ENZYME entry: EC 2.4.1.257
| Accepted Name |
|---|
| GDP-Man:Man(2)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase.
|
| Alternative Name(s) |
|---|
| GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase. |
| Reaction catalysed |
|---|
| GDP-D-mannose + D-Man-alpha-(1->3)-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> GDP + D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol |
| Comment(s) |
|---|
- The biosynthesis of asparagine-linked glycoproteins utilizes a
dolichyl diphosphate-linked glycosyl donor, which is assembled by the
series of membrane-bound glycosyltransferases that comprise the
dolichol pathway.
- Alg2 mannosyltransferase from Saccharomyces cerevisiae carries out an
alpha-1,3-mannosylation (cf. EC 2.4.1.132) of D-Man-beta-(1->4)-D-
GlcNAc-beta-(1->4)-GlcNAc-diphosphodolichol, followed by an alpha-
1,6-mannosylation, to form the first branched pentasaccharide
intermediate of the dolichol pathway.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.257 |
| EC2PDB | 2.4.1.257 |
| ExplorEnz | 2.4.1.257 |
| PRIAM enzyme-specific profiles | 2.4.1.257 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.257 |
| IUBMB Enzyme Nomenclature | 2.4.1.257 |
| IntEnz | 2.4.1.257 |
| MEDLINE | Find literature relating to 2.4.1.257 |
| MetaCyc | 2.4.1.257 |
| Rhea expert-curated reactions | 2.4.1.257 |
| UniProtKB/Swiss-Prot |
| Q755C1, ALG2_ASHGO; | Q59LF2, ALG2_CANAL; | Q6FJJ9, ALG2_CANGA; |
| Q6BVA4, ALG2_DEBHA; | Q7KWM5, ALG2_DICDI; | Q9H553, ALG2_HUMAN; |
| Q6CWQ0, ALG2_KLULA; | Q9DBE8, ALG2_MOUSE; | Q8X0H8, ALG2_NEUCR; |
| O94738, ALG2_RHIPU; | Q96WW6, ALG2_SCHPO; | Q6C3V7, ALG2_YARLI; |
| P43636, ALG2_YEAST; |
|
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