database for Enzyme Nomenclature2.3.2.23
IUBMB Enzyme Nomenclature2.3.2.23
IntEnz2.3.2.23
MEDLINEFind literature relating to 2.3.2.23
MetaCyc2.3.2.23
Rhea expert-curated reactions2.3.2.23
UniProtKB/Swiss-Prot
Q8LGF7, PEX4_ARATHI1RRW0, PEX4_GIBZEQ6ZWY6, U2D2B_MOUSE
P70711, U2D2B_RATQ9VM35, U2QL1_DROMEA1L167, U2QL1_HUMAN
A0PJN4, U2QL1_MOUSEQ2TA10, UB2D1_BOVINP51668, UB2D1_HUMAN
P61080, UB2D1_MOUSED3ZDK2, UB2D1_RATQ1RMX2, UB2D2_BOVIN
P62837, UB2D2_HUMANP62838, UB2D2_MOUSEQ06AA9, UB2D2_PIG
P62839, UB2D2_RATP62840, UB2D2_XENLAQ3ZCF7, UB2D3_BOVIN
P61077, UB2D3_HUMANQ4R5N4, UB2D3_MACFAP61079, UB2D3_MOUSE
Q5R4V7, UB2D3_PONABP61078, UB2D3_RATQ9Y2X8, UB2D4_HUMAN
A5PKP9, UB2D4_XENLAP51965, UB2E1_HUMANP52482, UB2E1_MOUSE
Q96LR5, UB2E2_HUMANQ91W82, UB2E2_MOUSEQ2T9X7, UB2E3_BOVIN
Q969T4, UB2E3_HUMANP52483, UB2E3_MOUSEP62253, UB2G1_HUMAN
Q4R5Y8, UB2G1_MACFAP62254, UB2G1_MOUSEP62255, UB2G1_RAT
Q17QG5, UB2G2_BOVINP60604, UB2G2_HUMANP60605, UB2G2_MOUSE
Q5RF84, UB2G2_PONABQ9Y385, UB2J1_HUMANQ9JJZ4, UB2J1_MOUSE
Q2TA03, UB2J2_BOVINQ54LP7, UB2J2_DICDIQ8N2K1, UB2J2_HUMAN
Q6P073, UB2J2_MOUSEQ54AK6, UB2JL_DICDIQ3MHP1, UB2L3_BOVIN
P68036, UB2L3_HUMANP68037, UB2L3_MOUSEQ5R5I4, UB2L3_PONAB
A0A1B0GUS4, UB2L5_HUMANA5PJC4, UB2L6_BOVINO14933, UB2L6_HUMAN
Q9QZU9, UB2L6_MOUSEQ4V8J2, UB2L6_RATQ7Z7E8, UB2Q1_HUMAN
Q7TSS2, UB2Q1_MOUSEQ32L27, UB2Q2_BOVINQ8WVN8, UB2Q2_HUMAN
Q8K2Z8, UB2Q2_MOUSEQ7YQJ9, UB2Q2_RABITP49427, UB2R1_HUMAN
Q8CFI2, UB2R1_MOUSEQ712K3, UB2R2_HUMANQ6ZWZ2, UB2R2_MOUSE
Q29503, UB2R2_RABITA1L3K1, UB2SA_XENLAQ8AVU2, UB2SB_XENLA
Q76EZ2, UB2SC_XENLAQ4VBH4, UB2WA_DANREQ1JPX4, UB2WB_DANRE
P35133, UBC10_ARATHQ7K738, UBC10_DROMEP35134, UBC11_ARATH
O00103, UBC11_SCHPOP52492, UBC11_YEASTQ9C9Y7, UBC12_ARATH
Q42541, UBC13_ARATHQ95XX0, UBC13_CAEELO13685, UBC13_SCHPO
P52490, UBC13_YEASTP42747, UBC14_ARATHQ9UTN8, UBC14_SCHPO
P42743, UBC15_ARATHQ9Y818, UBC15_SCHPOQ9FWT2, UBC16_ARATH
Q9P6I1, UBC16_SCHPOO23239, UBC17_ARATHQ9FMM0, UBC18_ARATH
Q21633, UBC18_CAEELQ9LJZ5, UBC19_ARATHP25865, UBC1_ARATH
P52478, UBC1_CAEELO74196, UBC1_COLGLQ9UVR2, UBC1_MAGO7
Q5UQC9, UBC1_MIMIVO74810, UBC1_SCHPOP21734, UBC1_YEAST
Q8L7T3, UBC20_ARATHP52484, UBC21_CAEELQ9FF66, UBC22_ARATH
Q9ZVX1, UBC23_ARATHQ8VY10, UBC24_ARATHQ9LUQ5, UBC25_ARATH
Q93571, UBC25_CAEELQ8GY87, UBC26_ARATHQ9FI61, UBC27_ARATH
Q94F47, UBC28_ARATHQ9SLE4, UBC29_ARATHP42745, UBC2_ARATH
Q75EB8, UBC2_ASHGOQ4WLA7, UBC2_ASPFUP35129, UBC2_CAEEL
O74201, UBC2_CANALQ6FR76, UBC2_CANGAP0CS17, UBC2_CRYNB
P0CS16, UBC2_CRYNJQ6BU36, UBC2_DEBHAQ553F3, UBC2_DICDI
Q96UP5, UBC2_EMENIP78717, UBC2_FUSSLQ6CUD9, UBC2_KLULA
P35130, UBC2_MEDSAQ5UQ57, UBC2_MIMIVP52493, UBC2_NEUCR
P23566, UBC2_SCHPOQ58FS2, UBC2_TRIHAQ4PFA5, UBC2_USTMA
P25866, UBC2_WHEATQ6C093, UBC2_YARLIP06104, UBC2_YEAST
Q9FKT3, UBC30_ARATHQ9C8X7, UBC31_ARATHQ9LSP7, UBC32_ARATH
Q9FK29, UBC33_ARATHQ9SHI7, UBC34_ARATHQ94A97, UBC35_ARATH
Q9FZ48, UBC36_ARATHQ941B6, UBC37_ARATHQ9C918, UBC38_ARATH
F4HPP7, UBC39_ARATHP42746, UBC3_ARATHQ5UQ88, UBC3_MIMIV
P14682, UBC3_YEASTP42748, UBC4_ARATHP43102, UBC4_CANAX
Q5UQ40, UBC4_MIMIVP46595, UBC4_SCHPOP35135, UBC4_SOLLC
P16577, UBC4_WHEATP15731, UBC4_YEASTQ8S920, UBC5A_ORYSJ
Q8S919, UBC5B_ORYSJP42749, UBC5_ARATHP15732, UBC5_YEAST
P42750, UBC6_ARATHQ74Z34, UBC6_ASHGOQ6FQK7, UBC6_CANGA
Q6BYG4, UBC6_DEBHAQ6CMG6, UBC6_KLULAO42646, UBC6_SCHPO
P33296, UBC6_YEASTQ42540, UBC7_ARATHP34477, UBC7_CAEEL
O00102, UBC7_SCHPOP25868, UBC7_WHEATQ02159, UBC7_YEAST
P52487, UBC84_DROMEP35131, UBC8_ARATHQ9P7R4, UBC8_SCHPO
P28263, UBC8_YEASTQ94490, UBCB_DICDIP25867, UBCD1_DROME
P52485, UBCD2_DROMEP52486, UBCD4_DROMEP25153, UBCD6_DROME
Q86IZ3, UBCX_DICDIO60015, UBCX_PICANP49428, UBCX_PICPA
P29340, UBCX_YEASTP27949, UBC_ASFB7P0C8G3, UBC_ASFK5
P25869, UBC_ASFM2P0C8G4, UBC_ASFP4P0C8G5, UBC_ASFWA
P49459, UBE2A_HUMANQ9Z255, UBE2A_MOUSEQ32P99, UBE2B_BOVIN
P63146, UBE2B_HUMANP63147, UBE2B_MOUSEP63148, UBE2B_RABIT
P63149, UBE2B_RATQ32PA5, UBE2C_BOVINQ54XS6, UBE2C_DICDI
Q9VTY6, UBE2C_DROMEO00762, UBE2C_HUMANQ4R9D1, UBE2C_MACFA
Q9D1C1, UBE2C_MOUSEQ95044, UBE2C_SPISOP56616, UBE2C_XENLA
Q32LN1, UBE2H_BOVINP62256, UBE2H_HUMANP62257, UBE2H_MOUSE
P61085, UBE2K_BOVINP61086, UBE2K_HUMANP61087, UBE2K_MOUSE
Q0P5K3, UBE2N_BOVINQ86K32, UBE2N_DICDIP35128, UBE2N_DROME
P61088, UBE2N_HUMANQ4R4I1, UBE2N_MACFAP61089, UBE2N_MOUSE
Q5R7J6, UBE2N_PONABQ9EQX9, UBE2N_RATQ1RML1, UBE2S_BOVIN
C3Z724, UBE2S_BRAFLQ4V908, UBE2S_DANREQ54I43, UBE2S_DICDI
B3MQV3, UBE2S_DROANB3NWW9, UBE2S_DROERB4JKB7, UBE2S_DROGR
Q9VX25, UBE2S_DROMEB4L7V4, UBE2S_DROMOB4H9W2, UBE2S_DROPE
B5DKM4, UBE2S_DROPSB4IF39, UBE2S_DROSEB4R6G1, UBE2S_DROSI
B4MA02, UBE2S_DROVIB4N208, UBE2S_DROWIB4Q2J2, UBE2S_DROYA
Q16763, UBE2S_HUMANC1C3R6, UBE2S_LITCTQ921J4, UBE2S_MOUSE
A7SE05, UBE2S_NEMVEB5DFI8, UBE2S_RATQ28F89, UBE2S_XENTR
Q32LD2, UBE2T_BOVINQ08BH7, UBE2T_DANREQ9NPD8, UBE2T_HUMAN
Q9CQ37, UBE2T_MOUSEQ7ZY08, UBE2T_XENLAQ5VVX9, UBE2U_HUMAN
Q95LM1, UBE2U_MACFAA6H795, UBE2W_BOVINQ9XWF6, UBE2W_CAEEL
Q55EY8, UBE2W_DICDIQ96B02, UBE2W_HUMANQ8VDW4, UBE2W_MOUSE
B5DEI4, UBE2W_RATQ28FC1, UBE2W_XENTRQ6DG60, UBE2Z_DANRE
Q9H832, UBE2Z_HUMANQ3UE37, UBE2Z_MOUSEQ3B7D1, UBE2Z_RAT
Q6PCF7, UBE2Z_XENLAQ66KB0, UBE2Z_XENTRQ8SSK3, Y1A1_ENCCU

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-