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ENZYME

ENZYME entry: EC 2.3.3.5

Accepted Name
2-methylcitrate synthase
Alternative Name(s)
2-methylcitrate oxaloacetate-lyase
MCS
methylcitrate synthase
methylcitrate synthetase
Reaction catalysed
H2O + oxaloacetate + propanoyl-CoA <=> (2S,3S)-2-methylcitrate + CoA + H(+)
Comment(s)
  • The enzyme acts on acetyl-CoA, propanoyl-CoA, butanoyl-CoA and pentanoyl-CoA.
  • The relative rate of condensation of acetyl-CoA and oxaloacetate is 140% of that of propanoyl-CoA and oxaloacetate, but the enzyme is distinct from EC 2.3.3.1.
  • Oxaloacetate cannot be replaced by glyoxylate, pyruvate or 2-oxoglutarate.
  • Formerly EC 4.1.3.31.
Cross-references
BRENDA2.3.3.5
EC2PDB2.3.3.5
ExplorEnz2.3.3.5
PRIAM enzyme-specific profiles2.3.3.5
KEGG Ligand Database for Enzyme Nomenclature2.3.3.5
IUBMB Enzyme Nomenclature2.3.3.5
IntEnz2.3.3.5
MEDLINEFind literature relating to 2.3.3.5
MetaCyc2.3.3.5
Rhea expert-curated reactions2.3.3.5
UniProtKB/Swiss-Prot
Q8NSH7, PRPC1_CORGLQ8NSL1, PRPC2_CORGLO34002, PRPC_ABDS2
B0YD89, PRPC_ASPFCQ50I20, PRPC_ASPFMQ937N9, PRPC_CUPNE
P31660, PRPC_ECOLIQ9TEM3, PRPC_EMENIC7C435, PRPC_FUSSL
C7C436, PRPC_GIBMOH8F0D7, PRPC_MYCTEI6Y9Q3, PRPC_MYCTU
Q56063, PRPC_SALTYQ8EJW2, PRPC_SHEONQ6C793, PRPC_YARLI

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-