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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.143

Accepted Name
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
Acetylglucosaminyltransferase II.
Alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.
GlcNAc-T II.
GnTII.
N-acetylglucosaminyltransferase II.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II.
Uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1- 2-N-acetylglucosaminyltransferase.
Uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1- 2-acetylglucosaminyltransferase.
Uridine diphosphoacetylglucosamine-mannoside alpha- 1->6-acetylglucosaminyltransferase.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Comment(s)
  • The enzyme, found in plants and animals, participates in the processing of N-glycans in the Golgi apparatus.
  • Its activity initiates the synthesis of the second antenna of di-antennary complex N-glycans.
  • While the natural substrate (produced by EC 3.2.1.114) is described here, the minimal substrate recognized by the enzyme is alpha-D-Man- (1->6)-(beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->3))-beta-D-Man-R.
  • Formerly EC 2.4.1.51.
Cross-references
BRENDA2.4.1.143
EC2PDB2.4.1.143
ExplorEnz2.4.1.143
PRIAM enzyme-specific profiles2.4.1.143
KEGG Ligand Database for Enzyme Nomenclature2.4.1.143
IUBMB Enzyme Nomenclature2.4.1.143
IntEnz2.4.1.143
MEDLINEFind literature relating to 2.4.1.143
MetaCyc2.4.1.143
UniProtKB/Swiss-Prot
Q9FT88, MGAT2_ARATH;  Q10469, MGAT2_HUMAN;  Q921V5, MGAT2_MOUSE;  
O19071, MGAT2_PIG;  Q09326, MGAT2_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-