ENZYME entry: EC 2.4.1.257

Accepted Name
GDP-Man:Man(2)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase.
Alternative Name(s)
GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase.
Reaction catalysed
GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol
Comment(s)
  • The biosynthesis of asparagine-linked glycoproteins utilizes a dolichyl diphosphate-linked glycosyl donor, which is assembled by the series of membrane-bound glycosyltransferases that comprise the dolichol pathway.
  • Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an alpha-1,3-mannosylation (cf. EC 2.4.1.132) of D-Man-beta-(1->4)-D- GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol, followed by an alpha- 1,6-mannosylation, to form the first branched pentasaccharide intermediate of the dolichol pathway.
Cross-references
BRENDA2.4.1.257
EC2PDB2.4.1.257
ExplorEnz2.4.1.257
PRIAM enzyme-specific profiles2.4.1.257
KEGG Ligand Database for Enzyme Nomenclature2.4.1.257
IUBMB Enzyme Nomenclature2.4.1.257
IntEnz2.4.1.257
MEDLINEFind literature relating to 2.4.1.257
MetaCyc2.4.1.257
UniProtKB/Swiss-Prot
Q755C1, ALG2_ASHGO;  Q59LF2, ALG2_CANAL;  Q6FJJ9, ALG2_CANGA;  
Q6BVA4, ALG2_DEBHA;  Q7KWM5, ALG2_DICDI;  Q9H553, ALG2_HUMAN;  
Q6CWQ0, ALG2_KLULA;  Q9DBE8, ALG2_MOUSE;  Q8X0H8, ALG2_NEUCR;  
O94738, ALG2_RHIPU;  Q96WW6, ALG2_SCHPO;  Q6C3V7, ALG2_YARLI;  
P43636, ALG2_YEAST;  

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