ENZYME entry: EC 2.4.1.101
| Accepted Name |
|---|
| Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
|
| Alternative Name(s) |
|---|
| Alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase. |
| GlcNAc-T I. |
| GnTI. |
| N-acetylglucosaminyltransferase I. |
| N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
I. |
| Uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-
1,2-N-acetylglucosaminyltransferase. |
| Reaction catalysed |
|---|
| UDP-N-acetyl-alpha-D-glucosamine + alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-N-Asn-[protein] |
| Comment(s) |
|---|
- The enzyme, found in plants and animals, participates in the
processing of N-glycans in the Golgi apparatus.
- Its action is required before the other
N-acetylglucosaminyltransferases involved in the process (GlcNAcT-II
through VI) can act.
- While the natural substrate (produced by EC 3.2.1.113) is described
here, the minimal substrate recognized by the enzyme is alpha-D-Man-
(1->3)-beta-D-Man-R.
- Formerly EC 2.4.1.51.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.101 |
| EC2PDB | 2.4.1.101 |
| ExplorEnz | 2.4.1.101 |
| PRIAM enzyme-specific profiles | 2.4.1.101 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.101 |
| IUBMB Enzyme Nomenclature | 2.4.1.101 |
| IntEnz | 2.4.1.101 |
| MEDLINE | Find literature relating to 2.4.1.101 |
| MetaCyc | 2.4.1.101 |
| UniProtKB/Swiss-Prot |
|
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