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ENZYME entry: EC 2.4.1.257
Accepted Name |
GDP-Man:Man2GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.
|
Alternative Name(s) |
GDP-Man:Man2GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase. |
Reaction catalysed |
alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose <=> alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + GDP + H(+) |
Comment(s) |
- The biosynthesis of asparagine-linked glycoproteins utilizes a
dolichyl diphosphate-linked glycosyl donor, which is assembled by the
series of membrane-bound glycosyltransferases that comprise the
dolichol pathway.
- Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an
alpha1,3-mannosylation (cf. EC 2.4.1.132) of D-Man-beta-(1->4)-D-
GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol, followed by an alpha1,6-
mannosylation, to form the first branched pentasaccharide
intermediate of the dolichol pathway.
|
Cross-references |
BRENDA | 2.4.1.257 |
EC2PDB | 2.4.1.257 |
ExplorEnz | 2.4.1.257 |
PRIAM enzyme-specific profiles | 2.4.1.257 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.257 |
IUBMB Enzyme Nomenclature | 2.4.1.257 |
IntEnz | 2.4.1.257 |
MEDLINE | Find literature relating to 2.4.1.257 |
MetaCyc | 2.4.1.257 |
Rhea expert-curated reactions | 2.4.1.257 |
UniProtKB/Swiss-Prot |
Q755C1, ALG2_ASHGO; | Q59LF2, ALG2_CANAL; | Q6FJJ9, ALG2_CANGA; |
Q6BVA4, ALG2_DEBHA; | Q7KWM5, ALG2_DICDI; | Q9H553, ALG2_HUMAN; |
Q6CWQ0, ALG2_KLULA; | Q9DBE8, ALG2_MOUSE; | Q8X0H8, ALG2_NEUCR; |
O94738, ALG2_RHIPU; | Q96WW6, ALG2_SCHPO; | Q6C3V7, ALG2_YARLI; |
P43636, ALG2_YEAST; |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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