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ENZYME entry: EC 3.2.1.113

Accepted Name
Mannosyl-oligosaccharide 1,2-alpha-mannosidase.
Alternative Name(s)
Man9-mannosidase.
ManI.
Mannosidase 1A.
Mannosidase 1B.
Reaction catalysed
  • Man(9)GlcNAc(2)-[protein] + 4 H(2)O <=> Man(5)GlcNAc(2)-[protein] + 4 beta-D-mannopyranose
  • Man(8)GlcNAc(2)-[protein] (isomer 8A(1,2,3)B(1,3)) + 3 H(2)O <=> Man(5)GlcNAc(2)-[protein] + 3 beta-D-mannopyranose
Comment(s)
  • This family of mammalian enzymes, located in the Golgi system, participates in the maturation process of N-glycans that leads to formation of hybrid and complex structures.
  • The enzymes catalyze the hydrolysis of the four (1->2)-linked alpha- D-mannose residues from the Man(9)GlcNAc(2) oligosaccharide attached to target proteins.
  • Alternatively, the enzymes act on the Man(8)GlcNAc(2) isomer formed by EC 3.2.1.209.
  • The enzymes are type II membrane proteins, require Ca(2+), and use an inverting mechanism.
  • While all three human enzymes can catalyze the reactions listed here, some of the enzymes can additionally catalyze hydrolysis in an alternative order, generating additional isomeric intermediates, although the final product is the same.
  • The names of the isomers listed here are based on a nomenclature system proposed by Prien et al.
Cross-references
BRENDA3.2.1.113
EC2PDB3.2.1.113
ExplorEnz3.2.1.113
PRIAM enzyme-specific profiles3.2.1.113
KEGG Ligand Database for Enzyme Nomenclature3.2.1.113
IUBMB Enzyme Nomenclature3.2.1.113
IntEnz3.2.1.113
MEDLINEFind literature relating to 3.2.1.113
MetaCyc3.2.1.113
UniProtKB/Swiss-Prot
Q9BZQ6, EDEM3_HUMAN;  Q2HXL6, EDEM3_MOUSE;  Q6GQB9, EDEM3_XENLA;  
P53624, MA1A1_DROME;  P33908, MA1A1_HUMAN;  P45700, MA1A1_MOUSE;  
O02773, MA1A1_PIG;  P45701, MA1A1_RABIT;  O60476, MA1A2_HUMAN;  
P39098, MA1A2_MOUSE;  Q9UKM7, MA1B1_HUMAN;  A2AJ15, MA1B1_MOUSE;  
B2GUY0, MA1B1_RAT;  Q9NR34, MA1C1_HUMAN;  Q18788, MAN12_CAEEL;  
P31723, MAN12_PENCI;  D4AV26, MNS1B_ARTBC;  A1CP08, MNS1B_ASPCL;  
B0XMT4, MNS1B_ASPFC;  B8N417, MNS1B_ASPFN;  Q4WRZ5, MNS1B_ASPFU;  
A2QAS2, MNS1B_ASPNC;  Q2ULB2, MNS1B_ASPOR;  Q12563, MNS1B_ASPPH;  
Q0D076, MNS1B_ASPTN;  E9CXX8, MNS1B_COCPS;  Q5BF93, MNS1B_EMENI;  
A1D1W1, MNS1B_NEOFI;  Q9C512, MNS1_ARATH;  Q8J0Q0, MNS1_CANAX;  
Q9P7C3, MNS1_SCHPO;  P32906, MNS1_YEAST;  Q8H116, MNS2_ARATH;  
Q93Y37, MNS3_ARATH;  

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