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ENZYME entry: EC 2.4.1.1

Accepted Name
glycogen phosphorylase
Alternative Name(s)
amylophosphorylase
muscle phosphorylase a and b
polyphosphorylase
Reaction catalysed
[(1->4)-alpha-D-glucosyl](n) + phosphate <=> [(1->4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate
Comment(s)
  • This entry covers several enzymes from different sources that act in vivo on different forms of (1->4)-alpha-D-glucans.
  • Some of these enzymes catalyze the first step in the degradation of large branched glycan polymers - the phosphorolytic cleavage of alpha-1,4-glucosidic bonds from the non-reducing ends of linear poly(1->4)-alpha-D-glucosyl chains within the polymers.
  • The enzyme stops when it reaches the fourth residue away from an alpha-1,6 branching point, leaving a highly branched core known as a limit dextrin.
  • The description (accepted name) of the enzyme should be modified for each specific instance by substituting 'glycogen' with the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, etc.
Cross-references
BRENDA2.4.1.1
EC2PDB2.4.1.1
ExplorEnz2.4.1.1
PRIAM enzyme-specific profiles2.4.1.1
KEGG Ligand Database for Enzyme Nomenclature2.4.1.1
IUBMB Enzyme Nomenclature2.4.1.1
IntEnz2.4.1.1
MEDLINEFind literature relating to 2.4.1.1
MetaCyc2.4.1.1
Rhea expert-curated reactions2.4.1.1
UniProtKB/Swiss-Prot
Q9LIB2, PHS1_ARATHQ00766, PHS1_DICDIQ9SD76, PHS2_ARATH
P34114, PHS2_DICDIO66932, PHSG_AQUAEP39123, PHSG_BACSU
Q9PKE6, PHSG_CHLMUQ9Z8N1, PHSG_CHLPNO84250, PHSG_CHLTR
P0AC86, PHSG_ECOLIP45180, PHSG_HAEINQ7U078, PHSG_MYCBO
P9WMW0, PHSG_MYCTOP9WMW1, PHSG_MYCTUQ9CN90, PHSG_PASMU
P0AC87, PHSG_SHIFLP73511, PHSG_SYNY3Q9YGA7, PHSG_THELN
P06738, PHSG_YEASTP32811, PHSH_SOLTUP53537, PHSH_VICFA
Q9LKJ3, PHSH_WHEATP04045, PHSL1_SOLTUP53535, PHSL2_SOLTU
P27598, PHSL_IPOBAP53536, PHSL_VICFAP00490, PHSM_ECOLI
P07094, PHSM_KLEPNP29849, PHSM_STRPNQ3B7M9, PYGB_BOVIN
P11216, PYGB_HUMANQ8CI94, PYGB_MOUSEQ5R5M6, PYGB_PONAB
P53534, PYGB_RATQ5MIB6, PYGB_SHEEPQ0VCM4, PYGL_BOVIN
P06737, PYGL_HUMANQ9ET01, PYGL_MOUSEP09811, PYGL_RAT
Q5MIB5, PYGL_SHEEPP79334, PYGM_BOVINP11217, PYGM_HUMAN
Q8HXW4, PYGM_MACFAQ9WUB3, PYGM_MOUSEP00489, PYGM_RABIT
P09812, PYGM_RATO18751, PYGM_SHEEPQ9XTL9, PYG_DROME

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