ENZYME entry: EC 2.3.3.5
Accepted Name |
2-methylcitrate synthase.
|
Alternative Name(s) |
2-methylcitrate oxaloacetate-lyase. |
MCS. |
methylcitrate synthase. |
methylcitrate synthetase. |
Reaction catalysed |
H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+) |
Comment(s) |
- The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and
pentanoyl-CoA.
- The relative rate of condensation of acetyl-CoA and oxaloacetate is
140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is
distinct from EC 2.3.3.1.
- Oxaloacetate cannot be replaced by glyoxylate, pyruvate or
2-oxoglutarate.
- Formerly EC 4.1.3.31.
|
Cross-references |
BRENDA | 2.3.3.5 |
EC2PDB | 2.3.3.5 |
ExplorEnz | 2.3.3.5 |
PRIAM enzyme-specific profiles | 2.3.3.5 |
KEGG Ligand Database for Enzyme Nomenclature | 2.3.3.5 |
IUBMB Enzyme Nomenclature | 2.3.3.5 |
IntEnz | 2.3.3.5 |
MEDLINE | Find literature relating to 2.3.3.5 |
MetaCyc | 2.3.3.5 |
Rhea expert-curated reactions | 2.3.3.5 |
UniProtKB/Swiss-Prot |
Q8NSH7, PRPC1_CORGL; | Q8NSL1, PRPC2_CORGL; | O34002, PRPC_ABDS2; |
B0YD89, PRPC_ASPFC; | Q50I20, PRPC_ASPFM; | Q937N9, PRPC_CUPNE; |
P31660, PRPC_ECOLI; | Q9TEM3, PRPC_EMENI; | C7C435, PRPC_FUSSL; |
C7C436, PRPC_GIBMO; | H8F0D7, PRPC_MYCTE; | I6Y9Q3, PRPC_MYCTU; |
Q56063, PRPC_SALTY; | Q8EJW2, PRPC_SHEON; | Q6C793, PRPC_YARLI; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
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