ENZYME entry: EC 2.4.1.132

Accepted Name

GDP-Man:Man1GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase

Alternative Name(s)

GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase

mannosyltransferase II

Reaction catalysed

beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+)

Comment(s)

The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway.
Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha1,3-mannosylation of D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D- GlcNAc-diphosphodolichol, followed by an alpha1,6-mannosylation (cf. EC 2.4.1.257), to form the first branched pentasaccharide intermediate of the dolichol pathway.

Cross-references

BRENDA

2.4.1.132

EC2PDB

2.4.1.132

ExplorEnz

2.4.1.132

PRIAM enzyme-specific profiles

2.4.1.132

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.132

IUBMB Enzyme Nomenclature

2.4.1.132

IntEnz

2.4.1.132

MEDLINE

Find literature relating to 2.4.1.132

MetaCyc

2.4.1.132

Rhea expert-curated reactions

2.4.1.132

UniProtKB/Swiss-Prot

Q59LF2, ALG2_CANAL	Q6FJJ9, ALG2_CANGA	Q6BVA4, ALG2_DEBHA
Q7KWM5, ALG2_DICDI	Q755C1, ALG2_EREGS	Q9H553, ALG2_HUMAN
Q6CWQ0, ALG2_KLULA	Q9DBE8, ALG2_MOUSE	Q8X0H8, ALG2_NEUCR
O94738, ALG2_RHIPU	Q96WW6, ALG2_SCHPO	Q6C3V7, ALG2_YARLI
P43636, ALG2_YEAST

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