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ENZYME entry: EC 2.4.1.101

Accepted Name
alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.
GlcNAc-T I.
GnTI.
N-acetylglucosaminyltransferase I.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I.
uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta- 1,2-N-acetylglucosaminyltransferase.
Reaction catalysed
N(4)-(alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc)-L-asparaginyl-[protein] (N-glucan mannose isomer 5A1,2) + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
Comment(s)
  • The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
  • Its action is required before the other N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II through VI) can act.
  • While the natural substrate (produced by EC 3.2.1.113) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man- (1->3)-beta-D-Man-R.
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.101
EC2PDB2.4.1.101
ExplorEnz2.4.1.101
PRIAM enzyme-specific profiles2.4.1.101
KEGG Ligand Database for Enzyme Nomenclature2.4.1.101
IUBMB Enzyme Nomenclature2.4.1.101
IntEnz2.4.1.101
MEDLINEFind literature relating to 2.4.1.101
MetaCyc2.4.1.101
Rhea expert-curated reactions2.4.1.101
UniProtKB/Swiss-Prot
Q9XGM8, MGAT1_ARATH;  Q11068, MGAT1_CAEEL;  P26572, MGAT1_HUMAN;  
P27808, MGAT1_MOUSE;  P27115, MGAT1_RABIT;  Q09325, MGAT1_RAT;  

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