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ENZYME

ENZYME entry: EC 4.2.1.36

Accepted Name
homoaconitate hydratase
Alternative Name(s)
2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase
cis-homoaconitase
HACN
homoaconitase
Reaction catalysed
(2R,3S)-homoisocitrate = cis-homoaconitate + H2O
Comment(s)
  • The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyze the reaction shown above but cannot catalyze the previously described reaction, i.e. formation of homocitrate by hydration of cis-homoaconitate.
  • The enzyme responsible for the conversion of cis-homoaconitate into homocitrate in T.thermophilus is unknown at present but the reaction can be catalyzed in vitro using EC 4.2.1.3 from pig.
Cross-references
BRENDA4.2.1.36
EC2PDB4.2.1.36
ExplorEnz4.2.1.36
PRIAM enzyme-specific profiles4.2.1.36
KEGG Ligand Database for Enzyme Nomenclature4.2.1.36
IUBMB Enzyme Nomenclature4.2.1.36
IntEnz4.2.1.36
MEDLINEFind literature relating to 4.2.1.36
MetaCyc4.2.1.36
Rhea expert-curated reactions4.2.1.36
UniProtKB/Swiss-Prot
Q9ZNE0, HACA_THET2Q9ZND9, HACB_THET2Q4WUL6, LYS4_ASPFU
Q58FL6, LYS4_ASPNCQ2U9G3, LYS4_ASPORQ5A644, LYS4_CANAL
Q6FM51, LYS4_CANGAQ2HZ33, LYS4_CANPAQ2GN26, LYS4_CHAGB
P0CM03, LYS4_CRYNBP0CM02, LYS4_CRYNJQ6BM98, LYS4_DEBHA
Q92412, LYS4_EMENIQ75DX9, LYS4_EREGSQ4HVQ9, LYS4_GIBZE
Q6CT61, LYS4_KLULAQ4P521, LYS4_MYCMDQ870W1, LYS4_NEUCR
Q9UT74, LYS4_SCHPOQ6C791, LYS4_YARLIP49367, LYS4_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-