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ENZYME entry: EC 2.3.3.5

Accepted Name
2-methylcitrate synthase.
Alternative Name(s)
2-methylcitrate oxaloacetate-lyase.
MCS.
Methylcitrate synthase.
Methylcitrate synthetase.
Reaction catalysed
Propanoyl-CoA + H(2)O + oxaloacetate <=> (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate + CoA
Comment(s)
  • The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA.
  • The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1.
  • Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
  • Formerly EC 4.1.3.31.
Cross-references
PROSITEPDOC00422
BRENDA2.3.3.5
EC2PDB2.3.3.5
ExplorEnz2.3.3.5
PRIAM enzyme-specific profiles2.3.3.5
KEGG Ligand Database for Enzyme Nomenclature2.3.3.5
IUBMB Enzyme Nomenclature2.3.3.5
IntEnz2.3.3.5
MEDLINEFind literature relating to 2.3.3.5
MetaCyc2.3.3.5
Rhea expert-curated reactions2.3.3.5
UniProtKB/Swiss-Prot
Q8NSH7, PRPC1_CORGL;  Q8NSL1, PRPC2_CORGL;  O34002, PRPC_ABDS2;  
B0YD89, PRPC_ASPFC;  Q50I20, PRPC_ASPFM;  Q937N9, PRPC_CUPNE;  
P31660, PRPC_ECOLI;  Q9TEM3, PRPC_EMENI;  C7C435, PRPC_FUSSL;  
C7C436, PRPC_GIBMO;  H8F0D7, PRPC_MYCTE;  I6Y9Q3, PRPC_MYCTU;  
Q56063, PRPC_SALTY;  Q8EJW2, PRPC_SHEON;  Q6C793, PRPC_YARLI;  

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