Home  |  Contact
Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm CEST. Apologies for the inconvenience.

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.
GlcNAc-T I.
N-acetylglucosaminyltransferase I.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I.
Uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta- 1,2-N-acetylglucosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein]
  • The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
  • Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act.
  • While the natural substrate (produced by EC is described here, the minimal substrate recognized by the enzyme is alpha-D-Man- (1->3)-beta-D-Man-R.
  • Formerly EC
PRIAM enzyme-specific profiles2.4.1.101
KEGG Ligand Database for Enzyme Nomenclature2.4.1.101
IUBMB Enzyme Nomenclature2.4.1.101
MEDLINEFind literature relating to
Q9XGM8, MGAT1_ARATH;  Q11068, MGAT1_CAEEL;  P26572, MGAT1_HUMAN;  
P27808, MGAT1_MOUSE;  P27115, MGAT1_RABIT;  Q09325, MGAT1_RAT;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-