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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.3.2.26

Accepted Name
HECT-type E3 ubiquitin transferase.
Alternative Name(s)
HECT E3 ligase.
Ubiquitin transferase HECT-E3.
Reaction catalysed
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine <=> [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Comment(s)
  • In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond.
  • In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein.
  • Cf. EC 2.3.2.27 and EC 2.3.2.31.
Cross-references
BRENDA2.3.2.26
EC2PDB2.3.2.26
ExplorEnz2.3.2.26
PRIAM enzyme-specific profiles2.3.2.26
KEGG Ligand Database for Enzyme Nomenclature2.3.2.26
IUBMB Enzyme Nomenclature2.3.2.26
IntEnz2.3.2.26
MEDLINEFind literature relating to 2.3.2.26
MetaCyc2.3.2.26
UniProtKB/Swiss-Prot
C6KTB7, ALTH1_PLAF7;  O15033, AREL1_HUMAN;  Q8CHG5, AREL1_MOUSE;  
O17736, ETC1_CAEEL;  Q5F4A1, G2E3_CHICK;  Q7L622, G2E3_HUMAN;  
Q4R9C4, G2E3_MACFA;  Q5RJY2, G2E3_MOUSE;  F1N6G5, HACE1_BOVIN;  
E1C656, HACE1_CHICK;  F8W2M1, HACE1_DANRE;  Q8IYU2, HACE1_HUMAN;  
Q3U0D9, HACE1_MOUSE;  D3ZBM7, HACE1_RAT;  Q6DCL5, HACE1_XENLA;  
Q28BK1, HACE1_XENTR;  V6CLA2, HECD1_CAEEL;  Q9ULT8, HECD1_HUMAN;  
Q69ZR2, HECD1_MOUSE;  Q5U5R9, HECD2_HUMAN;  Q8CDU6, HECD2_MOUSE;  
Q5RD78, HECD2_PONAB;  Q5T447, HECD3_HUMAN;  Q3U487, HECD3_MOUSE;  
Q9Y4D8, HECD4_HUMAN;  Q09291, HECW1_CAEEL;  Q76N89, HECW1_HUMAN;  
Q8K4P8, HECW1_MOUSE;  Q9P2P5, HECW2_HUMAN;  Q6I6G8, HECW2_MOUSE;  
Q15751, HERC1_HUMAN;  Q9VR91, HERC2_DROME;  O95714, HERC2_HUMAN;  
Q4U2R1, HERC2_MOUSE;  Q15034, HERC3_HUMAN;  Q5GLZ8, HERC4_HUMAN;  
Q6PAV2, HERC4_MOUSE;  Q5PQN1, HERC4_RAT;  Q8IVU3, HERC6_HUMAN;  
Q757T0, HUL4_ASHGO;  P40985, HUL4_YEAST;  P53119, HUL5_YEAST;  
Q7Z6Z7, HUWE1_HUMAN;  Q7TMY8, HUWE1_MOUSE;  P51593, HUWE1_RAT;  
P51592, HYD_DROME;  Q96J02, ITCH_HUMAN;  Q8C863, ITCH_MOUSE;  
O94275, MUG30_SCHPO;  Q96PU5, NED4L_HUMAN;  Q8CFI0, NED4L_MOUSE;  
Q5RBF2, NED4L_PONAB;  Q9VVI3, NEDD4_DROME;  P46934, NEDD4_HUMAN;  
P46935, NEDD4_MOUSE;  Q62940, NEDD4_RAT;  O13834, PTR1_SCHPO;  
Q92462, PUB1_SCHPO;  Q9UTG2, PUB2_SCHPO;  O14326, PUB3_SCHPO;  
A1CQG2, RSP5_ASPCL;  B0XQ72, RSP5_ASPFC;  B8N7E5, RSP5_ASPFN;  
Q4WTF3, RSP5_ASPFU;  A2QQ28, RSP5_ASPNC;  Q2UBP1, RSP5_ASPOR;  
Q0CCL1, RSP5_ASPTN;  G0S9J5, RSP5_CHATD;  Q5BDP1, RSP5_EMENI;  
A1D3C5, RSP5_NEOFI;  P39940, RSP5_YEAST;  Q9V853, SMUF1_DROME;  
Q9HCE7, SMUF1_HUMAN;  Q9CUN6, SMUF1_MOUSE;  Q9PUN2, SMUF1_XENLA;  
A9JRZ0, SMUF2_DANRE;  Q9HAU4, SMUF2_HUMAN;  A2A5Z6, SMUF2_MOUSE;  
Q2TAS2, SMUF2_XENLA;  B5EX33, SOPA_SALA4;  Q57MS9, SOPA_SALCH;  
B5FM34, SOPA_SALDC;  Q9S4P4, SOPA_SALDU;  B5QZK6, SOPA_SALEP;  
B4T918, SOPA_SALHS;  B4SX34, SOPA_SALNS;  B4TMK5, SOPA_SALSV;  
D0ZMG9, SOPA_SALT1;  C9X8K0, SOPA_SALTD;  Q8ZNR3, SOPA_SALTY;  
Q8SSY6, SPKUL_DICDI;  Q9Y0H4, SUDX_DROME;  Q756G2, TOM1_ASHGO;  
Q9P4Z1, TOM1_NEUCR;  Q03280, TOM1_YEAST;  E1B7Q7, TRIPC_BOVIN;  
F1RCR6, TRIPC_DANRE;  Q14669, TRIPC_HUMAN;  G5E870, TRIPC_MOUSE;  
F1LP64, TRIPC_RAT;  B4F6W9, TRIPC_XENTR;  Q05086, UBE3A_HUMAN;  
O08759, UBE3A_MOUSE;  Q7Z3V4, UBE3B_HUMAN;  Q9ES34, UBE3B_MOUSE;  
Q08CZ0, UBE3B_XENTR;  Q15386, UBE3C_HUMAN;  Q80U95, UBE3C_MOUSE;  
Q1JQA1, UBE3D_BOVIN;  Q7Z6J8, UBE3D_HUMAN;  Q8BX13, UBE3D_MOUSE;  
Q5RFG8, UBE3D_PONAB;  Q3T1H6, UBE3D_RAT;  O95071, UBR5_HUMAN;  
Q80TP3, UBR5_MOUSE;  Q62671, UBR5_RAT;  Q9VL06, UFD4_DROME;  
P33202, UFD4_YEAST;  Q8GY23, UPL1_ARATH;  Q8H0T4, UPL2_ARATH;  
Q6WWW4, UPL3_ARATH;  Q9LYZ7, UPL4_ARATH;  Q9SU29, UPL5_ARATH;  
Q8RWB8, UPL6_ARATH;  Q9SCQ2, UPL7_ARATH;  Q9H0M0, WWP1_HUMAN;  
Q8BZZ3, WWP1_MOUSE;  O00308, WWP2_HUMAN;  Q9DBH0, WWP2_MOUSE;  
Q10435, YDE1_SCHPO;  Q1K9C4, YFK7_SCHPO;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-