ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.101

Accepted Name

Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.

Alternative Name(s)

Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.

GlcNAc-T I.

GnTI.

N-acetylglucosaminyltransferase I.

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I.

Uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta- 1,2-N-acetylglucosaminyltransferase.

Reaction catalysed

UDP-N-acetyl-alpha-D-glucosamine + alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein]

Comment(s)

The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act.
While the natural substrate (produced by EC 3.2.1.113) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man- (1->3)-beta-D-Man-R.
Formerly EC 2.4.1.51.

Cross-references

BRENDA

2.4.1.101

EC2PDB

2.4.1.101

ExplorEnz

2.4.1.101

PRIAM enzyme-specific profiles

2.4.1.101

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.101

IUBMB Enzyme Nomenclature