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ENZYME

ENZYME entry: EC 2.3.2.26

Accepted Name
HECT-type E3 ubiquitin transferase
Alternative Name(s)
HECT E3 ligase
ubiquitin transferase HECT-E3
Reaction catalysed
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Comment(s)
  • In the first step the enzyme transfers ubiquitin from the E2 ubiquitin-conjugating enzyme (EC 2.3.2.23) to a cysteine residue in its HECT domain (which is located in the C-terminal region), forming a thioester bond.
  • In a subsequent step the enzyme transfers the ubiquitin to an acceptor protein, resulting in the formation of an isopeptide bond between the C-terminal glycine residue of ubiquitin and the epsilon- amino group of an L-lysine residue of the acceptor protein. cf. EC 2.3.2.27 and EC 2.3.2.31.
Cross-references
BRENDA2.3.2.26
EC2PDB2.3.2.26
ExplorEnz2.3.2.26
PRIAM enzyme-specific profiles2.3.2.26
KEGG Ligand Database for Enzyme Nomenclature2.3.2.26
IUBMB Enzyme Nomenclature2.3.2.26
IntEnz2.3.2.26
MEDLINEFind literature relating to 2.3.2.26
MetaCyc2.3.2.26
Rhea expert-curated reactions2.3.2.26
UniProtKB/Swiss-Prot
C6KTB7, ALTH1_PLAF7O15033, AREL1_HUMANQ8CHG5, AREL1_MOUSE
O17736, ETC1_CAEELQ5F4A1, G2E3_CHICKQ7L622, G2E3_HUMAN
Q4R9C4, G2E3_MACFAQ5RJY2, G2E3_MOUSEF1N6G5, HACE1_BOVIN
E1C656, HACE1_CHICKF8W2M1, HACE1_DANREQ8IYU2, HACE1_HUMAN
Q3U0D9, HACE1_MOUSED3ZBM7, HACE1_RATQ6DCL5, HACE1_XENLA
Q28BK1, HACE1_XENTRV6CLA2, HECD1_CAEELQ9ULT8, HECD1_HUMAN
Q69ZR2, HECD1_MOUSEQ5U5R9, HECD2_HUMANQ8CDU6, HECD2_MOUSE
Q5RD78, HECD2_PONABQ5T447, HECD3_HUMANQ3U487, HECD3_MOUSE
Q9Y4D8, HECD4_HUMANQ09291, HECW1_CAEELQ76N89, HECW1_HUMAN
Q8K4P8, HECW1_MOUSEQ9P2P5, HECW2_HUMANQ6I6G8, HECW2_MOUSE
Q15751, HERC1_HUMANQ9VR91, HERC2_DROMEO95714, HERC2_HUMAN
Q4U2R1, HERC2_MOUSEQ15034, HERC3_HUMANQ5GLZ8, HERC4_HUMAN
Q6PAV2, HERC4_MOUSEQ5PQN1, HERC4_RATQ8IVU3, HERC6_HUMAN
Q757T0, HUL4_EREGSP40985, HUL4_YEASTP53119, HUL5_YEAST
Q7Z6Z7, HUWE1_HUMANQ7TMY8, HUWE1_MOUSEP51593, HUWE1_RAT
P51592, HYD_DROMEQ96J02, ITCH_HUMANQ8C863, ITCH_MOUSE
O94275, MUG30_SCHPOQ96PU5, NED4L_HUMANQ8CFI0, NED4L_MOUSE
Q5RBF2, NED4L_PONABQ9VVI3, NEDD4_DROMEP46934, NEDD4_HUMAN
P46935, NEDD4_MOUSEQ62940, NEDD4_RATO13834, PTR1_SCHPO
Q92462, PUB1_SCHPOQ9UTG2, PUB2_SCHPOO14326, PUB3_SCHPO
A1CQG2, RSP5_ASPCLB0XQ72, RSP5_ASPFCB8N7E5, RSP5_ASPFN
Q4WTF3, RSP5_ASPFUA2QQ28, RSP5_ASPNCQ2UBP1, RSP5_ASPOR
Q0CCL1, RSP5_ASPTNG0S9J5, RSP5_CHATDQ5BDP1, RSP5_EMENI
A1D3C5, RSP5_NEOFIP39940, RSP5_YEASTQ9V853, SMUF1_DROME
Q9HCE7, SMUF1_HUMANQ9CUN6, SMUF1_MOUSEQ9PUN2, SMUF1_XENLA
A9JRZ0, SMUF2_DANREQ9HAU4, SMUF2_HUMANA2A5Z6, SMUF2_MOUSE
Q2TAS2, SMUF2_XENLAB5EX33, SOPA_SALA4Q57MS9, SOPA_SALCH
B5FM34, SOPA_SALDCQ9S4P4, SOPA_SALDUB5QZK6, SOPA_SALEP
B4T918, SOPA_SALHSB4SX34, SOPA_SALNSB4TMK5, SOPA_SALSV
D0ZMG9, SOPA_SALT1C9X8K0, SOPA_SALTDQ8ZNR3, SOPA_SALTY
Q8SSY6, SPKUL_DICDIQ9Y0H4, SUDX_DROMEQ756G2, TOM1_EREGS
Q9P4Z1, TOM1_NEUCRQ03280, TOM1_YEASTE1B7Q7, TRIPC_BOVIN
F1RCR6, TRIPC_DANREQ14669, TRIPC_HUMANG5E870, TRIPC_MOUSE
F1LP64, TRIPC_RATB4F6W9, TRIPC_XENTRQ05086, UBE3A_HUMAN
O08759, UBE3A_MOUSEQ7Z3V4, UBE3B_HUMANQ9ES34, UBE3B_MOUSE
Q08CZ0, UBE3B_XENTRQ15386, UBE3C_HUMANQ80U95, UBE3C_MOUSE
Q1JQA1, UBE3D_BOVINQ7Z6J8, UBE3D_HUMANQ8BX13, UBE3D_MOUSE
Q5RFG8, UBE3D_PONABQ3T1H6, UBE3D_RATO95071, UBR5_HUMAN
Q80TP3, UBR5_MOUSEQ62671, UBR5_RATQ9VL06, UFD4_DROME
P33202, UFD4_YEASTQ8GY23, UPL1_ARATHQ8H0T4, UPL2_ARATH
Q6WWW4, UPL3_ARATHQ9LYZ7, UPL4_ARATHQ9SU29, UPL5_ARATH
Q8RWB8, UPL6_ARATHQ9SCQ2, UPL7_ARATHQ9N2Z7, WWP1_CAEEL
Q9H0M0, WWP1_HUMANQ8BZZ3, WWP1_MOUSEO00308, WWP2_HUMAN
Q9DBH0, WWP2_MOUSEQ10435, YDE1_SCHPOQ1K9C4, YFK7_SCHPO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
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