ENZYME entry: EC 2.4.1.131
| Accepted Name |
|---|
| GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase.
|
| Reaction catalysed |
|---|
| 2 GDP-alpha-D-mannose + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> 2 GDP + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol |
| Comment(s) |
|---|
- The biosynthesis of asparagine-linked glycoproteins (N-linked protein
glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor,
which is assembled by the series of membrane-bound
glycosyltransferases that comprise the dolichol pathway.
- ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out
two sequential steps in the formation of the lipid-linked core
oligosaccharide, adding two mannose residues in alpha(1->2) linkages
to the nascent oligosaccharide.
- Formerly EC 2.4.1.n4.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.131 |
| EC2PDB | 2.4.1.131 |
| ExplorEnz | 2.4.1.131 |
| PRIAM enzyme-specific profiles | 2.4.1.131 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.131 |
| IUBMB Enzyme Nomenclature | 2.4.1.131 |
| IntEnz | 2.4.1.131 |
| MEDLINE | Find literature relating to 2.4.1.131 |
| MetaCyc | 2.4.1.131 |
| UniProtKB/Swiss-Prot |
| Q9XEE9, ALG11_ARATH; | Q75B12, ALG11_ASHGO; | P53993, ALG11_CAEEL; |
| Q59S72, ALG11_CANAL; | Q6FWD1, ALG11_CANGA; | Q7ZW24, ALG11_DANRE; |
| Q6BVB2, ALG11_DEBHA; | Q54DM9, ALG11_DICDI; | Q2TAA5, ALG11_HUMAN; |
| Q6CLD6, ALG11_KLULA; | Q3TZM9, ALG11_MOUSE; | Q8X092, ALG11_NEUCR; |
| Q5R7Z6, ALG11_PONAB; | O74878, ALG11_SCHPO; | Q08B22, ALG11_XENLA; |
| Q6P312, ALG11_XENTR; | Q6C9T3, ALG11_YARLI; | P53954, ALG11_YEAST; |
|
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