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ENZYME

ENZYME entry: EC 2.3.3.14

PURL: https://purl.expasy.org/enzyme/EC/2.3.3.14
Accepted Name
homocitrate synthase
Alternative Name(s)
2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating)
acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase
homocitrate synthetase
Reaction catalysed
acetyl-CoA + 2-oxoglutarate + H2O = (2R)-homocitrate + CoA + H(+)
Comment(s)
  • Belongs in the alpha-aminoadipate pathway of lysine synthesis, along with EC 4.2.1.36.
  • Also acts with oxaloacetate as substrate, but more slowly.
  • Formerly EC 4.1.3.21.
Cross-references
BRENDA2.3.3.14
EC2PDB2.3.3.14
ExplorEnz2.3.3.14
KEGG Ligand Database for Enzyme Nomenclature2.3.3.14
IUBMB Enzyme Nomenclature2.3.3.14
MEDLINEFind literature relating to 2.3.3.14
MetaCyc2.3.3.14
Rhea expert-curated reactions2.3.3.14
UniProtKB/Swiss-Prot
Q8TKQ6, AKSA_METACQ57926, AKSA_METJAQ8TW28, AKSA_METKA
P58967, AKSA_METMAO27667, AKSA_METTHQ9V1J1, HOSA_PYRAB
O59390, HOSA_PYRHOC3NHU6, HOSA_SACI1C3MPM7, HOSA_SACI2
C3N5A3, HOSA_SACI3C3MYM1, HOSA_SACI4C4KGW9, HOSA_SACI6
C3NDV7, HOSA_SACI7Q97ZE0, HOSA_SACS2Q4J989, HOSA_SULAC
Q971S5, HOSA_SULTOO87198, HOSA_THET2P48570, HOSC_YEAST
O94225, HOSM_PENRWQ9Y823, HOSM_SCHPOQ12726, HOSM_YARLI
Q12122, HOSM_YEASTQ44290, NIFV1_NOSS1P58637, NIFV2_NOSS1
Q00853, NIFVA_CLOPAQ00852, NIFVO_CLOPAP70728, NIFV_AZOBR
P23122, NIFV_AZOCHP05342, NIFV_AZOVIQ01181, NIFV_CERSP
Q52070, NIFV_ENTAGQ47884, NIFV_FRAALP54610, NIFV_FRASP
P05345, NIFV_KLEPNQ07179, NIFV_RHOCA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-