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ENZYME

ENZYME entry: EC 2.3.3.21

Accepted Name
(R)-citramalate synthase
Reaction catalysed
acetyl-CoA + H2O + pyruvate <=> (3R)-citramalate + CoA + H(+)
Comment(s)
  • One of the enzymes involved in a pyruvate-derived pathway for isoleucine biosynthesis that is found in some bacterial and archaeal species.
  • The enzyme can be inhibited by isoleucine, the end-product of the pathway, but not by leucine.
  • The enzyme is highly specific for pyruvate as substrate, as the 2-oxo acids 3-methyl-2-oxobutanoate, 2-oxobutanoate, 4-methyl-2- oxopentanoate, 2-oxohexanoate and 2-oxoglutarate cannot act as substrate.
  • Formerly EC 2.3.1.182.
Cross-references
BRENDA2.3.3.21
EC2PDB2.3.3.21
ExplorEnz2.3.3.21
PRIAM enzyme-specific profiles2.3.3.21
KEGG Ligand Database for Enzyme Nomenclature2.3.3.21
IUBMB Enzyme Nomenclature2.3.3.21
IntEnz2.3.3.21
MEDLINEFind literature relating to 2.3.3.21
MetaCyc2.3.3.21
Rhea expert-curated reactions2.3.3.21
UniProtKB/Swiss-Prot
O66682, CIMA_AQUAEO29305, CIMA_ARCFUQ74C76, CIMA_GEOSL
Q8F3Q1, CIMA_LEPINQ8TJJ1, CIMA_METACQ58787, CIMA_METJA
Q8TYM1, CIMA_METKAP58966, CIMA_METMAA3CUF2, CIMA_METMJ
B8GEI1, CIMA_METPEO26819, CIMA_METTHO86511, CIMA_STRCO
Q4J6H1, CIMA_SULACP74269, CIMA_SYNY3Q9WZ22, CIMA_THEMA

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