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ENZYME

ENZYME entry: EC 2.4.1.131

Accepted Name
GDP-Man:Man3GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase
Reaction catalysed
alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose <=> alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H(+)
Comment(s)
  • The biosynthesis of asparagine-linked glycoproteins (N-linked protein glycosylation) utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway.
  • ALG11 mannosyltransferase from Saccharomyces cerevisiae carries out two sequential steps in the formation of the lipid-linked core oligosaccharide, adding two mannose residues in alpha(1->2) linkages to the nascent oligosaccharide.
  • Formerly EC 2.4.1.n4.
Cross-references
BRENDA2.4.1.131
EC2PDB2.4.1.131
ExplorEnz2.4.1.131
PRIAM enzyme-specific profiles2.4.1.131
KEGG Ligand Database for Enzyme Nomenclature2.4.1.131
IUBMB Enzyme Nomenclature2.4.1.131
IntEnz2.4.1.131
MEDLINEFind literature relating to 2.4.1.131
MetaCyc2.4.1.131
Rhea expert-curated reactions2.4.1.131
UniProtKB/Swiss-Prot
Q9XEE9, ALG11_ARATHQ75B12, ALG11_ASHGOP53993, ALG11_CAEEL
Q59S72, ALG11_CANALQ6FWD1, ALG11_CANGBQ7ZW24, ALG11_DANRE
Q6BVB2, ALG11_DEBHAQ54DM9, ALG11_DICDIQ2TAA5, ALG11_HUMAN
Q6CLD6, ALG11_KLULCQ3TZM9, ALG11_MOUSEQ8X092, ALG11_NEUCR
Q5R7Z6, ALG11_PONABO74878, ALG11_SCHPOQ08B22, ALG11_XENLA
Q6P312, ALG11_XENTRQ6C9T3, ALG11_YARLIP53954, ALG11_YEAST

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