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ENZYME entry: EC

Accepted Name
E1 ubiquitin-activating enzyme.
Alternative Name(s)
Ubiquitin-activating enzyme E1.
Reaction catalysed
ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine <=> AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine
  • Catalyzes the ATP-dependent activation of ubiquitin through the formation of a thioester bond between the C-terminal glycine of ubiquitin and the sulfhydryl side group of a cysteine residue in the E1 protein.
  • The two-step reaction consists of the ATP-dependent formation of an E1-ubiquitin adenylate intermediate in which the C-terminal glycine of ubiquitin is bound to AMP via an acyl-phosphate linkage, then followed by the conversion to an E1-ubiquitin thioester bond via the cysteine residue on E1 in the second step.
  • Formerly EC and EC
PRIAM enzyme-specific profiles6.2.1.45
KEGG Ligand Database for Enzyme Nomenclature6.2.1.45
IUBMB Enzyme Nomenclature6.2.1.45
MEDLINEFind literature relating to
Rhea expert-curated reactions6.2.1.45
P31254, UBA1Y_MOUSE;  A3KMV5, UBA1_BOVIN;  P52495, UBA1_CANAW;  
Q55C16, UBA1_DICDI;  P22314, UBA1_HUMAN;  Q02053, UBA1_MOUSE;  
Q29504, UBA1_RABIT;  Q5U300, UBA1_RAT;  O94609, UBA1_SCHPO;  
P93028, UBE11_ARATH;  P20973, UBE11_WHEAT;  P92974, UBE12_ARATH;  
P31251, UBE12_WHEAT;  P31252, UBE13_WHEAT;  P31255, UBE1Y_MACRU;  

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